GON4L

Protein-coding gene in the species Homo sapiens
GON4L
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1UG2

Identifiers
AliasesGON4L, GON-4, GON4, YARP, gon-4 like
External IDsOMIM: 610393; MGI: 1917579; HomoloGene: 13002; GeneCards: GON4L; OMA:GON4L - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for GON4L
Genomic location for GON4L
Band1q22Start155,749,659 bp[1]
End155,859,400 bp[1]
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)[2]
Chromosome 3 (mouse)
Genomic location for GON4L
Genomic location for GON4L
Band3|3 F1Start88,835,231 bp[2]
End88,910,103 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • sural nerve

  • granulocyte

  • epithelium of colon

  • buccal mucosa cell

  • Achilles tendon

  • right uterine tube

  • apex of heart

  • anterior pituitary

  • gastric mucosa

  • right lobe of thyroid gland
Top expressed in
  • saccule

  • zygote

  • otic vesicle

  • primary oocyte

  • otic placode

  • spermatocyte

  • secondary oocyte

  • neural layer of retina

  • tail of embryo

  • ventricular zone
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • DNA binding
  • transcription corepressor activity
  • DNA-binding transcription factor activity, RNA polymerase II-specific
Cellular component
  • nucleoplasm
  • nuclear body
  • nucleus
Biological process
  • transcription, DNA-templated
  • regulation of transcription, DNA-templated
  • B cell differentiation
  • negative regulation of transcription, DNA-templated
  • regulation of transcription by RNA polymerase II
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

54856

76022

Ensembl

ENSG00000116580

ENSMUSG00000054199

UniProt

Q3T8J9

Q9DB00

RefSeq (mRNA)
NM_001037533
NM_001282856
NM_001282858
NM_001282860
NM_001282861

NM_032292
NM_025174

NM_001242372
NM_027389

RefSeq (protein)

NP_001269785
NP_001269787
NP_001269789
NP_001269790
NP_115668

NP_001229301
NP_081665

Location (UCSC)Chr 1: 155.75 – 155.86 MbChr 3: 88.84 – 88.91 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

GON-4-like protein is a protein that in humans is encoded by the GON4L gene.[5][6] It is a nuclear protein containing two serine phosphosites and a lysine-glutamine cross-link [7] and is thought to be a transcription factor.[8]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000116580 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000054199 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kuryshev VY, Vorobyov E, Zink D, Schmitz J, Rozhdestvensky TS, Münstermann E, Ernst U, Wellenreuther R, Moosmayer P, Bechtel S, Schupp I, Horst J, Korn B, Poustka A, Wiemann S (August 2006). "An anthropoid-specific segmental duplication on human chromosome 1q22". Genomics. 88 (2): 143–51. doi:10.1016/j.ygeno.2006.02.002. PMID 16545939.
  6. ^ "Entrez Gene: GON4L gon-4-like (C. elegans)".
  7. ^ "Expasy listing: GON4L gon-4-like".
  8. ^ Online Mendelian Inheritance in Man (OMIM): GON4L gon-4-like - 610393

Further reading

  • Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Nagase T, Kikuno R, Nakayama M, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (4): 273–81. doi:10.1093/dnares/7.4.271. PMID 10997877.
  • Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (March 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMC 311072. PMID 11230166.
  • Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. (December 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, et al. (January 2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, et al. (October 2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Gregory SG, Barlow KF, McLay KE, Kaul R, Swarbreck D, Dunham A, et al. (May 2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.


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