ANP32B

Protein-coding gene in the species Homo sapiens
ANP32B
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2ELL, 2RR6

Identifiers
AliasesANP32B, APRIL, PHAPI2, SSP29, acidic nuclear phosphoprotein 32 family member B
External IDsMGI: 1914878; HomoloGene: 21286; GeneCards: ANP32B; OMA:ANP32B - orthologs
Gene location (Human)
Chromosome 9 (human)
Chr.Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for ANP32B
Genomic location for ANP32B
Band9q22.33Start97,983,341 bp[1]
End98,015,943 bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for ANP32B
Genomic location for ANP32B
Band4|4 B1Start46,450,902 bp[2]
End46,472,657 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • tendon of biceps brachii

  • trabecular bone

  • optic nerve

  • thymus

  • internal globus pallidus

  • corpus epididymis

  • cartilage tissue

  • dorsal motor nucleus of vagus nerve

  • parotid gland

  • caput epididymis
Top expressed in
  • tail of embryo

  • genital tubercle

  • zygote

  • primary oocyte

  • secondary oocyte

  • bone marrow

  • epiblast

  • yolk sac

  • ventricular zone

  • thymus
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • histone binding
  • protein binding
  • RNA polymerase binding
Cellular component
  • cytoplasm
  • extracellular exosome
  • nucleolus
  • nucleus
Biological process
  • positive regulation of protein export from nucleus
  • negative regulation of cell differentiation
  • inner ear development
  • nucleosome assembly
  • roof of mouth development
  • vasculature development
  • activation of cysteine-type endopeptidase activity involved in apoptotic process
  • ventricular system development
  • histone exchange
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10541

67628

Ensembl

ENSG00000136938

ENSMUSG00000028333

UniProt

Q92688

Q9EST5

RefSeq (mRNA)

NM_006401

NM_130889

RefSeq (protein)

NP_006392

NP_570959

Location (UCSC)Chr 9: 97.98 – 98.02 MbChr 4: 46.45 – 46.47 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Acidic leucine-rich nuclear phosphoprotein 32 family member B (ANP32B) also known as "acidic protein rich in leucines" (APRIL) is a protein that in humans is encoded by the ANP32B gene.[5][6][7]

APRIL is also the acronym used for an entirely different protein, TNFSF13, a member of the tumor necrosis factor superfamily whose alternative name, A PRoliferation Inducing Ligand, shares the same acronym as that for ANP32B

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000136938 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028333 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Zhu L, Perlaky L, Henning D, Valdez BC (Jan 1998). "Cloning and characterization of a new silver-stainable protein SSP29, a member of the LRR family". Biochem Mol Biol Int. 42 (5): 927–35. doi:10.1080/15216549700203371. PMID 9285060. S2CID 19749385.
  6. ^ Mencinger M, Panagopoulos I, Contreras JA, Mitelman F, Aman P (Mar 1998). "Expression analysis and chromosomal mapping of a novel human gene, APRIL, encoding an acidic protein rich in leucines". Biochim Biophys Acta. 1395 (2): 176–80. doi:10.1016/S0167-4781(97)00165-6. PMID 9473664.
  7. ^ "Entrez Gene: ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B".

Further reading

  • Matilla A, Radrizzani M (2005). "The Anp32 family of proteins containing leucine-rich repeats". Cerebellum. 4 (1): 7–18. doi:10.1080/14734220410019020. PMID 15895553. S2CID 39153579.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Brennan CM, Gallouzi IE, Steitz JA (2000). "Protein ligands to HuR modulate its interaction with target mRNAs in vivo". J. Cell Biol. 151 (1): 1–14. doi:10.1083/jcb.151.1.1. PMC 2189805. PMID 11018049.
  • Gallouzi IE, Steitz JA (2001). "Delineation of mRNA export pathways by the use of cell-permeable peptides". Science. 294 (5548): 1895–901. Bibcode:2001Sci...294.1895G. doi:10.1126/science.1064693. PMID 11729309. S2CID 43726887.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Jiang X, Kim HE, Shu H, et al. (2003). "Distinctive roles of PHAP proteins and prothymosin-alpha in a death regulatory pathway". Science. 299 (5604): 223–6. Bibcode:2003Sci...299..223J. doi:10.1126/science.1076807. PMID 12522243. S2CID 86628810.
  • Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Tao WA, Wollscheid B, O'Brien R, et al. (2005). "Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry". Nat. Methods. 2 (8): 591–8. doi:10.1038/nmeth776. PMID 16094384. S2CID 20475874.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
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