FSCN1

Protein-coding gene in the species Homo sapiens
FSCN1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1DFC, 4GP0, 4GP3, 3P53, 4GOY, 4GOV, 3LLP

Identifiers
AliasesFSCN1, FAN1, HSN, SNL, p55, fascin actin-bundling protein 1
External IDsOMIM: 602689; MGI: 1352745; HomoloGene: 48164; GeneCards: FSCN1; OMA:FSCN1 - orthologs
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for FSCN1
Genomic location for FSCN1
Band7p22.1Start5,592,816 bp[1]
End5,606,655 bp[1]
Gene location (Mouse)
Chromosome 5 (mouse)
Chr.Chromosome 5 (mouse)[2]
Chromosome 5 (mouse)
Genomic location for FSCN1
Genomic location for FSCN1
Band5 G2|5 81.84 cMStart142,946,098 bp[2]
End142,958,940 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • stromal cell of endometrium

  • ganglionic eminence

  • middle frontal gyrus

  • frontal pole

  • Brodmann area 10

  • C1 segment

  • ventricular zone

  • right frontal lobe

  • putamen

  • amygdala
Top expressed in
  • external carotid artery

  • internal carotid artery

  • abdominal wall

  • Rostral migratory stream

  • endothelial cell of lymphatic vessel

  • condyle

  • primitive streak

  • endocardial cushion

  • fossa

  • mandibular prominence
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • protein-macromolecule adaptor activity
  • actin filament binding
  • protein binding
  • actin binding
  • RNA binding
  • cadherin binding
Cellular component
  • cytoplasm
  • cell projection
  • cell-cell junction
  • filopodium
  • ruffle
  • myelin sheath
  • stress fiber
  • microvillus
  • cell junction
  • microspike
  • cell projection membrane
  • actin cytoskeleton
  • podosome
  • extracellular exosome
  • cytoskeleton
  • growth cone
  • lamellipodium
  • filamentous actin
  • cytosol
Biological process
  • regulation of microvillus assembly
  • establishment of apical/basal cell polarity
  • regulation of actin cytoskeleton organization
  • actin filament organization
  • cell motility
  • positive regulation of podosome assembly
  • actin filament bundle assembly
  • positive regulation of extracellular matrix disassembly
  • cell-cell junction assembly
  • microspike assembly
  • cell population proliferation
  • positive regulation of lamellipodium assembly
  • cell migration
  • positive regulation of filopodium assembly
  • actin cytoskeleton organization
  • anatomical structure morphogenesis
  • establishment or maintenance of cell polarity
  • cytokine-mediated signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

6624

14086

Ensembl

ENSG00000075618

ENSMUSG00000029581

UniProt

Q16658

Q61553

RefSeq (mRNA)

NM_003088

NM_007984

RefSeq (protein)

NP_003079

NP_032010

Location (UCSC)Chr 7: 5.59 – 5.61 MbChr 5: 142.95 – 142.96 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Fascin is a protein that in humans is encoded by the FSCN1 gene.[5][6][7]

Interactions

FSCN1 has been shown to interact with Low affinity nerve growth factor receptor[8] and PKC alpha.[9]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000075618 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029581 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Duh FM, Latif F, Weng Y, Geil L, Modi W, Stackhouse T, Matsumura F, Duan DR, Linehan WM, Lerman MI (Sep 1994). "cDNA cloning and expression of the human homolog of the sea urchin fascin and Drosophila singed genes which encodes an actin-bundling protein". DNA Cell Biol. 13 (8): 821–7. doi:10.1089/dna.1994.13.821. PMID 8068206.
  6. ^ Tubb BE, Bardien-Kruger S, Kashork CD, Shaffer LG, Ramagli LS, Xu J, Siciliano MJ, Bryan J (Jul 2000). "Characterization of human retinal fascin gene (FSCN2) at 17q25: close physical linkage of fascin and cytoplasmic actin genes". Genomics. 65 (2): 146–56. doi:10.1006/geno.2000.6156. PMID 10783262.
  7. ^ "Entrez Gene: FSCN1 fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)".
  8. ^ Shonukan O, Bagayogo I, McCrea P, Chao M, Hempstead B (Jun 2003). "Neurotrophin-induced melanoma cell migration is mediated through the actin-bundling protein fascin". Oncogene. 22 (23): 3616–23. doi:10.1038/sj.onc.1206561. PMID 12789270. S2CID 13116876.
  9. ^ Anilkumar N, Parsons M, Monk R, Ng T, Adams JC (Oct 2003). "Interaction of fascin and protein kinase Cα: a novel intersection in cell adhesion and motility". EMBO J. 22 (20): 5390–402. doi:10.1093/emboj/cdg521. PMC 213775. PMID 14532112.

Further reading

  • Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin". J. Infect. 24 (3): 317–20. doi:10.1016/S0163-4453(05)80037-4. PMID 1602151.
  • Yamashiro-Matsumura S, Matsumura F (1985). "Purification and characterization of an F-actin-bundling 55-kilodalton protein from HeLa cells". J. Biol. Chem. 260 (8): 5087–97. doi:10.1016/S0021-9258(18)89183-9. PMID 3886649.
  • Mosialos G, Yamashiro S, Baughman RW, Matsudaira P, Vara L, Matsumura F, Kieff E, Birkenbach M (1994). "Epstein-Barr virus infection induces expression in B lymphocytes of a novel gene encoding an evolutionarily conserved 55-kilodalton actin-bundling protein". J. Virol. 68 (11): 7320–8. doi:10.1128/JVI.68.11.7320-7328.1994. PMC 237173. PMID 7933116.
  • Mosialos G, Birkenbach M, Ayehunie S, Matsumura F, Pinkus GS, Kieff E, Langhoff E (1996). "Circulating human dendritic cells differentially express high levels of a 55-kd actin-bundling protein". Am. J. Pathol. 148 (2): 593–600. PMC 1861678. PMID 8579121.
  • Yamakita Y, Ono S, Matsumura F, Yamashiro S (1996). "Phosphorylation of human fascin inhibits its actin binding and bundling activities". J. Biol. Chem. 271 (21): 12632–8. doi:10.1074/jbc.271.21.12632. PMID 8647875.
  • Lin XH, Grako KA, Burg MA, Stallcup WB (1997). "NG2 proteoglycan and the actin-binding protein fascin define separate populations of actin-containing filopodia and lamellipodia during cell spreading and migration". Mol. Biol. Cell. 7 (12): 1977–93. doi:10.1091/mbc.7.12.1977. PMC 276044. PMID 8970159.
  • Ono S, Yamakita Y, Yamashiro S, Matsudaira PT, Gnarra JR, Obinata T, Matsumura F (1997). "Identification of an actin binding region and a protein kinase C phosphorylation site on human fascin". J. Biol. Chem. 272 (4): 2527–33. doi:10.1074/jbc.272.4.2527. PMID 8999969.
  • Pinkus GS, Pinkus JL, Langhoff E, Matsumura F, Yamashiro S, Mosialos G, Said JW (1997). "Fascin, a sensitive new marker for Reed-Sternberg cells of hodgkin's disease. Evidence for a dendritic or B cell derivation?". Am. J. Pathol. 150 (2): 543–62. PMC 1858289. PMID 9033270.
  • Ross R, Ross XL, Schwing J, Längin T, Reske-Kunz AB (1998). "The actin-bundling protein fascin is involved in the formation of dendritic processes in maturing epidermal Langerhans cells". J. Immunol. 160 (8): 3776–82. doi:10.4049/jimmunol.160.8.3776. PMID 9558080.
  • Sonderbye L, Meehan S, Palsson R, Ahsan N, Ladefoged J, Langhoff E (1998). "Immunohistochemical study of actin binding protein (p55) in the human kidney". Transplantation. 65 (7): 1004–8. doi:10.1097/00007890-199804150-00025. PMID 9565110.
  • Kempf W, Levi E, Kamarashev J, Kutzner H, Pfeifer W, Petrogiannis-Haliotis T, Burg G, Kadin ME (2003). "Fascin expression in CD30-positive cutaneous lymphoproliferative disorders". J. Cutan. Pathol. 29 (5): 295–300. doi:10.1034/j.1600-0560.2002.290507.x. PMID 12100631. S2CID 31623792.
  • Goncharuk VN, Ross JS, Carlson JA (2003). "Actin-binding protein fascin expression in skin neoplasia". J. Cutan. Pathol. 29 (7): 430–8. doi:10.1034/j.1600-0560.2002.290708.x. PMID 12139639. S2CID 26565797.
  • Pelosi G, Pastorino U, Pasini F, Maissoneuve P, Fraggetta F, Iannucci A, Sonzogni A, De Manzoni G, Terzi A, Durante E, Bresaola E, Pezzella F, Viale G (2003). "Independent prognostic value of fascin immunoreactivity in stage I nonsmall cell lung cancer". Br. J. Cancer. 88 (4): 537–47. doi:10.1038/sj.bjc.6600731. PMC 2377175. PMID 12592367.
  • Shonukan O, Bagayogo I, McCrea P, Chao M, Hempstead B (2003). "Neurotrophin-induced melanoma cell migration is mediated through the actin-bundling protein fascin". Oncogene. 22 (23): 3616–23. doi:10.1038/sj.onc.1206561. PMID 12789270. S2CID 13116876.
  • Bros M, Ross XL, Pautz A, Reske-Kunz AB, Ross R (2003). "The human fascin gene promoter is highly active in mature dendritic cells due to a stage-specific enhancer". J. Immunol. 171 (4): 1825–34. doi:10.4049/jimmunol.171.4.1825. PMID 12902483.
  • Anilkumar N, Parsons M, Monk R, Ng T, Adams JC (2004). "Interaction of fascin and protein kinase Cα: a novel intersection in cell adhesion and motility". EMBO J. 22 (20): 5390–402. doi:10.1093/emboj/cdg521. PMC 213775. PMID 14532112.
  • Ishikawa R, Sakamoto T, Ando T, Higashi-Fujime S, Kohama K (2003). "Polarized actin bundles formed by human fascin-1: their sliding and disassembly on myosin II and myosin V in vitro". J. Neurochem. 87 (3): 676–85. doi:10.1046/j.1471-4159.2003.02058.x. PMID 14535950. S2CID 927239.
  • v
  • t
  • e
  • 1dfc: CRYSTAL STRUCTURE OF HUMAN FASCIN, AN ACTIN-CROSSLINKING PROTEIN
    1dfc: CRYSTAL STRUCTURE OF HUMAN FASCIN, AN ACTIN-CROSSLINKING PROTEIN


Stub icon

This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by expanding it.

  • v
  • t
  • e