Cipemastat

Cipemastat
Names
Preferred IUPAC name
(2R,3R)-3-(Cyclopentylmethyl)-N-hydroxy-4-oxo-4-(piperidin-1-yl)-2-[(3,4,4-trimethyl-2,5-dioxoimidazolidin-1-yl)methyl]butanamide
Identifiers
CAS Number
  • 190648-49-8 ☒N
3D model (JSmol)
  • Interactive image
ChEMBL
  • ChEMBL115653 checkY
ChemSpider
  • 8000097 checkY
IUPHAR/BPS
  • 6466
PubChem CID
  • 9824350
UNII
  • 02HQ4TYQ60 checkY
CompTox Dashboard (EPA)
  • DTXSID10897569 Edit this at Wikidata
InChI
  • InChI=1S/C22H36N4O5/c1-22(2)20(29)26(21(30)24(22)3)14-17(18(27)23-31)16(13-15-9-5-6-10-15)19(28)25-11-7-4-8-12-25/h15-17,31H,4-14H2,1-3H3,(H,23,27)/t16-,17+/m1/s1 checkY
    Key: GFUITADOEPNRML-SJORKVTESA-N checkY
  • CC1(C)NC(=O)N(C[C@@H]([C@@H](CC2CCCC2)C(=O)N3CCCCC3)C(=O)NO)C1=O
Properties
Chemical formula
 C22H36N4O5
Molar mass 436.553 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references
Chemical compound

Cipemastat (rINN, also known as Ro 32-3555 and by the tentative trade name Trocade) is a selective inhibitor of matrix metalloproteinase-1 that has been investigated as an anti-arthritis agent.[1] It is being developed by Roche.

References

  1. ^ Hemmings F, Farhan M, Rowland J, Banken L, Jain R (2001). "Tolerability and pharmacokinetics of the collagenase-selective inhibitor Trocade in patients with rheumatoid arthritis". Rheumatology (Oxford). 40 (5): 537–43. doi:10.1093/rheumatology/40.5.537. PMID 11371662.
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