ARPC5

Protein-coding gene in the species Homo sapiens
ARPC5
Identifiers
AliasesARPC5, ARC16, dJ127C7.3, p16-Arc, actin related protein 2/3 complex subunit 5
External IDsOMIM: 604227; MGI: 1915021; HomoloGene: 4176; GeneCards: ARPC5; OMA:ARPC5 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for ARPC5
Genomic location for ARPC5
Band1q25.3Start183,620,846 bp[1]
End183,635,783 bp[1]
Gene location (Mouse)
Chromosome 1 (mouse)
Chr.Chromosome 1 (mouse)[2]
Chromosome 1 (mouse)
Genomic location for ARPC5
Genomic location for ARPC5
Band1|1 G3Start152,642,293 bp[2]
End152,651,348 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • monocyte

  • germinal epithelium

  • lower lobe of lung

  • blood

  • superficial temporal artery

  • appendix

  • trabecular bone

  • granulocyte

  • lymph node

  • placenta
Top expressed in
  • granulocyte

  • ileum

  • spleen

  • thymus

  • stomach

  • ganglionic eminence

  • jejunum

  • neural tube

  • mesencephalon

  • placenta
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • actin filament binding
  • structural constituent of cytoskeleton
  • protein binding
  • actin binding
Cellular component
  • cytoplasm
  • cytosol
  • cell projection
  • focal adhesion
  • arp2/3 protein complex
  • actin cytoskeleton
  • extracellular exosome
  • cytoskeleton
  • neuron projection
  • extracellular region
  • endosome
  • growth cone
  • secretory granule lumen
  • ficolin-1-rich granule lumen
  • lamellipodium
  • nucleus
  • site of double-strand break
Biological process
  • Fc-gamma receptor signaling pathway involved in phagocytosis
  • ephrin receptor signaling pathway
  • regulation of actin filament polymerization
  • Arp2/3 complex-mediated actin nucleation
  • cell migration
  • actin cytoskeleton organization
  • actin filament network formation
  • orbitofrontal cortex development
  • lamellipodium organization
  • smooth muscle cell migration
  • maintenance of cell polarity
  • neutrophil degranulation
  • membrane organization
  • microtubule organizing center localization
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10092

67771

Ensembl

ENSG00000162704

ENSMUSG00000008475

UniProt

O15511

Q9CPW4

RefSeq (mRNA)

NM_005717
NM_001270439

NM_026369

RefSeq (protein)

NP_001257368
NP_005708

NP_080645

Location (UCSC)Chr 1: 183.62 – 183.64 MbChr 1: 152.64 – 152.65 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Actin-related protein 2/3 complex subunit 5 is a protein that in humans is encoded by the ARPC5 gene.[5][6][7]

Function

This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p16 subunit, has yet to be determined.[7]

Interactions

ARPC5 has been shown to interact with ARPC4.[8][9]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000162704 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000008475 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Machesky LM, Reeves E, Wientjes F, Mattheyse FJ, Grogan A, Totty NF, Burlingame AL, Hsuan JJ, Segal AW (1997). "Mammalian actin-related protein 2/3 complex localizes to regions of lamellipodial protrusion and is composed of evolutionarily conserved proteins". Biochem. J. 328 ( Pt 1) (1): 105–12. doi:10.1042/bj3280105. PMC 1218893. PMID 9359840.
  6. ^ Welch MD, DePace AH, Verma S, Iwamatsu A, Mitchison TJ (August 1997). "The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly". J. Cell Biol. 138 (2): 375–84. doi:10.1083/jcb.138.2.375. PMC 2138188. PMID 9230079.
  7. ^ a b "Entrez Gene: ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa".
  8. ^ Millard TH, Behrendt B, Launay S, Fütterer K, Machesky LM (2003). "Identification and characterisation of a novel human isoform of Arp2/3 complex subunit p16-ARC/ARPC5". Cell Motil. Cytoskeleton. 54 (1): 81–90. doi:10.1002/cm.10087. PMID 12451597.
  9. ^ Zhao X, Yang Z, Qian M, Zhu X (2001). "Interactions among subunits of human Arp2/3 complex: p20-Arc as the hub". Biochem. Biophys. Res. Commun. 280 (2): 513–7. doi:10.1006/bbrc.2000.4151. PMID 11162547.

Further reading

  • Welch MD, Iwamatsu A, Mitchison TJ (1997). "Actin polymerization is induced by Arp2/3 protein complex at the surface of Listeria monocytogenes". Nature. 385 (6613): 265–9. Bibcode:1997Natur.385..265W. doi:10.1038/385265a0. PMID 9000076. S2CID 4358529.
  • Robinson RC, Turbedsky K, Kaiser DA, Marchand JB, Higgs HN, Choe S, Pollard TD (2001). "Crystal structure of Arp2/3 complex". Science. 294 (5547): 1679–84. Bibcode:2001Sci...294.1679R. doi:10.1126/science.1066333. PMID 11721045. S2CID 18088124.
  • Gournier H, Goley ED, Niederstrasser H, Trinh T, Welch MD (2001). "Reconstitution of human Arp2/3 complex reveals critical roles of individual subunits in complex structure and activity". Mol. Cell. 8 (5): 1041–52. doi:10.1016/S1097-2765(01)00393-8. PMID 11741539.
  • Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J (2003). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
  • Singh S, Powell DW, Rane MJ, Millard TH, Trent JO, Pierce WM, Klein JB, Machesky LM, McLeish KR (2003). "Identification of the p16-Arc subunit of the Arp 2/3 complex as a substrate of MAPK-activated protein kinase 2 by proteomic analysis". J. Biol. Chem. 278 (38): 36410–7. doi:10.1074/jbc.M306428200. PMID 12829704.
  • Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  • v
  • t
  • e
  • 1k8k: Crystal Structure of Arp2/3 Complex
    1k8k: Crystal Structure of Arp2/3 Complex
  • 1tyq: Crystal structure of Arp2/3 complex with bound ATP and calcium
    1tyq: Crystal structure of Arp2/3 complex with bound ATP and calcium
  • 1u2v: Crystal structure of Arp2/3 complex with bound ADP and calcium
    1u2v: Crystal structure of Arp2/3 complex with bound ADP and calcium
  • 2p9i: Crystal Structure of bovine Arp2/3 Complex co-crystallized with ADP and crosslinked with gluteraldehyde
    2p9i: Crystal Structure of bovine Arp2/3 Complex co-crystallized with ADP and crosslinked with gluteraldehyde
  • 2p9k: Crystal structure of bovine Arp2/3 complex co-crystallized with ATP and crosslinked with glutaraldehyde
    2p9k: Crystal structure of bovine Arp2/3 complex co-crystallized with ATP and crosslinked with glutaraldehyde
  • 2p9l: Crystal Structure of bovine Arp2/3 complex
    2p9l: Crystal Structure of bovine Arp2/3 complex
  • 2p9n: Crystal Structure of bovine Arp2/3 complex co-crystallized with ADP
    2p9n: Crystal Structure of bovine Arp2/3 complex co-crystallized with ADP
  • 2p9p: Crystal Structure of bovine Arp2/3 complex co-crystallized with ADP
    2p9p: Crystal Structure of bovine Arp2/3 complex co-crystallized with ADP
  • 2p9s: Structure of bovine Arp2/3 complex co-crystallized with ATP/Mg2+
    2p9s: Structure of bovine Arp2/3 complex co-crystallized with ATP/Mg2+
  • 2p9u: Crystal structure of bovine Arp2/3 complex co-crystallized with AMP-PNP and calcium
    2p9u: Crystal structure of bovine Arp2/3 complex co-crystallized with AMP-PNP and calcium


Stub icon

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

  • v
  • t
  • e