Exosome component 9

Protein-coding gene in the species Homo sapiens

EXOSC9

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
2NN6

Identifiers

Aliases

EXOSC9, PM/Scl-75, PMSCL1, RRP45, Rrp45p, p5, p6, Exosome component 9, PCH1D

External IDs

OMIM: 606180; MGI: 1355319; HomoloGene: 3693; GeneCards: EXOSC9; OMA:EXOSC9 - orthologs

Gene location (Human)

Chr.	Chromosome 4 (human)^[1]

Band	4q27	Start	121,801,318 bp^[1]
Band	4q27	End	121,817,021 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 3 (mouse)^[2]

Band	3\|3 B	Start	36,606,755 bp^[2]
Band	3\|3 B	End	36,619,876 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

secondary oocyte

Achilles tendon

gonad

testicle

buccal mucosa cell

left testis

right testis

ventricular zone

ganglionic eminence

lymph node

Top expressed in

otic vesicle

otic placode

saccule

Paneth cell

ventricular zone

trigeminal ganglion

spermatocyte

tail of embryo

endothelial cell of lymphatic vessel

condyle

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	3'-5'-exoribonuclease activity exoribonuclease activity protein binding RNA binding mRNA 3'-UTR AU-rich region binding
Cellular component	cytoplasm cytosol exosome (RNase complex) nuclear exosome (RNase complex) nuclear chromosome nucleolus extracellular exosome nucleus nucleoplasm cytoplasmic exosome (RNase complex)
Biological process	RNA processing regulation of mRNA stability nuclear polyadenylation-dependent rRNA catabolic process nuclear-transcribed mRNA catabolic process positive regulation of cell growth nuclear mRNA surveillance immune response exonucleolytic catabolism of deadenylated mRNA positive regulation of transcription by RNA polymerase II rRNA processing exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' U1 snRNA 3'-end processing U4 snRNA 3'-end processing U5 snRNA 3'-end processing nuclear polyadenylation-dependent tRNA catabolic process nuclear polyadenylation-dependent mRNA catabolic process rRNA catabolic process
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


5393


50911

Ensembl


ENSG00000123737


ENSMUSG00000027714

UniProt


Q06265


Q9JHI7

RefSeq (mRNA)


NM_001034194 NM_005033


NM_019393

RefSeq (protein)


NP_001029366 NP_005024


NP_062266

Location (UCSC)

Chr 4: 121.8 – 121.82 Mb

Chr 3: 36.61 – 36.62 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Exosome component 9, also known as EXOSC9, is a human gene, the protein product of which (sometimes called RRP45 or PM/Scl-75) is part of the exosome complex and is an autoantigen is patients with certain auto immune diseases, most notably scleromyositis.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000123737 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027714 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: EXOSC9 exosome component 9".

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Allmang C, Petfalski E, Podtelejnikov A, et al. (1999). "The yeast exosome and human PM–Scl are related complexes of 3′ → 5′ exonucleases". Genes Dev. 13 (16): 2148–58. doi:10.1101/gad.13.16.2148. PMC 316947. PMID 10465791.
Brouwer R, Allmang C, Raijmakers R, et al. (2001). "Three novel components of the human exosome". J. Biol. Chem. 276 (9): 6177–84. doi:10.1074/jbc.M007603200. hdl:20.500.11820/a03680a4-cf3a-4827-805c-447483ff4b9f. PMID 11110791.
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Brouwer R, Vree Egberts WT, Hengstman GJ, et al. (2002). "Autoantibodies directed to novel components of the PM/Scl complex, the human exosome". Arthritis Res. 4 (2): 134–8. doi:10.1186/ar389. PMC 83843. PMID 11879549.
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Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.
Raijmakers R, Renz M, Wiemann C, et al. (2004). "PM-Scl-75 is the main autoantigen in patients with the polymyositis/scleroderma overlap syndrome". Arthritis Rheum. 50 (2): 565–9. doi:10.1002/art.20056. PMID 14872500.
Lehner B, Sanderson CM (2004). "A Protein Interaction Framework for Human mRNA Degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
Tsang HT, Connell JW, Brown SE, et al. (2006). "A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex". Genomics. 88 (3): 333–46. doi:10.1016/j.ygeno.2006.04.003. PMID 16730941.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
van Dijk EL, Schilders G, Pruijn GJ (2007). "Human cell growth requires a functional cytoplasmic exosome, which is involved in various mRNA decay pathways". RNA. 13 (7): 1027–35. doi:10.1261/rna.575107. PMC 1894934. PMID 17545563.