GET4

Protein-coding gene in the species Homo sapiens
GET4
Identifiers
AliasesGET4, C7orf20, CEE, TRC35, CGI-20, golgi to ER traffic protein 4, guided entry of tail-anchored proteins factor 4
External IDsOMIM: 612056; MGI: 1914854; HomoloGene: 41080; GeneCards: GET4; OMA:GET4 - orthologs
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for GET4
Genomic location for GET4
Band7p22.3Start876,554 bp[1]
End896,436 bp[1]
Gene location (Mouse)
Chromosome 5 (mouse)
Chr.Chromosome 5 (mouse)[2]
Chromosome 5 (mouse)
Genomic location for GET4
Genomic location for GET4
Band5|5 G2Start139,238,079 bp[2]
End139,255,806 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • left testis

  • right testis

  • pituitary gland

  • right adrenal cortex

  • left adrenal cortex

  • right uterine tube

  • anterior pituitary

  • right lobe of liver

  • skin of leg

  • skin of abdomen
Top expressed in
  • bone marrow

  • yolk sac

  • epiblast

  • layer of retina

  • neural layer of retina

  • proximal tubule

  • neural tube

  • adrenal gland

  • limb

  • lip
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
  • chaperone binding
Cellular component
  • BAT3 complex
  • cytosol
  • cytoplasm
  • nucleoplasm
  • nucleolus
Biological process
  • cytoplasmic sequestering of protein
  • tail-anchored membrane protein insertion into ER membrane
  • maintenance of unfolded protein involved in ERAD pathway
  • protein insertion into ER membrane
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

51608

67604

Ensembl

ENSG00000239857

ENSMUSG00000025858

UniProt

Q7L5D6

Q9D1H7

RefSeq (mRNA)

NM_015949

NM_001163316
NM_026269
NM_001359238

RefSeq (protein)

NP_057033

NP_001156788
NP_080545
NP_001346167

Location (UCSC)Chr 7: 0.88 – 0.9 MbChr 5: 139.24 – 139.26 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

GET4 is a protein that in humans is encoded by the GET4 gene.[5][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000239857 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025858 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (Aug 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
  6. ^ "Entrez Gene: C7orf20 chromosome 7 open reading frame 20".

Further reading

  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  • Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.


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