ANAPC10

Protein-coding gene in the species Homo sapiens

ANAPC10
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1JHJ, 4UI9, 5A31, 5G05, 5G04

Identifiers
AliasesANAPC10, APC10, DOC1, anaphase promoting complex subunit 10
External IDsOMIM: 613745; MGI: 1916249; HomoloGene: 32238; GeneCards: ANAPC10; OMA:ANAPC10 - orthologs
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for ANAPC10
Genomic location for ANAPC10
Band4q31.21Start144,831,908 bp[1]
End145,098,541 bp[1]
Gene location (Mouse)
Chromosome 8 (mouse)
Chr.Chromosome 8 (mouse)[2]
Chromosome 8 (mouse)
Genomic location for ANAPC10
Genomic location for ANAPC10
Band8 C1|8 37.79 cMStart80,438,449 bp[2]
End80,505,688 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • oocyte

  • Achilles tendon

  • secondary oocyte

  • gonad

  • ventricular zone

  • ganglionic eminence

  • tibial arteries

  • right testis

  • left testis

  • gastrocnemius muscle
Top expressed in
  • hand

  • medial ganglionic eminence

  • morula

  • blastocyst

  • seminiferous tubule

  • superior cervical ganglion

  • abdominal wall

  • vas deferens

  • atrioventricular valve

  • mandibular prominence
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • ubiquitin protein ligase activity
Cellular component
  • cytoplasm
  • nucleoplasm
  • cytosol
  • anaphase-promoting complex
Biological process
  • cell cycle
  • protein ubiquitination
  • protein K11-linked ubiquitination
  • cell division
  • anaphase-promoting complex-dependent catabolic process
  • positive regulation of ubiquitin protein ligase activity
  • regulation of mitotic cell cycle phase transition
  • ubiquitin-dependent protein catabolic process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10393

68999

Ensembl

ENSG00000164162

ENSMUSG00000036977

UniProt

Q9UM13

Q8K2H6

RefSeq (mRNA)
NM_001256706
NM_001256707
NM_001256708
NM_001256709
NM_001256710

NM_001256711
NM_001256712
NM_014885
NM_001318367

NM_026904
NM_001357234
NM_001357235
NM_001357236
NM_001357237

RefSeq (protein)
NP_001243635
NP_001243636
NP_001243637
NP_001243638
NP_001243639

NP_001243640
NP_001243641
NP_001305296
NP_055700

NP_081180
NP_001344163
NP_001344164
NP_001344165
NP_001344166

Location (UCSC)Chr 4: 144.83 – 145.1 MbChr 8: 80.44 – 80.51 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Anaphase-promoting complex subunit 10 is an enzyme that in humans is encoded by the ANAPC10 gene.[5][6][7]

Interactions

ANAPC10 has been shown to interact with CDC27,[8][9] Mothers against decapentaplegic homolog 3[10] and Mothers against decapentaplegic homolog 2.[10]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000164162 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036977 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Grossberger R, Gieffers C, Zachariae W, Podtelejnikov AV, Schleiffer A, Nasmyth K, Mann M, Peters JM (May 1999). "Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complex". The Journal of Biological Chemistry. 274 (20): 14500–7. doi:10.1074/jbc.274.20.14500. PMID 10318877.
  6. ^ Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (March 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  7. ^ "Entrez Gene: ANAPC10 anaphase promoting complex subunit 10".
  8. ^ Vodermaier HC, Gieffers C, Maurer-Stroh S, Eisenhaber F, Peters JM (September 2003). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Current Biology. 13 (17): 1459–68. Bibcode:2003CBio...13.1459V. doi:10.1016/S0960-9822(03)00581-5. PMID 12956947. S2CID 5942532.
  9. ^ Gmachl M, Gieffers C, Podtelejnikov AV, Mann M, Peters JM (August 2000). "The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex". Proceedings of the National Academy of Sciences of the United States of America. 97 (16): 8973–8. Bibcode:2000PNAS...97.8973G. doi:10.1073/pnas.97.16.8973. PMC 16806. PMID 10922056.
  10. ^ a b Nourry C, Maksumova L, Pang M, Liu X, Wang T (May 2004). "Direct interaction between Smad3, APC10, CDH1 and HEF1 in proteasomal degradation of HEF1". BMC Cell Biology. 5: 20. doi:10.1186/1471-2121-5-20. PMC 420458. PMID 15144564.

Further reading

  • Kurasawa Y, Todokoro K (September 1999). "Identification of human APC10/Doc1 as a subunit of anaphase promoting complex". Oncogene. 18 (37): 5131–7. doi:10.1038/sj.onc.1203133. PMID 10498862. S2CID 20373206.
  • Gotthardt M, Trommsdorff M, Nevitt MF, Shelton J, Richardson JA, Stockinger W, Nimpf J, Herz J (August 2000). "Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction". The Journal of Biological Chemistry. 275 (33): 25616–24. doi:10.1074/jbc.M000955200. PMID 10827173.
  • Gmachl M, Gieffers C, Podtelejnikov AV, Mann M, Peters JM (August 2000). "The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex". Proceedings of the National Academy of Sciences of the United States of America. 97 (16): 8973–8. Bibcode:2000PNAS...97.8973G. doi:10.1073/pnas.97.16.8973. PMC 16806. PMID 10922056.
  • Wendt KS, Vodermaier HC, Jacob U, Gieffers C, Gmachl M, Peters JM, Huber R, Sondermann P (September 2001). "Crystal structure of the APC10/DOC1 subunit of the human anaphase-promoting complex". Nature Structural Biology. 8 (9): 784–8. doi:10.1038/nsb0901-784. PMID 11524682. S2CID 27021761.
  • Vodermaier HC, Gieffers C, Maurer-Stroh S, Eisenhaber F, Peters JM (September 2003). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Current Biology. 13 (17): 1459–68. Bibcode:2003CBio...13.1459V. doi:10.1016/S0960-9822(03)00581-5. PMID 12956947. S2CID 5942532.
  • Nourry C, Maksumova L, Pang M, Liu X, Wang T (May 2004). "Direct interaction between Smad3, APC10, CDH1 and HEF1 in proteasomal degradation of HEF1". BMC Cell Biology. 5: 20. doi:10.1186/1471-2121-5-20. PMC 420458. PMID 15144564.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
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  • 1jhj: Crystal structure of the APC10/Doc1 subunit of the human anaphase-promoting complex
    1jhj: Crystal structure of the APC10/Doc1 subunit of the human anaphase-promoting complex


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