CTDSP1
Protein-coding gene in the species Homo sapiens
CTDSP1 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | CTDSP1, NIF3, NLI-IF, NLIIF, SCP1, CTD small phosphatase 1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 605323; MGI: 2654470; HomoloGene: 100834; GeneCards: CTDSP1; OMA:CTDSP1 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 is an enzyme that in humans is encoded by the CTDSP1 gene.[5][6][7]
Interactions
CTDSP1 has been shown to interact with SNAI1.[8]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000144579 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026176 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Ma X, Wright J, Dou S, Olsen P, Teeter L, Adams G, Graviss E (Apr 2002). "Ethnic divergence and linkage disequilibrium of novel SNPs in the human NLI-IF gene: evidence of human origin and lack of association with tuberculosis susceptibility". Journal of Human Genetics. 47 (3): 140–5. doi:10.1007/s100380200016. PMID 11950066.
- ^ Yeo M, Lin PS, Dahmus ME, Gill GN (July 2003). "A novel RNA polymerase II C-terminal domain phosphatase that preferentially dephosphorylates serine 5". The Journal of Biological Chemistry. 278 (28): 26078–85. doi:10.1074/jbc.M301791200. PMID 12721286.
- ^ "Entrez Gene: CTDSP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1".
- ^ Wu Y, Evers BM, Zhou BP (January 2009). "Small C-terminal domain phosphatase enhances snail activity through dephosphorylation". The Journal of Biological Chemistry. 284 (1): 640–8. doi:10.1074/jbc.M806916200. PMC 2610500. PMID 19004823.
Further reading
- Marquet S, Lepage P, Hudson TJ, Musser JM, Schurr E (September 2000). "Complete nucleotide sequence and genomic structure of the human NRAMP1 gene region on chromosome region 2q35". Mammalian Genome. 11 (9): 755–62. doi:10.1007/s003350010151. PMID 10967134. S2CID 11308779.
- Fernandes AO, Campagnoni CW, Kampf K, Feng JM, Handley VW, Schonmann V, et al. (February 2004). "Identification of a protein that interacts with the golli-myelin basic protein and with nuclear LIM interactor in the nervous system". Journal of Neuroscience Research. 75 (4): 461–71. doi:10.1002/jnr.10882. PMID 14743429. S2CID 29467544.
- Yeo M, Lee SK, Lee B, Ruiz EC, Pfaff SL, Gill GN (January 2005). "Small CTD phosphatases function in silencing neuronal gene expression". Science. 307 (5709): 596–600. Bibcode:2005Sci...307..596Y. doi:10.1126/science.1100801. PMID 15681389. S2CID 39722809.
- Sapkota G, Knockaert M, Alarcón C, Montalvo E, Brivanlou AH, Massagué J (December 2006). "Dephosphorylation of the linker regions of Smad1 and Smad2/3 by small C-terminal domain phosphatases has distinct outcomes for bone morphogenetic protein and transforming growth factor-beta pathways". The Journal of Biological Chemistry. 281 (52): 40412–9. doi:10.1074/jbc.M610172200. PMID 17085434.
External links
- Human CTDSP1 genome location and CTDSP1 gene details page in the UCSC Genome Browser.
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PDB gallery
- 1t9z: Three-dimensional structure of a RNA-polymerase II binding protein.
- 1ta0: Three-dimensional structure of a RNA-polymerase II binding protein with associated ligand.
- 2ghq: CTD-specific phosphatase Scp1 in complex with peptide C-terminal domain of RNA polymerase II
- 2ght: CTD-specific phosphatase Scp1 in complex with peptide from C-terminal domain of RNA polymerase II
This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it. |
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