Dibutyl squarate
Names | |
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IUPAC name 3,4-Dibutoxy-3-cyclobutene-1,2-dione | |
Other names Squaric acid dibutyl ester; SADBE | |
Identifiers | |
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3D model (JSmol) |
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Beilstein Reference | 1968189 |
ChEBI |
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DrugBank |
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ECHA InfoCard | 100.157.137 |
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CompTox Dashboard (EPA) |
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InChI
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Properties | |
Chemical formula | C12H18O4 |
Molar mass | 226.272 g·mol−1 |
Hazards | |
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Warning | |
Hazard statements | H315, H317, H319, H335 |
Precautionary statements | P261, P264, P264+P265, P271, P272, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P333+P313, P337+P317, P362+P364, P403+P233, P405, P501 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references |
Chemical compound
Dibutyl squarate (also known as squaric acid dibutyl ester or SADBE) is a chemical compound with the molecular formula C12H18O4. It is the dibutyl derivative of squaric acid.
Medically, it is used for the treatment of warts[1] and for treating alopecia areata or alopecia totalis (autoimmune hair loss) through topical immunotherapy involving the production of an allergic rash.[2][3] Dibutyl squarate is currently undergoing trials for use in treating herpes labialis (cold sores).[4]
References
- ^ Silverberg, Nanette B.; Lim, Joseph K.; Paller, Amy S.; Mancini, Anthony J. (2000). "Squaric acid immunotherapy for warts in children". Journal of the American Academy of Dermatology. 42 (5): 803–808. doi:10.1067/mjd.2000.103631. PMID 10775858.
- ^ Yoshimasu, Takashi; Furukawa, Fukumi (2016). "Modified immunotherapy for alopecia areata". Autoimmunity Reviews. 15 (7): 664–667. doi:10.1016/j.autrev.2016.02.021. PMID 26932732.
- ^ Holzer, A. M.; Kaplan, L. L.; Levis, W. R. (2006). "Haptens as drugs: contact allergens are powerful topical immunomodulators". J. Drugs Dermatol. 5 (5): 410–416. PMID 16703776.
- ^ Kimball, Alexandra (2017-05-05). "A Clinical Trial to Test the Safety and Efficacy of Squaric Acid Dibutyl Ester for the Treatment of Herpes Labialis". Massachusetts General Hospital.
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