1-alkyl-2-acetylglycerophosphocholine esterase

The enzyme 1-alkyl-2-acetylglycerophosphocholine esterase (EC 3.1.1.47) catalyzes the reaction

1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H₂O ${\displaystyle \rightleftharpoons }$ 1-alkyl-sn-glycero-3-phosphocholine + acetate

The former is also known as platelet-activating factor. There are multiple enzymes with this function:

• Lipoprotein-associated phospholipase A2
• Platelet-activating factor acetylhydrolase 2, cytoplasmic
• Platelet-activating factor acetylhydrolase 1b: regulatory subunit 1, catalytic subunit 2, catalytic subunit 3

This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name of this enzyme class is 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine acetohydrolase. Other names in common use include 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine acetylhydrolase, and alkylacetyl-GPC:acetylhydrolase. This enzyme participates in ether lipid metabolism.

As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes 1BWP, 1BWQ, 1BWR, 1ES9, 1FXW, 1VYH, and 1WAB.

• Blank ML, Lee T, Fitzgerald V, Snyder F (1981). "A specific acetylhydrolase for 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (a hypotensive and platelet-activating lipid)". J. Biol. Chem. 256 (1): 175–8. PMID 7451433.
• PAF+acetylhydrolase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• EC 3.1.1.47