Protein-coding gene in the species Homo sapiens
AKR7A3 |
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Available structures |
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PDB | Human UniProt search: PDBe RCSB |
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Identifiers |
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Aliases | AKR7A3, AFAR2, aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase), aldo-keto reductase family 7 member A3 |
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External IDs | OMIM: 608477; HomoloGene: 49295; GeneCards: AKR7A3; OMA:AKR7A3 - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 1 (human)[1] |
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| Band | 1p36.13 | Start | 19,282,573 bp[1] |
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End | 19,288,770 bp[1] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - duodenum
- jejunal mucosa
- body of pancreas
- mucosa of transverse colon
- right lobe of liver
- mucosa of ileum
- pancreatic ductal cell
- human kidney
- cardia
- body of stomach
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BioGPS | |
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Gene ontology |
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Molecular function | - electron transfer activity
- oxidoreductase activity
- aldo-keto reductase (NADP) activity
- protein binding
- identical protein binding
- alditol:NADP+ 1-oxidoreductase activity
| Cellular component | - cytoplasm
- extracellular exosome
- cytosol
| Biological process | - xenobiotic metabolic process
- cellular aldehyde metabolic process
- electron transport chain
- aflatoxin metabolic process
- aflatoxin catabolic process
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Location (UCSC) | Chr 1: 19.28 – 19.29 Mb | n/a |
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PubMed search | [2] | n/a |
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Wikidata |
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Aldo-keto reductase family 7 member A3 is a protein that in humans is encoded by the AKR7A3 gene. [3]
Function
Aldo-keto reductases, such as AKR7A3, are involved in the detoxification of aldehydes and ketones.[supplied by OMIM, Apr 2004].
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000162482 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: Aldo-keto reductase family 7 member A3". Retrieved 2018-04-13.
External links
- PDBe-KB provides an overview of all the structure information available in the PDB for Human Aflatoxin B1 aldehyde reductase member 3 (AKR7A3)
Further reading
This article incorporates text from the United States National Library of Medicine, which is in the public domain.