CTDSP1

Protein-coding gene in the species Homo sapiens
CTDSP1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1T9Z, 1TA0, 2GHQ, 2GHT, 3L0B, 3L0C, 3L0Y, 3PGL, 4YGY, 4YH1

Identifiers
AliasesCTDSP1, NIF3, NLI-IF, NLIIF, SCP1, CTD small phosphatase 1
External IDsOMIM: 605323; MGI: 2654470; HomoloGene: 100834; GeneCards: CTDSP1; OMA:CTDSP1 - orthologs
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for CTDSP1
Genomic location for CTDSP1
Band2q35Start218,398,256 bp[1]
End218,405,941 bp[1]
Gene location (Mouse)
Chromosome 1 (mouse)
Chr.Chromosome 1 (mouse)[2]
Chromosome 1 (mouse)
Genomic location for CTDSP1
Genomic location for CTDSP1
Band1|1 C3Start74,430,668 bp[2]
End74,436,444 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • granulocyte

  • right coronary artery

  • gastric mucosa

  • body of stomach

  • Descending thoracic aorta

  • apex of heart

  • left uterine tube

  • right ovary

  • canal of the cervix

  • popliteal artery
Top expressed in
  • granulocyte

  • urinary bladder

  • adrenal gland

  • white adipose tissue

  • muscle tissue

  • muscle of thigh

  • human kidney

  • lip

  • skeletal muscle tissue

  • esophagus
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • phosphatase activity
  • RNA polymerase II CTD heptapeptide repeat phosphatase activity
  • protein binding
  • phosphoprotein phosphatase activity
  • hydrolase activity
  • metal ion binding
Cellular component
  • extracellular exosome
  • nucleus
  • nucleoplasm
Biological process
  • regulation of transcription by RNA polymerase II
  • negative regulation of G1/S transition of mitotic cell cycle
  • negative regulation of protein phosphorylation
  • negative regulation of neurogenesis
  • protein dephosphorylation
  • negative regulation of neuron differentiation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

58190

227292

Ensembl

ENSG00000144579

ENSMUSG00000026176

UniProt

Q9GZU7

P58466

RefSeq (mRNA)

NM_001206878
NM_001206879
NM_021198
NM_182642

NM_153088

RefSeq (protein)

NP_001193807
NP_067021
NP_872580

NP_694728

Location (UCSC)Chr 2: 218.4 – 218.41 MbChr 1: 74.43 – 74.44 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 is an enzyme that in humans is encoded by the CTDSP1 gene.[5][6][7]

Interactions

CTDSP1 has been shown to interact with SNAI1.[8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000144579 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026176 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ma X, Wright J, Dou S, Olsen P, Teeter L, Adams G, Graviss E (Apr 2002). "Ethnic divergence and linkage disequilibrium of novel SNPs in the human NLI-IF gene: evidence of human origin and lack of association with tuberculosis susceptibility". Journal of Human Genetics. 47 (3): 140–5. doi:10.1007/s100380200016. PMID 11950066.
  6. ^ Yeo M, Lin PS, Dahmus ME, Gill GN (July 2003). "A novel RNA polymerase II C-terminal domain phosphatase that preferentially dephosphorylates serine 5". The Journal of Biological Chemistry. 278 (28): 26078–85. doi:10.1074/jbc.M301791200. PMID 12721286.
  7. ^ "Entrez Gene: CTDSP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1".
  8. ^ Wu Y, Evers BM, Zhou BP (January 2009). "Small C-terminal domain phosphatase enhances snail activity through dephosphorylation". The Journal of Biological Chemistry. 284 (1): 640–8. doi:10.1074/jbc.M806916200. PMC 2610500. PMID 19004823.

Further reading

  • Marquet S, Lepage P, Hudson TJ, Musser JM, Schurr E (September 2000). "Complete nucleotide sequence and genomic structure of the human NRAMP1 gene region on chromosome region 2q35". Mammalian Genome. 11 (9): 755–62. doi:10.1007/s003350010151. PMID 10967134. S2CID 11308779.
  • Fernandes AO, Campagnoni CW, Kampf K, Feng JM, Handley VW, Schonmann V, et al. (February 2004). "Identification of a protein that interacts with the golli-myelin basic protein and with nuclear LIM interactor in the nervous system". Journal of Neuroscience Research. 75 (4): 461–71. doi:10.1002/jnr.10882. PMID 14743429. S2CID 29467544.
  • Yeo M, Lee SK, Lee B, Ruiz EC, Pfaff SL, Gill GN (January 2005). "Small CTD phosphatases function in silencing neuronal gene expression". Science. 307 (5709): 596–600. Bibcode:2005Sci...307..596Y. doi:10.1126/science.1100801. PMID 15681389. S2CID 39722809.
  • Sapkota G, Knockaert M, Alarcón C, Montalvo E, Brivanlou AH, Massagué J (December 2006). "Dephosphorylation of the linker regions of Smad1 and Smad2/3 by small C-terminal domain phosphatases has distinct outcomes for bone morphogenetic protein and transforming growth factor-beta pathways". The Journal of Biological Chemistry. 281 (52): 40412–9. doi:10.1074/jbc.M610172200. PMID 17085434.
  • v
  • t
  • e
  • 1t9z: Three-dimensional structure of a RNA-polymerase II binding protein.
    1t9z: Three-dimensional structure of a RNA-polymerase II binding protein.
  • 1ta0: Three-dimensional structure of a RNA-polymerase II binding protein with associated ligand.
    1ta0: Three-dimensional structure of a RNA-polymerase II binding protein with associated ligand.
  • 2ghq: CTD-specific phosphatase Scp1 in complex with peptide C-terminal domain of RNA polymerase II
    2ghq: CTD-specific phosphatase Scp1 in complex with peptide C-terminal domain of RNA polymerase II
  • 2ght: CTD-specific phosphatase Scp1 in complex with peptide from C-terminal domain of RNA polymerase II
    2ght: CTD-specific phosphatase Scp1 in complex with peptide from C-terminal domain of RNA polymerase II
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