Etonitazepipne
Benzimidazole derivative
- DE: NpSG (Industrial and scientific use only)
- UK: Under Psychoactive Substances Act
- 2-[(4-Ethoxyphenyl)methyl]-5-nitro-1-(2-piperidin-1-ylethyl)benzimidazole
- 734496-28-7
- 162623834
- 7AF6EZ8PMY
- DTXSID401337650
- Interactive image
- CCOC1=CC=C(C=C1)CC2=NC3=C(N2CCN4CCCCC4)C=CC(=C3)[N+](=O)[O-]
InChI
- InChI=1S/C23H28N4O3/c1-2-30-20-9-6-18(7-10-20)16-23-24-21-17-19(27(28)29)8-11-22(21)26(23)15-14-25-12-4-3-5-13-25/h6-11,17H,2-5,12-16H2,1H3
- Key:UMGXRAISFRUVKD-UHFFFAOYSA-N
Etonitazepipne (N-piperidino etonitazene) is a benzimidazole derivative with opioid effects around 100 times more potent than morphine,[1][2] which has been sold over the internet as a designer drug.[3][4][5][6]
See also
- Etazene
- Etonitazepyne
- Isotonitazene
- Metonitazene
- Protonitazepyne
- List of benzimidazole opioids
References
- ^ Hunger A, Kebrle J, Rossi A, Hoffmann K (1960). "Benzimidazol-Derivate und verwandte Heterocyclen III. Synthese von 1-Aminoalkyl-2-benzyl-nitro-benzimidazolen". Helvetica Chimica Acta. 43 (4): 1032–1046. doi:10.1002/hlca.19600430412.
- ^ Berardinelli D, Taoussi O, Carlier J, Tini A, Zaami S, Sundermann T, et al. (July 2024). "In vitro, in vivo metabolism and quantification of the novel synthetic opioid N-piperidinyl etonitazene (etonitazepipne)". Clinical Chemistry and Laboratory Medicine. 62 (8): 1580–1590. doi:10.1515/cclm-2023-1360. PMID 38311816.
- ^ "Alert from NDEWS Web Monitoring Team: Increase in discussion of etonitazepipne". National Drug Early Warning System. Weekly Briefing (43). 9 July 2021.
- ^ "Warnings Etonitazepipne". Knowdrugs.app. 9 August 2021.
- ^ Vandeputte MM, Verougstraete N, Walther D, Glatfelter GC, Malfliet J, Baumann MH, et al. (June 2022). "First identification, chemical analysis and pharmacological characterization of N-piperidinyl etonitazene (etonitazepipne), a recent addition to the 2-benzylbenzimidazole opioid subclass". Archives of Toxicology. 96 (6): 1865–1880. doi:10.1007/s00204-022-03294-2. hdl:1854/LU-8751259. PMID 35449307. S2CID 253718213.
- ^ Calello DP, Aldy K, Jefri M, Nguyen TT, Krotulski A, Logan B, et al. (September 2022). "Identification of a novel opioid, N-piperidinyl etonitazene (etonitazepipne), in patients with suspected opioid overdose". Clinical Toxicology. 60 (9): 1067–1069. doi:10.1080/15563650.2022.2084406. PMC 9815205. PMID 35708103.
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- Enkephalinase inhibitors: Amastatin
- BL-2401
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- Propeptides: β-Lipotropin (proendorphin)
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- Others: Kyotorphin (met-enkephalin releaser/degradation stabilizer)
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