GNL2

Protein-coding gene in the species Homo sapiens

GNL2
Identifiers
AliasesGNL2, HUMAUANTIG, NGP1, Ngp-1, Nog2, Nug2, G protein nucleolar 2
External IDsOMIM: 609365; MGI: 2385207; HomoloGene: 6858; GeneCards: GNL2; OMA:GNL2 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for GNL2
Genomic location for GNL2
Band1p34.3Start37,566,816 bp[1]
End37,595,937 bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for GNL2
Genomic location for GNL2
Band4|4 D2.2Start124,910,378 bp[2]
End124,949,173 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • tendon of biceps brachii

  • gingival epithelium

  • sural nerve

  • Achilles tendon

  • gonad

  • amniotic fluid

  • olfactory zone of nasal mucosa

  • gastrocnemius muscle

  • epithelium of nasopharynx

  • anterior pituitary
Top expressed in
  • condyle

  • fossa

  • saccule

  • otic placode

  • internal carotid artery

  • external carotid artery

  • supraoptic nucleus

  • lens

  • spermatocyte

  • primary oocyte
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • nucleotide binding
  • GTP binding
  • RNA binding
  • GTPase activity
Cellular component
  • membrane
  • nucleus
  • nucleolus
  • integral component of membrane
Biological process
  • ribosome biogenesis
  • biological process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

29889

230737

Ensembl

ENSG00000134697

ENSMUSG00000028869

UniProt

Q13823

Q99LH1

RefSeq (mRNA)

NM_013285
NM_001323623
NM_001323624

NM_145552

RefSeq (protein)

NP_001310552
NP_001310553
NP_037417

NP_663527

Location (UCSC)Chr 1: 37.57 – 37.6 MbChr 4: 124.91 – 124.95 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Nucleolar GTP-binding protein 2 is a protein that in humans is encoded by the GNL2 gene.[5][6]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000134697 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028869 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Racevskis J, Dill A, Stockert R, Fineberg SA (Mar 1997). "Cloning of a novel nucleolar guanosine 5'-triphosphate binding protein autoantigen from a breast tumor". Cell Growth Differ. 7 (2): 271–80. PMID 8822211.
  6. ^ "Entrez Gene: GNL2 guanine nucleotide binding protein-like 2 (nucleolar)".

Further reading

  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
  • Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Scherl A, Couté Y, Déon C, et al. (2003). "Functional proteomic analysis of human nucleolus". Mol. Biol. Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.
  • Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. Bibcode:2002CBio...12....1A. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.


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