HIST2H3A

Protein-coding gene in the species Homo sapiens
H3C15
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2IIJ, 2X4W, 2X4X, 2X4Y, 3AV1, 3DB3, 3MO8, 3R93, 4MZF, 4MZG, 4MZH, 4OUC, 5BO0, 2HIO, 5B0Z, 2ARO, 1EQZ, 1HQ3, 4KGC, 1TZY, 4UUZ, 2F8N, 5B0Y, 4LD9, 5B40, 5CIU

Identifiers
AliasesH3C15, H3/n, H3/o, histone cluster 2, H3a, histone cluster 2 H3 family member a, HIST2H3A, H3 clustered histone 15, H3C14, H3C13
External IDsMGI: 2448329; HomoloGene: 133885; GeneCards: H3C15; OMA:H3C15 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for H3C15
Genomic location for H3C15
Band1q21.2Start149,852,608 bp[1]
End149,853,125 bp[1]
Gene location (Mouse)
Chromosome 13 (mouse)
Chr.Chromosome 13 (mouse)[2]
Chromosome 13 (mouse)
Genomic location for H3C15
Genomic location for H3C15
Band13 A3.1|13 9.78 cMStart23,728,222 bp[2]
End23,729,482 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • bone marrow cells

  • testicle

  • gonad

  • ganglionic eminence

  • ventricular zone

  • apex of heart

  • olfactory zone of nasal mucosa

  • corpus callosum

  • islet of Langerhans

  • Achilles tendon
Top expressed in
  • zygote

  • spermatocyte

  • embryo

  • primary oocyte

  • secondary oocyte

  • embryo

  • maxillary prominence

  • mandibular prominence

  • primitive streak

  • morula
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • protein heterodimerization activity
  • DNA binding
  • histone binding
  • protein binding
  • chromatin binding
  • nucleosomal DNA binding
Cellular component
  • extracellular exosome
  • extracellular region
  • nucleoplasm
  • chromosome
  • nucleosome
  • nucleus
  • chromatin
Biological process
  • epigenetic maintenance of chromatin in transcription-competent conformation
  • blood coagulation
  • rDNA heterochromatin assembly
  • nucleosome assembly
  • negative regulation of gene expression, epigenetic
  • negative regulation of transcription by RNA polymerase II
  • chromatin organization
  • regulation of gene silencing by miRNA
  • interleukin-7-mediated signaling pathway
  • regulation of megakaryocyte differentiation
  • regulation of hematopoietic stem cell differentiation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

333932

260423

Ensembl

ENSG00000203852

ENSMUSG00000100210

UniProt

Q71DI3

P84228

RefSeq (mRNA)

NM_001005464

NM_013548

RefSeq (protein)

NP_066403
NP_001116847

NP_473386
NP_835734
NP_783584
NP_835510
NP_835587

NP_038576
NP_835511
NP_835512

Location (UCSC)Chr 1: 149.85 – 149.85 MbChr 13: 23.73 – 23.73 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Histone cluster 2 H3 family member a is a protein that in humans is encoded by the HIST2H3A gene. [5]

Function

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in a histone cluster on human chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this record represents the centromeric copy. [provided by RefSeq, Aug 2015].

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000203852 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000100210 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Histone cluster 2 H3 family member a". Retrieved 2018-08-05.

Further reading

  • Ruthenburg AJ, Wang W, Graybosch DM, Li H, Allis CD, Patel DJ, Verdine GL (August 2006). "Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex". Nat. Struct. Mol. Biol. 13 (8): 704–12. doi:10.1038/nsmb1119. PMC 4698793. PMID 16829959.
  • Couture JF, Collazo E, Trievel RC (August 2006). "Molecular recognition of histone H3 by the WD40 protein WDR5". Nat. Struct. Mol. Biol. 13 (8): 698–703. doi:10.1038/nsmb1116. PMID 16829960. S2CID 26165068.
  • Rodriguez-Collazo P, Snyder SK, Chiffer RC, Zlatanova J, Leuba SH, Smith CL (January 2008). "cAMP signaling induces rapid loss of histone H3 phosphorylation in mammary adenocarcinoma-derived cell lines". Exp. Cell Res. 314 (1): 1–10. doi:10.1016/j.yexcr.2007.09.011. PMC 4426871. PMID 17950276.
  • Ho CC, Cheng CC, Liu YH, Pei RJ, Hsu YH, Yeh KT, Ho LC, Tsai MC, Lai YS (2008). "Possible relation between histone 3 and cytokeratin 18 in human hepatocellular carcinoma". In Vivo. 22 (4): 457–62. PMID 18712172.
  • Song JJ, Kingston RE (December 2008). "WDR5 interacts with mixed lineage leukemia (MLL) protein via the histone H3-binding pocket". J. Biol. Chem. 283 (50): 35258–64. doi:10.1074/jbc.M806900200. PMC 2596411. PMID 18840606.
  • Xie W, Song C, Young NL, Sperling AS, Xu F, Sridharan R, Conway AE, Garcia BA, Plath K, Clark AT, Grunstein M (February 2009). "Histone h3 lysine 56 acetylation is linked to the core transcriptional network in human embryonic stem cells". Mol. Cell. 33 (4): 417–27. doi:10.1016/j.molcel.2009.02.004. PMC 2671231. PMID 19250903.
  • Loomis RJ, Naoe Y, Parker JB, Savic V, Bozovsky MR, Macfarlan T, Manley JL, Chakravarti D (February 2009). "Chromatin binding of SRp20 and ASF/SF2 and dissociation from mitotic chromosomes is modulated by histone H3 serine 10 phosphorylation". Mol. Cell. 33 (4): 450–61. doi:10.1016/j.molcel.2009.02.003. PMC 2667802. PMID 19250906.
  • Suphioglu C, Sadli N, Coonan D, Kumar L, De Mel D, Lesheim J, Sinclair AJ, Ackland L (February 2010). "Zinc and DHA have opposing effects on the expression levels of histones H3 and H4 in human neuronal cells". Br. J. Nutr. 103 (3): 344–51. doi:10.1017/S0007114509991826. hdl:10536/DRO/DU:30023162. PMID 19747413.


  • v
  • t
  • e

This article incorporates text from the United States National Library of Medicine, which is in the public domain.