Acylcarnitine hydrolase

Class of enzymes

acylcarnitine hydrolase

Identifiers

EC no.

3.1.1.28

CAS no.

37278-42-5

Databases

IntEnz

IntEnz view

BRENDA

BRENDA entry

ExPASy

NiceZyme view

KEGG

KEGG entry

MetaCyc

metabolic pathway

PRIAM

profile

PDB structures

RCSB PDB PDBe PDBsum

Gene Ontology

AmiGO / QuickGO

Search
PMC	articles
PubMed	articles
NCBI	proteins

The enzyme acylcarnitine hydrolase (EC 3.1.1.28) catalyzes the reaction

O-acylcarnitine + H₂O

\rightleftharpoons

a fatty acid + L-carnitine

This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name is O-acylcarnitine acylhydrolase. Other names in common use include high activity acylcarnitine hydrolase, HACH, carnitine ester hydrolase, palmitoylcarnitine hydrolase, palmitoyl-L-carnitine hydrolase, long-chain acyl-L-carnitine hydrolase, and palmitoyl carnitine hydrolase.

References

Mahadevan S, Sauer F (1969). "Carnitine ester hydrolase of rat liver". J. Biol. Chem. 244 (16): 4448–53. PMID 5806585.
Mentlein R, Reuter G, Heymann E (1985). "Specificity of two different purified acylcarnitine hydrolases from rat liver, their identity with other carboxylesterases, and their possible function". Arch. Biochem. Biophys. 240 (2): 801–10. doi:10.1016/0003-9861(85)90089-X. PMID 4026306.

Hydrolase: esterases (EC 3.1)

3.1.1: Carboxylic
ester hydrolases

Lipase

Phospholipase
- A1
- A2
- B

3.1.2: Thioesterase

3.1.3: Phosphatase

3.1.4:
Phosphodiesterase

3.1.6: Sulfatase

Nuclease (includes
deoxyribonuclease
and ribonuclease)

3.1.11-16:
Exonuclease

Exodeoxyribonuclease	RecBCD
Exoribonuclease	Oligonucleotidase

3.1.21-31:
Endonuclease

Endodeoxyribonuclease	Deoxyribonuclease I Deoxyribonuclease II Deoxyribonuclease IV Restriction enzyme;see {{Restriction enzyme}} UvrABC endonuclease
Endoribonuclease	RNase III Drosha: Microprocessor complex Dicer: RNA-induced silencing complex RNase H 1 2A 2B 2C RNase P RNase A RNase Z RNase E 1 2 3 4/5 RNase T1
either deoxy- or ribo-	Nuclease S1 Mung bean nuclease Serratia marcescens nuclease Micrococcal nuclease

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)