Desocodeine
Names | |
---|---|
IUPAC name 3-Methoxy-17-methyl-4,5α-epoxymorphinan | |
Systematic IUPAC name (4R,4aR,7aS,12bS)-9-Methoxy-3-methyl-2,3,4,4a,5,6,7,7a-octahydro-1H-4,12-methano[1]benzofuro[3,2-e]isoquinoline | |
Other names Dihydrodeoxycodeine | |
Identifiers | |
CAS Number |
|
3D model (JSmol) |
|
ChemSpider |
|
PubChem CID |
|
UNII |
|
CompTox Dashboard (EPA) |
|
InChI
| |
| |
Properties | |
Chemical formula | C18H23NO2 |
Molar mass | 285.387 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references |
Desocodeine is a potent semi-synthetic opioid which is the penultimate intermediate in the manufacture of desomorphine from codeine.[1][2] Desocodeine is a potent analgesic, being as potent as morphine.It is partially metabolized into desomorphine, among others, after parenteral and oral administration.[3][4]
Since 1936, desocodeine has been classified in the US as a Schedule I controlled substance under the Controlled Substances Act, indicating that the FDA has determined that there are no legal medicinal uses for it.[5]
In Canada, desocodeine is classified as a Schedule I drug under the Controlled Drugs and Substances Act.
References
- ^ PubChem. "Desocodeine". pubchem.ncbi.nlm.nih.gov. Retrieved 2022-11-15.
- ^ "Desocodeine | C18H23NO2 | ChemSpider". www.chemspider.com. Retrieved 2022-11-15.
- ^ Eddy NB (1 November 1935). "STUDIES OF MORPHINE, CODEINE AND THEIR DERIVATIVES X. DESOXYMORPHINE-C, DESOXYCODEINE-C AND THEIR HYDROGENATED DERIVATIVES". Journal of Pharmacology and Experimental Therapeutics. 55 (1): 257–267. S2CID 93217792.
- ^ Himmelsbach Clifton K (1939). "STUDIES OF CERTAIN ADDICTION CHARACTERISTICS OF (a) DIHYDROMORPHINE ("PARAMORPHAN"), (b) DIHYDRODESOXYMORPHINE-D ("DESOMORPHINE"), (c) DIHYDRODESOXYCODEINE-D ("DESOCODEINE"), AND (d) METHYLDIHYDROMORPHINONE ("METOPON")". Journal of Pharmacology and Experimental Therapeutics. 67: 239–249. S2CID 102042333.
{{cite journal}}
: CS1 maint: date and year (link) - ^ "DEA Diversion Control Division". Archived from the original on 4 March 2016. Retrieved 4 May 2015.
- v
- t
- e
(MOR)
(DOR)
(KOR)
(NOP)
Agonists |
|
---|---|
Antagonists |
|
- Enkephalinase inhibitors: Amastatin
- BL-2401
- Candoxatril
- D -Phenylalanine
- Dexecadotril (retorphan)
- Ecadotril (sinorphan)
- Kelatorphan
- Racecadotril (acetorphan)
- RB-101
- RB-120
- RB-3007
- Opiorphan
- Selank
- Semax
- Spinorphin
- Thiorphan
- Tynorphin
- Ubenimex (bestatin)
- Propeptides: β-Lipotropin (proendorphin)
- Prodynorphin
- Proenkephalin
- Pronociceptin
- Proopiomelanocortin (POMC)
- Others: Kyotorphin (met-enkephalin releaser/degradation stabilizer)
This analgesic-related article is a stub. You can help Wikipedia by expanding it. |
- v
- t
- e