Protein-coding gene in the species Homo sapiens
| FBLIM1 |
|---|
 |
| Available structures |
|---|
| PDB | Ortholog search: PDBe RCSB |
|---|
| List of PDB id codes |
|---|
2K9U, 2W0P, 4P3W |
|
|
| Identifiers |
|---|
| Aliases | FBLIM1, CAL, FBLP-1, FBLP1, filamin binding LIM protein 1 |
|---|
| External IDs | OMIM: 607747; MGI: 1921452; HomoloGene: 56774; GeneCards: FBLIM1; OMA:FBLIM1 - orthologs |
|---|
| Gene location (Human) |
|---|
 | | Chr. | Chromosome 1 (human)[1] |
|---|
| | Band | 1p36.21 | Start | 15,756,607 bp[1] |
|---|
| End | 15,786,594 bp[1] |
|---|
|
| Gene location (Mouse) |
|---|
 | | Chr. | Chromosome 4 (mouse)[2] |
|---|
| | Band | 4|4 D3 | Start | 141,303,373 bp[2] |
|---|
| End | 141,333,407 bp[2] |
|---|
|
| RNA expression pattern |
|---|
| Bgee | | Human | Mouse (ortholog) |
|---|
| Top expressed in | - right coronary artery
- Descending thoracic aorta
- ascending aorta
- mucosa of ileum
- popliteal artery
- tibial arteries
- cardiac muscle tissue of right atrium
- saphenous vein
- pancreatic ductal cell
- left coronary artery
|
| | Top expressed in | - interventricular septum
- ascending aorta
- tunica media of zone of aorta
- aortic valve
- myocardium of ventricle
- right ventricle
- genital tubercle
- cardiac muscles
- epithelium of stomach
- left colon
|
| | More reference expression data |
|
|---|
| BioGPS |  | | More reference expression data |
|
|---|
|
| Gene ontology |
|---|
| Molecular function | - filamin binding
- protein binding
- metal ion binding
| | Cellular component | - cytoplasm
- cytosol
- cell cortex
- cytoskeleton
- stress fiber
- focal adhesion
- fibrillar center
- cell junction
| | Biological process | - regulation of integrin activation
- cell adhesion
- cell junction assembly
- regulation of cell shape
- cell-cell adhesion
| | Sources:Amigo / QuickGO |
|
| Orthologs |
|---|
| Species | Human | Mouse |
|---|
| Entrez | | |
|---|
| Ensembl | | |
|---|
| UniProt | | |
|---|
| RefSeq (mRNA) | |
|---|
NM_001024215
NM_001024216
NM_017556
NM_001350151 |
| |
|---|
NM_001163256
NM_133754
NM_001378958
NM_001378959 |
|
|---|
| RefSeq (protein) | |
|---|
NP_001019386
NP_001019387
NP_060026
NP_001337080 |
| NP_001156728
NP_598515
NP_001365887
NP_001365888
NP_001391569
|
|---|
NP_001391570
NP_001391571
NP_001391572
NP_001391573 |
|
|---|
| Location (UCSC) | Chr 1: 15.76 – 15.79 Mb | Chr 4: 141.3 – 141.33 Mb |
|---|
| PubMed search | [3] | [4] |
|---|
|
| Wikidata |
| View/Edit Human | View/Edit Mouse |
|
Filamin-binding LIM protein 1 is a protein that in humans is encoded by the FBLIM1 gene.[5][6][7]
This gene encodes a protein with an N-terminal filamin-binding domain, a central proline-rich domain, and, multiple C-terminal LIM domains. This protein localizes at cell junctions and may link cell adhesion structures to the actin cytoskeleton. This protein may be involved in the assembly and stabilization of actin-filaments and likely plays a role in modulating cell adhesion, cell morphology and cell motility. This protein also localizes to the nucleus and may affect cardiomyocyte differentiation after binding with the CSX/NKX2-5 transcription factor. Alternative splicing results in multiple transcript variants encoding different isoforms.[7]
Interactions
FBLIM1 has been shown to interact with Filamin,[8] PLEKHC1[5] and FLNB.[9]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000162458 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000006219 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b Tu Y, Wu S, Shi X, Chen K, Wu C (April 2003). "Migfilin and Mig-2 link focal adhesions to filamin and the actin cytoskeleton and function in cell shape modulation". Cell. 113 (1): 37–47. doi:10.1016/S0092-8674(03)00163-6. PMID 12679033. S2CID 15051526.
- ^ Takafuta T, Saeki M, Fujimoto TT, Fujimura K, Shapiro SS (March 2003). "A new member of the LIM protein family binds to filamin B and localizes at stress fibers". J Biol Chem. 278 (14): 12175–81. doi:10.1074/jbc.M209339200. PMID 12496242.
- ^ a b "Entrez Gene: FBLIM1 filamin binding LIM protein 1".
- ^ Tu Y, Wu Shan, Shi Xiaohua, Chen Ka, Wu Chuanyue (April 2003). "Migfilin and Mig-2 link focal adhesions to filamin and the actin cytoskeleton and function in cell shape modulation". Cell. 113 (1). United States: 37–47. doi:10.1016/S0092-8674(03)00163-6. ISSN 0092-8674. PMID 12679033. S2CID 15051526.
- ^ Takafuta T, Saeki Mari, Fujimoto Tetsuro-Takahiro, Fujimura Kingo, Shapiro Sandor S (April 2003). "A new member of the LIM protein family binds to filamin B and localizes at stress fibers". J. Biol. Chem. 278 (14). United States: 12175–81. doi:10.1074/jbc.M209339200. ISSN 0021-9258. PMID 12496242.
Further reading
- Wu C (2005). "Migfilin and its binding partners: from cell biology to human diseases". J. Cell Sci. 118 (Pt 4): 659–64. doi:10.1242/jcs.01639. PMID 15701922. S2CID 14289176.
- Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Akazawa H, Kudoh S, Mochizuki N, Takekoshi N, Takano H, Nagai T, Komuro I (2004). "A novel LIM protein Cal promotes cardiac differentiation by association with CSX/NKX2-5". J. Cell Biol. 164 (3): 395–405. doi:10.1083/jcb.200309159. PMC 2172236. PMID 14757752.
- Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
- Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Gkretsi V, Zhang Y, Tu Y, Chen K, Stolz DB, Yang Y, Watkins SC, Wu C (2005). "Physical and functional association of migfilin with cell-cell adhesions". J. Cell Sci. 118 (Pt 4): 697–710. doi:10.1242/jcs.01638. PMID 15671069.
- Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
- Oh JH, Yang JO, Hahn Y, Kim MR, Byun SS, Jeon YJ, Kim JM, Song KS, Noh SM (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674. S2CID 69278.
- Zhang Y, Tu Y, Gkretsi V, Wu C (2006). "Migfilin interacts with vasodilator-stimulated phosphoprotein (VASP) and regulates VASP localization to cell-matrix adhesions and migration". J. Biol. Chem. 281 (18): 12397–407. doi:10.1074/jbc.M512107200. PMID 16531412.
- Gregory SG, Barlow KF, McLay KE, Kaul R, Swarbreck D, Dunham A, Scott CE, Howe KL, Woodfine K (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
- Papachristou DJ, Gkretsi V, Tu Y, Shi X, Chen K, Larjava H, Rao UN, Wu C (2007). "Increased cytoplasmic level of migfilin is associated with higher grades of human leiomyosarcoma". Histopathology. 51 (4): 499–508. doi:10.1111/j.1365-2559.2007.02791.x. PMC 2768333. PMID 17711449.
