Protein-coding gene in the species Homo sapiens
| ANAPC5 |
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| Available structures |
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| PDB | Ortholog search: PDBe RCSB |
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| List of PDB id codes |
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4UI9, 5A31, 5G05, 5G04 |
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| Identifiers |
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| Aliases | ANAPC5, APC5, anaphase promoting complex subunit 5 |
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| External IDs | OMIM: 606948; MGI: 1929722; HomoloGene: 41118; GeneCards: ANAPC5; OMA:ANAPC5 - orthologs |
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| Gene location (Human) |
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 | | Chr. | Chromosome 12 (human)[1] |
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| | Band | 12q24.31 | Start | 121,308,245 bp[1] |
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| End | 121,399,896 bp[1] |
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| Gene location (Mouse) |
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 | | Chr. | Chromosome 5 (mouse)[2] |
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| | Band | 5|5 F | Start | 122,925,522 bp[2] |
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| End | 122,959,402 bp[2] |
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| RNA expression pattern |
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| Bgee | | Human | Mouse (ortholog) |
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| Top expressed in | - right uterine tube
- body of pancreas
- bronchial epithelial cell
- tibia
- canal of the cervix
- skin of hip
- body of uterus
- corpus callosum
- tibial nerve
- right ovary
|
| | Top expressed in | - fossa
- condyle
- internal carotid artery
- external carotid artery
- fetal liver hematopoietic progenitor cell
- Paneth cell
- superior cervical ganglion
- hair follicle
- trigeminal ganglion
- vas deferens
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| | More reference expression data |
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| BioGPS | 
 | | More reference expression data |
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| Gene ontology |
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| Molecular function | - protein phosphatase binding
- ubiquitin protein ligase activity
| | Cellular component | - nucleoplasm
- cytosol
- nucleus
- anaphase-promoting complex
| | Biological process | - cell cycle
- anaphase-promoting complex-dependent catabolic process
- protein ubiquitination
- protein K11-linked ubiquitination
- cell division
- positive regulation of mitotic metaphase/anaphase transition
- regulation of mitotic cell cycle phase transition
- ubiquitin-dependent protein catabolic process
| | Sources:Amigo / QuickGO |
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| Orthologs |
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| Species | Human | Mouse |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (mRNA) | |
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NM_001137559
NM_016237
NM_001330489 |
| NM_001042491
NM_001289517
NM_001289518
NM_001289519
NM_001289520
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NM_021505 |
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| RefSeq (protein) | |
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NP_001131031
NP_001317418
NP_057321 |
| NP_001035956
NP_001276446
NP_001276447
NP_001276448
NP_001276449
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NP_067480 |
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| Location (UCSC) | Chr 12: 121.31 – 121.4 Mb | Chr 5: 122.93 – 122.96 Mb |
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| PubMed search | [3] | [4] |
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| Wikidata |
| View/Edit Human | View/Edit Mouse |
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Anaphase-promoting complex subunit 5 is an enzyme that in humans is encoded by the ANAPC5 gene.[5][6]
The anaphase-promoting complex (APC) consists of at least 8 protein subunits, including APC5, CDC27 (APC3; MIM 116946), CDC16 (APC6; MIM 603461), and CDC23 (APC8; MIM 603462).[supplied by OMIM][6]
Interactions
ANAPC5 has been shown to interact with ANAPC1,[7][8] ANAPC4,[7] CDC27[7][9][10] and PABPC1.[9]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000089053 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029472 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Yu H, Peters JM, King RW, Page AM, Hieter P, Kirschner MW (March 1998). "Identification of a cullin homology region in a subunit of the anaphase-promoting complex". Science. 279 (5354): 1219–22. Bibcode:1998Sci...279.1219Y. doi:10.1126/science.279.5354.1219. PMID 9469815.
- ^ a b "Entrez Gene: ANAPC5 anaphase promoting complex subunit 5".
- ^ a b c Vodermaier HC, Gieffers C, Maurer-Stroh S, Eisenhaber F, Peters JM (September 2003). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Curr. Biol. 13 (17): 1459–68. Bibcode:2003CBio...13.1459V. doi:10.1016/S0960-9822(03)00581-5. ISSN 0960-9822. PMID 12956947. S2CID 5942532.
- ^ Sumara I, Vorlaufer E, Gieffers C, Peters B H, Peters J M (November 2000). "Characterization of Vertebrate Cohesin Complexes and Their Regulation in Prophase". J. Cell Biol. 151 (4): 749–62. doi:10.1083/jcb.151.4.749. ISSN 0021-9525. PMC 2169443. PMID 11076961.
- ^ a b Koloteva-Levine N, Pinchasi D, Pereman I, Zur A, Brandeis M, Elroy-Stein O (May 2004). "The Apc5 Subunit of the Anaphase-Promoting Complex/Cyclosome Interacts with Poly(A) Binding Protein and Represses Internal Ribosome Entry Site-Mediated Translation". Mol. Cell. Biol. 24 (9): 3577–87. doi:10.1128/MCB.24.9.3577-3587.2004. ISSN 0270-7306. PMC 387753. PMID 15082755.
- ^ Gmachl M, Gieffers C, Podtelejnikov A V, Mann M, Peters J M (August 2000). "The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex". Proc. Natl. Acad. Sci. U.S.A. 97 (16): 8973–8. Bibcode:2000PNAS...97.8973G. doi:10.1073/pnas.97.16.8973. ISSN 0027-8424. PMC 16806. PMID 10922056.
External links
Further reading
- Grossberger R, Gieffers C, Zachariae W, et al. (1999). "Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complex". J. Biol. Chem. 274 (20): 14500–7. doi:10.1074/jbc.274.20.14500. PMID 10318877.
- Gieffers C, Peters BH, Kramer ER, et al. (1999). "Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons". Proc. Natl. Acad. Sci. U.S.A. 96 (20): 11317–22. Bibcode:1999PNAS...9611317G. doi:10.1073/pnas.96.20.11317. PMC 18031. PMID 10500174.
- Gmachl M, Gieffers C, Podtelejnikov AV, et al. (2000). "The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex". Proc. Natl. Acad. Sci. U.S.A. 97 (16): 8973–8. Bibcode:2000PNAS...97.8973G. doi:10.1073/pnas.97.16.8973. PMC 16806. PMID 10922056.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Vodermaier HC, Gieffers C, Maurer-Stroh S, et al. (2004). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Curr. Biol. 13 (17): 1459–68. Bibcode:2003CBio...13.1459V. doi:10.1016/S0960-9822(03)00581-5. PMID 12956947. S2CID 5942532.
- Kraft C, Herzog F, Gieffers C, et al. (2004). "Mitotic regulation of the human anaphase-promoting complex by phosphorylation". EMBO J. 22 (24): 6598–609. doi:10.1093/emboj/cdg627. PMC 291822. PMID 14657031.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Koloteva-Levine N, Pinchasi D, Pereman I, et al. (2004). "The Apc5 Subunit of the Anaphase-Promoting Complex/Cyclosome Interacts with Poly(A) Binding Protein and Represses Internal Ribosome Entry Site-Mediated Translation". Mol. Cell. Biol. 24 (9): 3577–87. doi:10.1128/MCB.24.9.3577-3587.2004. PMC 387753. PMID 15082755.
- Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
- Turnell AS, Stewart GS, Grand RJ, et al. (2005). "The APC/C and CBP/p300 cooperate to regulate transcription and cell-cycle progression". Nature. 438 (7068): 690–5. Bibcode:2005Natur.438..690T. doi:10.1038/nature04151. PMID 16319895. S2CID 4432156.
