GRIPAP1

Protein-coding gene in the species Homo sapiens
GRIPAP1
Identifiers
AliasesGRIPAP1, GRASP-1, GRIP1 associated protein 1
External IDsOMIM: 300408; MGI: 1859616; HomoloGene: 41348; GeneCards: GRIPAP1; OMA:GRIPAP1 - orthologs
Gene location (Human)
X chromosome (human)
Chr.X chromosome (human)[1]
X chromosome (human)
Genomic location for GRIPAP1
Genomic location for GRIPAP1
BandXp11.23Start48,973,720 bp[1]
End49,002,264 bp[1]
Gene location (Mouse)
X chromosome (mouse)
Chr.X chromosome (mouse)[2]
X chromosome (mouse)
Genomic location for GRIPAP1
Genomic location for GRIPAP1
BandX A1.1|X 3.51 cMStart7,656,004 bp[2]
End7,686,806 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right hemisphere of cerebellum

  • right frontal lobe

  • sural nerve

  • anterior pituitary

  • cingulate gyrus

  • anterior cingulate cortex

  • Brodmann area 9

  • prefrontal cortex

  • granulocyte

  • hypothalamus
Top expressed in
  • granulocyte

  • neural layer of retina

  • superior frontal gyrus

  • primary visual cortex

  • dentate gyrus of hippocampal formation granule cell

  • cerebellar cortex

  • yolk sac

  • nucleus of stria terminalis

  • ventricular zone

  • central gray substance of midbrain
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • protein binding
  • molecular function
Cellular component
  • endosome
  • blood microparticle
  • nucleoplasm
  • cytosol
  • intracellular membrane-bounded organelle
  • postsynaptic recycling endosome
  • membrane
  • cell junction
  • axon
  • dendrite
  • early endosome membrane
  • cell projection
  • synapse
  • recycling endosome membrane
  • glutamatergic synapse
  • extrinsic component of postsynaptic early endosome membrane
Biological process
  • neurotransmitter receptor transport, endosome to postsynaptic membrane
  • regulation of modification of synaptic structure
  • transport
  • protein transport
  • biological process
  • regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane
  • regulation of recycling endosome localization within postsynapse
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

56850

54645

Ensembl

ENSG00000068400

ENSMUSG00000031153

UniProt

Q4V328

Q8VD04

RefSeq (mRNA)

NM_020137
NM_207672

NM_001290455
NM_207670
NM_001359289
NM_001359290
NM_001359291

NM_001359293

RefSeq (protein)

NP_064522

NP_001277384
NP_997553
NP_001346218
NP_001346219
NP_001346220

NP_001346222

Location (UCSC)Chr X: 48.97 – 49 MbChr X: 7.66 – 7.69 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

GRIP1-associated protein 1 is a protein that in humans is encoded by the GRIPAP1 gene.[5][6]

Function

GRASP1 is a neuron-specific guanine nucleotide exchange factor for the Ras family of small G proteins (RasGEF) and is associated with the GRIP/AMPA receptor complex in brain (Ye et al., 2000).[supplied by OMIM][6]

Interactions

GRIPAP1 has been shown to interact with GRIP1.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000068400 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031153 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Ye B, Liao D, Zhang X, Zhang P, Dong H, Huganir RL (Aug 2000). "GRASP-1: a neuronal RasGEF associated with the AMPA receptor/GRIP complex". Neuron. 26 (3): 603–17. doi:10.1016/S0896-6273(00)81198-8. PMID 10896157.
  6. ^ a b "Entrez Gene: GRIPAP1 GRIP1 associated protein 1".

Further reading

  • Hirosawa M, Nagase T, Ishikawa K, Kikuno R, Nomura N, Ohara O (1999). "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain". DNA Res. 6 (5): 329–36. doi:10.1093/dnares/6.5.329. PMID 10574461.
  • Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  • Kino T, Slobodskaya O, Pavlakis GN, Chrousos GP (2002). "Nuclear receptor coactivator p160 proteins enhance the HIV-1 long terminal repeat promoter by bridging promoter-bound factors and the Tat-P-TEFb complex". J. Biol. Chem. 277 (4): 2396–405. doi:10.1074/jbc.M106312200. PMID 11704662.
  • Hirbec H, Perestenko O, Nishimune A, Meyer G, Nakanishi S, Henley JM, Dev KK (2002). "The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs". J. Biol. Chem. 277 (18): 15221–4. doi:10.1074/jbc.C200112200. hdl:2262/89271. PMID 11891216.
  • Ye B, Sugo N, Hurn PD, Huganir RL (2002). "Physiological and pathological caspase cleavage of the neuronal RasGEF GRASP-1 as detected using a cleavage site-specific antibody". Neuroscience. 114 (1): 217–27. doi:10.1016/S0306-4522(02)00142-2. PMID 12207967. S2CID 39432674.
  • Coutts AS, MacKenzie E, Griffith E, Black DM (2003). "TES is a novel focal adhesion protein with a role in cell spreading". J. Cell Sci. 116 (Pt 5): 897–906. doi:10.1242/jcs.00278. PMID 12571287.
  • Nakata A, Ito T, Nagata M, Hori S, Sekimizu K (2004). "GRIP1tau, a novel PDZ domain-containing transcriptional activator, cooperates with the testis-specific transcription elongation factor SII-T1". Genes Cells. 9 (11): 1125–35. doi:10.1111/j.1365-2443.2004.00795.x. PMID 15507123.
  • Barrios-Rodiles M, Brown KR, Ozdamar B, Bose R, Liu Z, Donovan RS, Shinjo F, Liu Y, Dembowy J, Taylor IW, Luga V, Przulj N, Robinson M, Suzuki H, Hayashizaki Y, Jurisica I, Wrana JL (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
  • Stinton LM, Selak S, Fritzler MJ (2005). "Identification of GRASP-1 as a novel 97 kDa autoantigen localized to endosomes". Clin. Immunol. 116 (2): 108–17. doi:10.1016/j.clim.2005.03.021. PMID 15897011.


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