FAM127A

Protein-coding gene in the species Homo sapiens
RTL8C
Identifiers
AliasesRTL8C, CXX1, MAR8C, MART8C, Mar8, Mart8, FAM127A, family with sequence similarity 127 member A, SIRH5, retrotransposon Gag like 8C
External IDsOMIM: 300213; MGI: 1920115; HomoloGene: 124163; GeneCards: RTL8C; OMA:RTL8C - orthologs
Gene location (Human)
X chromosome (human)
Chr.X chromosome (human)[1]
X chromosome (human)
Genomic location for RTL8C
Genomic location for RTL8C
BandXq26.3Start135,032,355 bp[1]
End135,033,546 bp[1]
Gene location (Mouse)
X chromosome (mouse)
Chr.X chromosome (mouse)[2]
X chromosome (mouse)
Genomic location for RTL8C
Genomic location for RTL8C
BandX|X A5Start52,609,999 bp[2]
End52,610,399 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • Brodmann area 10

  • frontal pole

  • right frontal lobe

  • hypothalamus

  • cingulate gyrus

  • anterior cingulate cortex

  • apex of heart

  • amygdala

  • nucleus accumbens

  • left ventricle
Top expressed in
  • hypothalamus

  • striatum of neuraxis

  • adrenal gland

  • Cortex of frontal lobe

  • cerebellar cortex

  • olfactory bulb

  • superior frontal gyrus

  • hippocampus proper

  • primary visual cortex

  • lens
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • protein binding
Cellular component
  • membrane
  • plasma membrane
  • cellular component
Biological process
  • biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

8933

72865

Ensembl

ENSG00000134590

ENSMUSG00000051851

UniProt

O15255

Q9D6I0

RefSeq (mRNA)

NM_003928
NM_001078171

NM_028375

RefSeq (protein)

NP_001071639

NP_082651

Location (UCSC)Chr X: 135.03 – 135.03 MbChr X: 52.61 – 52.61 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

CAAX box protein 1 is a protein that in humans is encoded by the FAM127A gene.[5][6][7][8]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000134590 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000051851 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Frattini A, Faranda S, Zucchi I, Vezzoni P (Jan 1998). "A low-copy repeat in Xq26 represents a novel putatively prenylated protein gene (CXX1) and its pseudogenes (DXS9914, DXS9915, and DXS9916)". Genomics. 46 (1): 167–9. doi:10.1006/geno.1997.5006. PMID 9403077.
  6. ^ Brandt J, Schrauth S, Veith AM, Froschauer A, Haneke T, Schultheis C, Gessler M, Leimeister C, Volff JN (Apr 2005). "Transposable elements as a source of genetic innovation: expression and evolution of a family of retrotransposon-derived neogenes in mammals". Gene. 345 (1): 101–11. doi:10.1016/j.gene.2004.11.022. PMID 15716091.
  7. ^ Brandt J, Veith AM, Volff JN (Aug 2005). "A family of neofunctionalized Ty3/gypsy retrotransposon genes in mammalian genomes". Cytogenet Genome Res. 110 (1–4): 307–17. doi:10.1159/000084963. PMID 16093683. S2CID 38398479.
  8. ^ "Entrez Gene: FAM127A family with sequence similarity 127, member A".

Further reading

  • Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
  • Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. Bibcode:2005Natur.434..325R. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
  • Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.


  • v
  • t
  • e