Protein-coding gene in the species Homo sapiens
| FCMR |
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| Identifiers |
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| Aliases | FCMR, TOSO, FAIM3, Fc fragment of IgM receptor, Fc mu receptor, FcmuR |
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| External IDs | OMIM: 606015; MGI: 1916419; HomoloGene: 48347; GeneCards: FCMR; OMA:FCMR - orthologs |
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| Gene location (Human) |
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 | | Chr. | Chromosome 1 (human)[1] |
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| | Band | 1q32.1 | Start | 206,903,317 bp[1] |
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| End | 206,923,247 bp[1] |
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| Gene location (Mouse) |
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 | | Chr. | Chromosome 1 (mouse)[2] |
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| | Band | 1|1 E4 | Start | 130,793,406 bp[2] |
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| End | 130,808,528 bp[2] |
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| RNA expression pattern |
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| Bgee | | Human | Mouse (ortholog) |
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| Top expressed in | - spleen
- granulocyte
- lymph node
- appendix
- blood
- epithelium of nasopharynx
- bone marrow cells
- thymus
- mucosa of ileum
- tonsil
|
| | Top expressed in | - mesenteric lymph nodes
- spleen
- blood
- subcutaneous adipose tissue
- embryo
- white adipose tissue
- submandibular gland
- bone marrow
- embryo
- granulocyte
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| | More reference expression data |
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| BioGPS | |
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| Orthologs |
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| Species | Human | Mouse |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (mRNA) | |
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NM_001142472
NM_001142473
NM_001193338
NM_005449 |
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| RefSeq (protein) | |
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NP_001135945
NP_001180267
NP_005440 |
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| Location (UCSC) | Chr 1: 206.9 – 206.92 Mb | Chr 1: 130.79 – 130.81 Mb |
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| PubMed search | [3] | [4] |
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| Wikidata |
| View/Edit Human | View/Edit Mouse |
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Fc fragment of IgM receptor is a protein that in humans is encoded by the FCMR gene. [5]
Function
Fc receptors specifically bind to the Fc region of immunoglobulins (Igs) to mediate the unique functions of each Ig class. FAIM3 encodes an Fc receptor for IgM (see MIM 147020) (Kubagawa et al., 2009 [PubMed 19858324]; Shima et al., 2010 [PubMed 20042454]).
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000162894 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000042474 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: Fc fragment of IgM receptor". Retrieved 2016-03-24.
Further reading
- Sigruener A, Buechler C, Bared SM, Grandl M, Aslanidis C, Ugocsai P, Gehrmann M, Schmitz G (2007). "E-LDL upregulates TOSO expression and enhances the survival of human macrophages". Biochem. Biophys. Res. Commun. 359 (3): 723–8. doi:10.1016/j.bbrc.2007.05.169. PMID 17553462.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
