BAZ2A

Protein-coding gene in humans
BAZ2A
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

4LZ2, 4Q6F, 4QBM, 4QF2, 5AGQ

Identifiers
AliasesBAZ2A, TIP5, WALp3, bromodomain adjacent to zinc finger domain 2A
External IDsOMIM: 605682; MGI: 2151152; HomoloGene: 8393; GeneCards: BAZ2A; OMA:BAZ2A - orthologs
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for BAZ2A
Genomic location for BAZ2A
Band12q13.3Start56,595,596 bp[1]
End56,636,816 bp[1]
Gene location (Mouse)
Chromosome 10 (mouse)
Chr.Chromosome 10 (mouse)[2]
Chromosome 10 (mouse)
Genomic location for BAZ2A
Genomic location for BAZ2A
Band10|10 D3Start127,927,446 bp[2]
End127,965,172 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • sural nerve

  • epithelium of colon

  • beta cell

  • gastric mucosa

  • bone marrow cells

  • right uterine tube

  • left ovary

  • body of uterus

  • right ovary

  • tendon of biceps brachii
Top expressed in
  • zygote

  • female urethra

  • blood

  • hair follicle

  • tibiofemoral joint

  • lymph node

  • mesenteric lymph nodes

  • Gonadal ridge

  • secondary oocyte

  • granulocyte
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
  • DNA binding
  • RNA polymerase I core promoter sequence-specific DNA binding
  • histone binding
  • metal ion binding
  • protein binding
  • nuclear receptor binding
  • lysine-acetylated histone binding
  • RNA binding
Cellular component
  • rDNA heterochromatin
  • chromatin silencing complex
  • nucleolus
  • nucleus
  • cytosol
  • nuclear speck
Biological process
  • chromatin remodeling
  • regulation of transcription, DNA-templated
  • transcription, DNA-templated
  • DNA methylation
  • rDNA heterochromatin assembly
  • histone deacetylation
  • RNA polymerase I preinitiation complex assembly
  • chromatin organization
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

11176

116848

Ensembl

ENSG00000076108

ENSMUSG00000040054

UniProt

Q9UIF9

Q91YE5

RefSeq (mRNA)

NM_001300905
NM_013449
NM_001351156

NM_054078

RefSeq (protein)

NP_001287834
NP_038477
NP_001338085

n/a

Location (UCSC)Chr 12: 56.6 – 56.64 MbChr 10: 127.93 – 127.97 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Bromodomain adjacent to zinc finger domain protein 2A is a protein that in humans is encoded by the BAZ2A gene.[5][6][7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000076108 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040054 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Jones MH, Hamana N, Nezu Ji, Shimane M (Jan 2000). "A novel family of bromodomain genes". Genomics. 63 (1): 40–5. doi:10.1006/geno.1999.6071. PMID 10662543.
  6. ^ Strohner R, Nemeth A, Jansa P, Hofmann-Rohrer U, Santoro R, Längst G, Grummt I (Sep 2001). "NoRC--a novel member of mammalian ISWI-containing chromatin remodeling machines". The EMBO Journal. 20 (17): 4892–900. doi:10.1093/emboj/20.17.4892. PMC 125270. PMID 11532953.
  7. ^ "Entrez Gene: BAZ2A bromodomain adjacent to zinc finger domain, 2A".

Further reading

  • Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Apr 1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 4 (2): 141–50. doi:10.1093/dnares/4.2.141. PMID 9205841.
  • Zhou Y, Santoro R, Grummt I (Sep 2002). "The chromatin remodeling complex NoRC targets HDAC1 to the ribosomal gene promoter and represses RNA polymerase I transcription". The EMBO Journal. 21 (17): 4632–40. doi:10.1093/emboj/cdf460. PMC 126197. PMID 12198165.
  • Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (Aug 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
  • Szafranski K, Schindler S, Taudien S, Hiller M, Huse K, Jahn N, Schreiber S, Backofen R, Platzer M (2007). "Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns". Genome Biology. 8 (8): R154. doi:10.1186/gb-2007-8-8-r154. PMC 2374985. PMID 17672918.


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