Collagen-induced arthritis

Medical condition

Collagen-induced arthritis

Collagen-induced arthritis (CIA) is a condition induced in mice (or rats) to study rheumatoid arthritis.^[1]

CIA is induced in mice by injecting them with an emulsion of complete Freund's adjuvant and type II collagen.^[2]

In rats, only one injection is needed, but mice are normally injected twice.^[3]

References

^ Williams, RO (2004). "Collagen-induced arthritis as a model for rheumatoid arthritis". Tumor Necrosis Factor. Vol. 98. pp. 207–16. doi:10.1385/1-59259-771-8:207. ISBN 978-1-59259-771-0. PMID 15064442. {{cite book}}: |journal= ignored (help)
^ Brand, DD; Latham, KA; Rosloniec, EF (2007). "Collagen-induced arthritis". Nat Protoc. 2 (5): 1269–75. doi:10.1038/nprot.2007.173. PMID 17546023.
^ Arthritis in mice induced by a single immunisation with collagen

Inglis, Julia J.; Criado, Gabriel; Medghalchi, Mino; Andrews, Melanie; Sandison, Ann; Feldmann, Marc; Williams, Richard O. (29 October 2007). "Collagen-induced arthritis in C57BL/6 mice is associated with a robust and sustained T-cell response to type II collagen". Arthritis Research & Therapy. 9 (5): R113. doi:10.1186/ar2319. ISSN 1478-6354. PMC 2212575. PMID 17967186.
Pietrosimone, K. M.; Jin, M.; Poston, B.; Liu, P. (20 October 2015). "Collagen-Induced Arthritis: A model for Murine Autoimmune Arthritis". Bio-Protocol. 5 (20): e1626. doi:10.21769/bioprotoc.1626. ISSN 2331-8325. PMC 4629450. PMID 26539560.
Holmdahl, Rikard; Bockermann, Robert; Bäcklund, Johan; Yamada, Hisakata (1 February 2002). "The molecular pathogenesis of collagen-induced arthritis in mice—a model for rheumatoid arthritis". Ageing Research Reviews. 1 (1): 135–147. doi:10.1016/S0047-6374(01)00371-2. ISSN 1568-1637. S2CID 28243127.