FBXO2 |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/9/93/Protein_FBXO2_PDB_1umh.png/250px-Protein_FBXO2_PDB_1umh.png) |
Available structures |
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PDB | Ortholog search: PDBe RCSB |
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List of PDB id codes |
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1UMH, 1UMI, 2E31, 2E32, 2E33, 2RJ2 |
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Identifiers |
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Aliases | FBXO2, FBG1, FBX2, Fbs1, NFB42, OCP1, F-box protein 2 |
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External IDs | OMIM: 607112; MGI: 2446216; HomoloGene: 8132; GeneCards: FBXO2; OMA:FBXO2 - orthologs |
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Gene location (Human) |
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![Chromosome 1 (human)](//upload.wikimedia.org/wikipedia/commons/thumb/d/d6/Ideogram_human_chromosome_1.svg/300px-Ideogram_human_chromosome_1.svg.png) | Chr. | Chromosome 1 (human)[1] |
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| Band | 1p36.22 | Start | 11,637,018 bp[1] |
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End | 11,655,785 bp[1] |
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Gene location (Mouse) |
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![Chromosome 4 (mouse)](//upload.wikimedia.org/wikipedia/commons/thumb/9/9c/Ideogram_house_mouse_chromosome_4.svg/260px-Ideogram_house_mouse_chromosome_4.svg.png) | Chr. | Chromosome 4 (mouse)[2] |
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| Band | 4 E2|4 78.68 cM | Start | 148,245,078 bp[2] |
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End | 148,250,881 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - amygdala
- C1 segment
- right frontal lobe
- anterior cingulate cortex
- caudate nucleus
- Brodmann area 9
- putamen
- nucleus accumbens
- right hemisphere of cerebellum
- prefrontal cortex
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| Top expressed in | - vestibular membrane of cochlear duct
- utricle
- vestibular sensory epithelium
- facial motor nucleus
- anterior horn of spinal cord
- optic nerve
- stria vascularis
- pontine nuclei
- medial vestibular nucleus
- cochlea
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| More reference expression data |
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BioGPS | ![](//upload.wikimedia.org/wikipedia/commons/thumb/f/f2/PBB_GE_FBXO2_219305_x_at_fs.png/250px-PBB_GE_FBXO2_219305_x_at_fs.png) | More reference expression data |
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Gene ontology |
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Molecular function | - amyloid-beta binding
- carbohydrate binding
- ubiquitin-protein transferase activity
- protein binding
- ubiquitin protein ligase activity
| Cellular component | - organelle membrane
- membrane
- SCF ubiquitin ligase complex
- intracellular membrane-bounded organelle
- dendritic spine
- endoplasmic reticulum
- cytosol
- cytoplasm
| Biological process | - ubiquitin-dependent protein catabolic process
- regulation of protein ubiquitination
- proteolysis
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
- protein ubiquitination
- ubiquitin-dependent ERAD pathway
- glycoprotein catabolic process
- negative regulation of cell population proliferation
- protein polyubiquitination
- post-translational protein modification
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Location (UCSC) | Chr 1: 11.64 – 11.66 Mb | Chr 4: 148.25 – 148.25 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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