Benjamin Cravatt III
Benjamin F. Cravatt III | |
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Born | (1970-04-13) April 13, 1970 (age 54) Houston, Texas, USA |
Education | Stanford University B.S. and B.A. (1992) The Scripps Research Institute Ph.D. (1996) |
Known for | Proteomics |
Scientific career | |
Fields | Chemical Biology |
Institutions | The Scripps Research Institute Vividion Therapeutics ActivX Biosciences Abide Therapeutics |
Doctoral advisors |
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Benjamin Franklin Cravatt III is a professor in the Department of Chemistry at The Scripps Research Institute in La Jolla, California.[1] Considered a co-inventor of activity-based proteomics and a substantial contributor to research on the endocannabinoid system, he is a prominent figure in the nascent field of chemical biology. Cravatt was elected to the National Academy of Sciences in 2014,[1] and the American Academy of Arts and Sciences in 2016.[2] He is Gilula Chair of Chemical Biology, a Cope Scholar, and a Searle Scholar.
Early life and education
His father was a dentist and his mother a dental hygienist, both of whom instilled in Cravatt an interest in biology as a child.[1]
Cravatt entered Stanford University in 1988, graduating in 1992 with a BS in the Biological Sciences and a BA in History.[1][3] He then received a PhD in Macromolecular and Cellular Structure and Chemistry from The Scripps Research Institute in 1996,[1] where he worked under the joint supervision of Dale L. Boger and Richard Lerner.
Research
His early contributions to the cannabinoid field include identification and characterization of the endocannabinoid-terminating enzyme fatty acid amide hydrolase (FAAH),[1] as well as the isolation of the novel soporific compound oleamide from cerebrospinal fluid.[4][5]
Cravatt and colleagues pioneered the activity-based protein profiling (ABPP) chemical proteomic technology, which they used in 2010 to elucidate certain global proteomic features of cysteine proteases.[1] Cravatt's lab has since combined the ABPP technology with metabolomics.[1]
Awards and professional service
Among the awards that Cravatt has received are the TR100 Award in 2002, the Eli Lilly Award in Biological Chemistry in 2004, the ASBMB-Merck Award in 2014 and the Sato Memorial Award in 2015.[1] Cravatt also received an NCI MERIT grant in 2009.[1] In 2022 he was awarded the Wolf Prize in Chemistry.[6]
Cravatt is a co-founder of Vividion Therapeutics, Abide Therapeutics and ActivX Biosciences. He formerly served as an Associate Editor for the Journal of the American Chemical Society and Chemical Science.
See also
References
- ^ a b c d e f g h i j Viegas, Jennifer (2 February 2016). "Profile of Benjamin Cravatt". Proceedings of the National Academy of Sciences of the United States of America. 113 (5): 1109–11. Bibcode:2016PNAS..113.1109V. doi:10.1073/pnas.1525099113. PMC 4747733. PMID 26811454.
- ^ "National Academy of Sciences Members and Foreign Associates Elected" (Press release). United States: National Academy of Sciences. 29 April 2014. Archived from the original on 18 August 2015. Retrieved 2016-12-31.
Cravatt, Benjamin F.; professor and chair, department of chemical physiology, The Scripps Research Institute, La Jolla, Calif.
- ^ Bogyo, Matthew; Cravatt, Benjamin F. (February 2007). "Genomics and proteomics: From genes to function: advances in applications of chemical and systems biology". Current Opinion in Chemical Biology (Editorial Overview). 11: 1–3. doi:10.1016/j.cbpa.2006.12.029.
- ^ Cravatt, B.F.; Giang, D.K.; Mayfield, S.P.; Boger, D.L.; Lerner, R.A. (7 November 1996). "Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides". Nature. 384 (6604): 83–7. Bibcode:1996Natur.384...83C. doi:10.1038/384083a0. PMID 8900284. S2CID 4288981.
- ^ Cravatt, BF; Prospero-Garcia, O; Siuzdak, G; Gilula, NB; Henriksen, SJ; Boger, DL; Lerner, RA (9 June 1995). "Chemical characterization of a family of brain lipids that induce sleep". Science. 268 (5216): 1506–9. Bibcode:1995Sci...268.1506C. doi:10.1126/science.7770779. PMID 7770779.
- ^ Wolf Prize in Chemistry 2022
External links
- The Scripps Research Institute
- The Cravatt Lab at TSRI
- Vividion Therapeutics
- Abide Therapeutics
- ActivX Biosciences
- TR35 Young Innovator 2002
- Interview with Ben Cravatt on the website of the Royal Society of Chemistry.
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- William M. Allen (1935)
- Harold S. Alcott (1937)
- Abraham White (1938)
- George Wald (1939)
- Eric G. Ball (1940)
- David Rittenberg (1941)
- Earl A. Evans, Jr. (1942)
- Herbert E. Carter (1943)
- Joseph S. Fruton (1944)
- Max A. Lauffer (1945)
- John D. Ferry (1946)
- Sidney Colowick (1947)
- Dilworth Woodley (1948)
- Irving M. Klotz (1949)
- William Shive (1950)
- John M. Buchanan (1951)
- David M. Bonner (1952)
- Nathan O. Kaplan (1953)
- Harvey Itano (1954)
- William F. Neuman (1955)
- Robert A. Alberty (1956)
- Harold A. Scheraga (1957)
- Lester J. Reed (1958)
- Paul Berg (1959)
- James Watson (1960)
- Frederick Crane (1961)
- Jerard Hurwitz (1962)
- William P. Jencks (1963)
- Bruce Ames (1964)
- Gerald M. Edelman (1965)
- Phillips W. Robbins (1966)
- Gordon G. Hammes (1967)
- Charles C. Richardson (1968)
- Mario R. Capecchi (1969)
- Lubert Stryer (1970)
- David F. Wilson (1971)
- Bruce M. Alberts (1972)
- C. Fred Fox (1973)
- James E. Dahlberg (1974)
- Mark Ptashne (1975)
- Joan A. Steitz (1976)
- Robert G. Roeder (1977)
- Charles R. Cantor (1978)
- Christopher T. Walsh (1979)
- Phillip A. Sharp (1980)
- Roger D. Kornberg (1981)
- Harold M. Weintraub (1982)
- Richard Axel (1983)
- David V. Goeddel (1984)
- Gerald M. Rubin (1985)
- James E. Rothman (1986)
- Jacqueline K. Barton (1987)
- Peter Walter (1988)
- Michael M. Cox (1989)
- George L. McLendon (1990)
- Peter G. Schultz (1991)
- William DeGrado (1992)
- Stuart L. Schreiber (1993)
- Peter S. Kim (1994)
- Jeremy M. Berg (1995)
- Gregory L. Verdine (1996)
- Alanna Schepartz (1997)
- John Kuriyan (1998)
- Chaitan Khosla (1999)
- Xiaodong Wang (2000)
- Jennifer Doudna (2001)
- Kevan M. Shokat (2002)
- Andreas Matouschek (2003)
- Benjamin Cravatt III (2004)
- Dewey G. McCafferty (2005)
- Linda Hsieh-Wilson (2006)
- Anna K. Mapp (2007)
- Paul J. Hergenrother (2008)
- Scott K. Silverman (2009)
- Alice Y. Ting (2010)
- Nathanael Gray (2011)
- Christopher J. Chang (2012)
- Matthew D. Disney (2013)
- Yi Tang (2014)
- Minkui Luo (2015)
- Elizabeth Nolan (2016)
- Howard Hang (2017)
- Bradley Pentelute (2018)
- Neal K. Devaraj (2019)
- Yimon Aye (2020)
- Jordan L. Meier (2021)