Carboxylesterase 2

Enzyme hydrolysing long-chain fatty esters

CES2

Identifiers

Aliases

CES2, CE-2, CES2A1, PCE-2, iCE, Carboxylesterase 2, CES-2

External IDs

OMIM: 605278; MGI: 3648740; HomoloGene: 128645; GeneCards: CES2; OMA:CES2 - orthologs

Gene location (Human)

Chr.	Chromosome 16 (human)^[1]

Band	16q22.1	Start	66,934,444 bp^[1]
Band	16q22.1	End	66,945,096 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 8 (mouse)^[2]

Band	8\|8 D3	Start	105,727,485 bp^[2]
Band	8\|8 D3	End	105,747,810 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

jejunal mucosa

mucosa of ileum

mucosa of colon

mucosa of sigmoid colon

duodenum

mucosa of transverse colon

mucosa of pharynx

rectum

right lobe of liver

kidney tubule

Top expressed in

proximal tubule

human kidney

right kidney

duodenum

jejunum

liver

colon

testicle

islet of Langerhans

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	methylumbelliferyl-acetate deacetylase activity hydrolase activity carboxylic ester hydrolase activity methyl indole-3-acetate esterase activity
Cellular component	endoplasmic reticulum lumen endoplasmic reticulum extracellular space
Biological process	xenobiotic metabolic process catabolic process prostaglandin metabolic process
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


8824


436059

Ensembl


ENSG00000172831


ENSMUSG00000091813

UniProt


O00748


F6Z9B9

RefSeq (mRNA)

NM_003869 NM_198061 NM_001365405 NM_001365406 NM_001365407
NM_001365408


NM_001272045

RefSeq (protein)

NP_003860 NP_932327 NP_001352334 NP_001352335 NP_001352336
NP_001352337


NP_001258974

Location (UCSC)

Chr 16: 66.93 – 66.95 Mb

Chr 8: 105.73 – 105.75 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Carboxylesterase 2 is an enzyme that in humans is encoded by the CES2 gene.^[5]^[6]^[7] It is a member of the alpha/beta fold hydrolase family.^[8]

Carboxylesterase 2 is a member of a large multigene family. The enzymes encoded by these genes are responsible for the hydrolysis of ester- and amide-bond-containing drugs such as cocaine and heroin. They also hydrolyze long-chain fatty acid esters and thioesters. The specific function of this enzyme has not yet been determined; however, it is speculated that carboxylesterases may play a role in lipid metabolism and/or the blood–brain barrier system. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.^[7]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.^{[§ 1]}

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|alt=Fluorouracil (5-FU) Activity edit]]

Fluorouracil (5-FU) Activity edit

^ The interactive pathway map can be edited at WikiPathways: "FluoropyrimidineActivity_WP1601".

Click on genes, proteins and metabolites below to link to respective articles. ^{[§ 1]}

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|alt=Irinotecan Pathway edit]]

Irinotecan Pathway edit

^ The interactive pathway map can be edited at WikiPathways: "IrinotecanPathway_WP229".

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000172831 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000091813 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Pindel EV, Kedishvili NY, Abraham TL, Brzezinski MR, Zhang J, Dean RA, Bosron WF (June 1997). "Purification and cloning of a broad substrate specificity human liver carboxylesterase that catalyzes the hydrolysis of cocaine and heroin". The Journal of Biological Chemistry. 272 (23): 14769–14775. doi:10.1074/jbc.272.23.14769. PMID 9169443.
^ Schwer H, Langmann T, Daig R, Becker A, Aslanidis C, Schmitz G (April 1997). "Molecular cloning and characterization of a novel putative carboxylesterase, present in human intestine and liver". Biochemical and Biophysical Research Communications. 233 (1): 117–120. doi:10.1006/bbrc.1997.6413. PMID 9144407.
^ ^a ^b "Entrez Gene: CES2 carboxylesterase 2 (intestine, liver)".
^ Imai T (June 2006). "Human carboxylesterase isozymes: catalytic properties and rational drug design". Drug Metabolism and Pharmacokinetics. 21 (3): 173–185. doi:10.2133/dmpk.21.173. PMID 16858120.