FBXO2

Protein-coding gene in the species Homo sapiens

FBXO2
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1UMH, 1UMI, 2E31, 2E32, 2E33, 2RJ2

Identifiers
AliasesFBXO2, FBG1, FBX2, Fbs1, NFB42, OCP1, F-box protein 2
External IDsOMIM: 607112; MGI: 2446216; HomoloGene: 8132; GeneCards: FBXO2; OMA:FBXO2 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for FBXO2
Genomic location for FBXO2
Band1p36.22Start11,637,018 bp[1]
End11,655,785 bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for FBXO2
Genomic location for FBXO2
Band4 E2|4 78.68 cMStart148,245,078 bp[2]
End148,250,881 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • amygdala

  • C1 segment

  • right frontal lobe

  • anterior cingulate cortex

  • caudate nucleus

  • Brodmann area 9

  • putamen

  • nucleus accumbens

  • right hemisphere of cerebellum

  • prefrontal cortex
Top expressed in
  • vestibular membrane of cochlear duct

  • utricle

  • vestibular sensory epithelium

  • facial motor nucleus

  • anterior horn of spinal cord

  • optic nerve

  • stria vascularis

  • pontine nuclei

  • medial vestibular nucleus

  • cochlea
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • amyloid-beta binding
  • carbohydrate binding
  • ubiquitin-protein transferase activity
  • protein binding
  • ubiquitin protein ligase activity
Cellular component
  • organelle membrane
  • membrane
  • SCF ubiquitin ligase complex
  • intracellular membrane-bounded organelle
  • dendritic spine
  • endoplasmic reticulum
  • cytosol
  • cytoplasm
Biological process
  • ubiquitin-dependent protein catabolic process
  • regulation of protein ubiquitination
  • proteolysis
  • SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
  • protein ubiquitination
  • ubiquitin-dependent ERAD pathway
  • glycoprotein catabolic process
  • negative regulation of cell population proliferation
  • protein polyubiquitination
  • post-translational protein modification
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

26232

230904

Ensembl

ENSG00000116661

ENSMUSG00000041556

UniProt

Q9UK22

Q80UW2

RefSeq (mRNA)

NM_012168

NM_176848

RefSeq (protein)

NP_036300

NP_789818

Location (UCSC)Chr 1: 11.64 – 11.66 MbChr 4: 148.25 – 148.25 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

F-box only protein 2 is a protein that in humans is encoded by the FBXO2 gene.[5][6][7]

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination.

The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is highly similar to the rat NFB42 (neural F Box 42 kDa) protein which is enriched in the nervous system and may play a role in maintaining neurons in a postmitotic state.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000116661 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000041556 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (Dec 1999). "Identification of a family of human F-box proteins". Curr Biol. 9 (20): 1177–9. Bibcode:1999CBio....9.1177C. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035. S2CID 7467493.
  6. ^ Winston JT, Koepp DM, Zhu C, Elledge SJ, Harper JW (Dec 1999). "A family of mammalian F-box proteins". Curr Biol. 9 (20): 1180–2. Bibcode:1999CBio....9.1180W. doi:10.1016/S0960-9822(00)80021-4. PMID 10531037. S2CID 14341845.
  7. ^ a b "Entrez Gene: FBXO2 F-box protein 2".

Further reading

  • Erhardt JA, Hynicka W, DiBenedetto A, et al. (1999). "A novel F box protein, NFB42, is highly enriched in neurons and induces growth arrest". J. Biol. Chem. 273 (52): 35222–7. doi:10.1074/jbc.273.52.35222. PMID 9857061.
  • Yoshida Y, Chiba T, Tokunaga F, et al. (2002). "E3 ubiquitin ligase that recognizes sugar chains". Nature. 418 (6896): 438–42. Bibcode:2002Natur.418..438Y. doi:10.1038/nature00890. PMID 12140560. S2CID 4424996.
  • Ilyin GP, Sérandour AL, Pigeon C, et al. (2003). "A new subfamily of structurally related human F-box proteins". Gene. 296 (1–2): 11–20. doi:10.1016/S0378-1119(02)00867-3. PMID 12383498.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Eom CY, Lehman IR (2003). "Replication-initiator protein (UL9) of the herpes simplex virus 1 binds NFB42 and is degraded via the ubiquitin-proteasome pathway". Proc. Natl. Acad. Sci. U.S.A. 100 (17): 9803–7. Bibcode:2003PNAS..100.9803E. doi:10.1073/pnas.1733876100. PMC 187846. PMID 12904574.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
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  • 1umh: Structural basis of sugar-recognizing ubiquitin ligase
    1umh: Structural basis of sugar-recognizing ubiquitin ligase