AGBL4

Protein-coding gene in the species Homo sapiens

AGBL4
Identifiers
AliasesAGBL4, CCP6, ATP/GTP binding protein-like 4, ATP/GTP binding protein like 4, AGBL carboxypeptidase 4
External IDsOMIM: 616476; MGI: 1918244; HomoloGene: 84880; GeneCards: AGBL4; OMA:AGBL4 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for AGBL4
Genomic location for AGBL4
Band1p33Start48,532,854 bp[1]
End50,023,954 bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for AGBL4
Genomic location for AGBL4
Band4|4 C7- D1Start110,254,858 bp[2]
End111,521,521 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • buccal mucosa cell

  • tendon of biceps brachii

  • testicle

  • gonad

  • prefrontal cortex

  • Brodmann area 23

  • primary visual cortex

  • Brodmann area 9

  • right frontal lobe

  • middle temporal gyrus
Top expressed in
  • spermatid

  • seminiferous tubule

  • choroid plexus of fourth ventricle

  • spermatocyte

  • choroidal fissure

  • primary visual cortex

  • Jacobson's organ

  • superior frontal gyrus

  • lumbar subsegment of spinal cord

  • substantia nigra
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • carboxypeptidase activity
  • tubulin binding
  • zinc ion binding
  • peptidase activity
  • hydrolase activity
  • metallopeptidase activity
  • metal ion binding
  • metallocarboxypeptidase activity
Cellular component
  • cytoplasm
  • ciliary basal body
  • centriole
  • cytosol
  • Golgi apparatus
  • cell projection
  • cytoskeleton
Biological process
  • C-terminal protein deglutamylation
  • protein side chain deglutamylation
  • proteolysis
  • protein deglutamylation
  • defense response to virus
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

84871

78933

Ensembl

ENSG00000186094

ENSMUSG00000061298

UniProt

Q5VU57

Q09LZ8

RefSeq (mRNA)

NM_032785
NM_001323573
NM_001323574
NM_001323575

NM_001048189
NM_001284190
NM_030231

RefSeq (protein)

NP_001310502
NP_001310503
NP_001310504
NP_116174

NP_001041654
NP_001271119
NP_084507

Location (UCSC)Chr 1: 48.53 – 50.02 MbChr 4: 110.25 – 111.52 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

ATP/GTP binding protein like 4 is a protein that in humans is encoded by the AGBL4 gene. [5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000186094 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000061298 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: ATP/GTP binding protein like 4".

Further reading

  • Trynka G, Zhernakova A, Romanos J, Franke L, Hunt KA, Turner G, Bruinenberg M, Heap GA, Platteel M, Ryan AW, de Kovel C, Holmes GK, Howdle PD, Walters JR, Sanders DS, Mulder CJ, Mearin ML, Verbeek WH, Trimble V, Stevens FM, Kelleher D, Barisani D, Bardella MT, McManus R, van Heel DA, Wijmenga C (August 2009). "Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling". Gut. 58 (8): 1078–83. doi:10.1136/gut.2008.169052. PMID 19240061. S2CID 17111427.
  • Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Molecular Medicine. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
  • Wu HY, Rong Y, Correia K, Min J, Morgan JI (January 2015). "Comparison of the enzymatic and functional properties of three cytosolic carboxypeptidase family members". The Journal of Biological Chemistry. 290 (2): 1222–32. doi:10.1074/jbc.M114.604850. PMC 4294487. PMID 25416787.
  • Lin PC, Lin JK, Lin CH, Lin HH, Yang SH, Jiang JK, Chen WS, Chou CC, Tsai SF, Chang SC (December 2015). "Clinical Relevance of Plasma DNA Methylation in Colorectal Cancer Patients Identified by Using a Genome-Wide High-Resolution Array". Annals of Surgical Oncology. 22 (Suppl 3): S1419-27. doi:10.1245/s10434-014-4277-2. PMID 25472652. S2CID 13377596.
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