Dornase alfa
Pharmaceutical drug
- US DailyMed: Dornase alfa
category
- AU: B1[1]
administration
- R05CB13 (WHO)
- AU: S4 (Prescription only)[1]
- CA: ℞-only / Schedule D[2]
- US: ℞-only[3]
- In general: ℞ (Prescription only)
- 143831-71-4
N
- DB00003
Y
- none
- 953A26OA1Y
- D03896
- DTXSID801010888
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Dornase alfa, sold under the brand name Pulmozyme, is used for the treatment of cystic fibrosis.[3] It is a recombinant human deoxyribonuclease I (rhDNase), an enzyme which selectively cleaves DNA.[3] Dornase alfa hydrolyzes the DNA present in sputum/mucus and reduces viscosity in the lungs, promoting improved clearance of secretions.[3] It is produced in Chinese hamster ovary cells.[3]
Medical uses
Dornase alfa is indicated for the management of people with cystic fibrosis to improve pulmonary function.[3]
Society and culture
Legal status
Dornase alfa is an orphan drug.[4]
Research
Dornase alfa has been shown to improve lung function in non-cystic fibrosis pre-term infants atelectasis.[5][6]
References
- ^ a b Product guildlink.com.au
- ^ "Pulmozyme Product information". Health Canada. 25 April 2012. Retrieved 9 January 2023.
- ^ a b c d e f "Pulmozyme- dornase alfa solution". DailyMed. 21 October 2020. Retrieved 9 January 2023.
- ^ Collier, Joe (1 September 1995). "Dornase-alfa and orphan drugs". The Lancet. 346 (8975): 633. doi:10.1016/S0140-6736(95)91460-9. PMID 7651014. S2CID 5456247.
- ^ Erdeve O, Uras N, Atasay B, Arsan S (2007). "Efficacy and safety of nebulized recombinant human DNase as rescue treatment for persistent atelectasis in newborns: case-series". Croat Med J. 48 (2): 234–9. PMC 2080511. PMID 17436388.
- ^ Hendriks T, de Hoog M, Lequin MH, Devos AS, Merkus PJ (2005). "DNase and atelectasis in non-cystic fibrosis pediatric patients". Crit Care. 9 (4): R351-6. doi:10.1186/cc3544. PMC 1269442. PMID 16137347.
- v
- t
- e
- Acetylcysteine#
- Ambroxol
- Bromhexine
- Carbocisteine
- Dembrexine hydrochloride
- Domiodol
- Dornase alfa
- Eprazinone
- Erdosteine
- Letosteine
- Mannitol
- Mesna
- Neltenexine
- Sobrerol
- Stepronin
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III