GPSM1

Protein-coding gene in the species Homo sapiens
GPSM1
Identifiers
AliasesGPSM1, AGS3, G-protein signaling modulator 1, G protein signaling modulator 1
External IDsOMIM: 609491; MGI: 1915089; HomoloGene: 16987; GeneCards: GPSM1; OMA:GPSM1 - orthologs
Gene location (Human)
Chromosome 9 (human)
Chr.Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for GPSM1
Genomic location for GPSM1
Band9q34.3Start136,327,476 bp[1]
End136,359,605 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for GPSM1
Genomic location for GPSM1
Band2|2 A3Start26,205,527 bp[2]
End26,238,249 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • tibia

  • cardiac muscle tissue of right atrium

  • right hemisphere of cerebellum

  • retinal pigment epithelium

  • apex of heart

  • myocardium of left ventricle

  • ganglionic eminence

  • cerebellar vermis

  • sural nerve

  • right auricle
Top expressed in
  • Rostral migratory stream

  • neural layer of retina

  • saccule

  • barrel cortex

  • cerebellar cortex

  • olfactory bulb

  • atrioventricular valve

  • fossa

  • otic placode

  • substantia nigra
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
  • GTPase regulator activity
  • GDP-dissociation inhibitor activity
Cellular component
  • cytoplasm
  • cytosol
  • Golgi apparatus
  • endoplasmic reticulum
  • membrane
  • Golgi membrane
  • endoplasmic reticulum membrane
  • plasma membrane
  • cell cortex
  • protein-containing complex
Biological process
  • multicellular organism development
  • cell differentiation
  • nervous system development
  • positive regulation of macroautophagy
  • negative regulation of GTPase activity
  • negative regulation of guanyl-nucleotide exchange factor activity
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

26086

67839

Ensembl

ENSG00000160360

ENSMUSG00000026930

UniProt

Q86YR5

Q6IR34

RefSeq (mRNA)

NM_001145638
NM_001145639
NM_001200003
NM_015597

NM_001199146
NM_001199147
NM_153410
NM_001355574
NM_001355575

NM_001355576

RefSeq (protein)

NP_001139110
NP_001139111
NP_001186932
NP_056412

NP_001186075
NP_001186076
NP_700459
NP_001342503
NP_001342504

NP_001342505

Location (UCSC)Chr 9: 136.33 – 136.36 MbChr 2: 26.21 – 26.24 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

G-protein-signaling modulator 1 is a protein that in humans is encoded by the GPSM1 gene.[5][6][7]

G proteins propagate intracellular signals initiated by G protein-coupled receptors. GPSM1, a receptor-independent activator of G protein signaling, is one of several factors that influence the basal activity of G protein signaling systems (Pizzinat et al., 2001).[supplied by OMIM][7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000160360 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026930 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Pizzinat N, Takesono A, Lanier SM (May 2001). "Identification of a truncated form of the G-protein regulator AGS3 in heart that lacks the tetratricopeptide repeat domains". J Biol Chem. 276 (20): 16601–10. doi:10.1074/jbc.M007573200. PMID 11278352.
  6. ^ Peterson YK, Bernard ML, Ma H, Hazard S III, Graber SG, Lanier SM (Nov 2000). "Stabilization of the GDP-bound conformation of Gialpha by a peptide derived from the G-protein regulatory motif of AGS3". J Biol Chem. 275 (43): 33193–6. doi:10.1074/jbc.C000509200. PMID 10969064.
  7. ^ a b "Entrez Gene: GPSM1 G-protein signalling modulator 1 (AGS3-like, C. elegans)".

Further reading

  • Natochin M, Lester B, Peterson YK, et al. (2001). "AGS3 inhibits GDP dissociation from galpha subunits of the Gi family and rhodopsin-dependent activation of transducin". J. Biol. Chem. 275 (52): 40981–5. doi:10.1074/jbc.M006478200. PMID 11024022.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Pattingre S, De Vries L, Bauvy C, et al. (2003). "The G-protein regulator AGS3 controls an early event during macroautophagy in human intestinal HT-29 cells". J. Biol. Chem. 278 (23): 20995–1002. doi:10.1074/jbc.M300917200. PMID 12642577.
  • Kaushik R, Yu F, Chia W, et al. (2004). "Subcellular Localization of LGN During Mitosis: Evidence for Its Cortical Localization in Mitotic Cell Culture Systems and Its Requirement for Normal Cell Cycle Progression". Mol. Biol. Cell. 14 (8): 3144–55. doi:10.1091/mbc.E03-04-0212. PMC 181556. PMID 12925752.
  • Adhikari A, Sprang SR (2004). "Thermodynamic characterization of the binding of activator of G protein signaling 3 (AGS3) and peptides derived from AGS3 with G alpha i1". J. Biol. Chem. 278 (51): 51825–32. doi:10.1074/jbc.M306300200. PMID 14530282.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Du Q, Macara IG (2004). "Mammalian Pins is a conformational switch that links NuMA to heterotrimeric G proteins". Cell. 119 (4): 503–16. doi:10.1016/j.cell.2004.10.028. PMID 15537540. S2CID 12900159.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Izaki T, Kamakura S, Kohjima M, Sumimoto H (2006). "Two forms of human Inscuteable-related protein that links Par3 to the Pins homologues LGN and AGS3". Biochem. Biophys. Res. Commun. 341 (4): 1001–6. doi:10.1016/j.bbrc.2006.01.050. PMID 16458856.


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