HNRNPLL

Protein-coding gene in the species Homo sapiens
HNRNPLL
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

1WEX, 2E5I

Identifiers
AliasesHNRNPLL, HNRPLL, SRRF, heterogeneous nuclear ribonucleoprotein L like
External IDsOMIM: 611208; MGI: 1919942; HomoloGene: 26701; GeneCards: HNRNPLL; OMA:HNRNPLL - orthologs
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for HNRNPLL
Genomic location for HNRNPLL
Band2p22.1Start38,561,969 bp[1]
End38,603,586 bp[1]
Gene location (Mouse)
Chromosome 17 (mouse)
Chr.Chromosome 17 (mouse)[2]
Chromosome 17 (mouse)
Genomic location for HNRNPLL
Genomic location for HNRNPLL
Band17|17 E3Start80,336,916 bp[2]
End80,369,763 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • ventricular zone

  • ganglionic eminence

  • pancreatic epithelial cell

  • cartilage tissue

  • parotid gland

  • tail of epididymis

  • left testis

  • right testis

  • saphenous vein

  • gonad
Top expressed in
  • medial ganglionic eminence

  • primitive streak

  • abdominal wall

  • somite

  • barrel cortex

  • condyle

  • tail of embryo

  • fossa

  • superior cervical ganglion

  • epiblast
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • protein binding
  • mRNA binding
  • nucleic acid binding
  • RNA binding
Cellular component
  • membrane
  • nucleus
Biological process
  • positive regulation of RNA splicing
  • mRNA processing
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

92906

72692

Ensembl

ENSG00000143889

ENSMUSG00000024095

UniProt

Q8WVV9

Q921F4

RefSeq (mRNA)

NM_001142650
NM_138394

NM_144802

RefSeq (protein)

NP_001136122
NP_612403

NP_659051

Location (UCSC)Chr 2: 38.56 – 38.6 MbChr 17: 80.34 – 80.37 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Heterogeneous nuclear ribonucleoprotein L-like is a protein that in humans is encoded by the HNRNPLL gene.[5]

Function

HNRNPLL is a master regulator of activation-induced alternative splicing in T cells. In particular, it alters splicing of CD45 (PTPRC; MIM 151460), a tyrosine phosphatase essential for T-cell development and activation.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000143889 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024095 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Heterogeneous nuclear ribonucleoprotein L-like".
  6. ^ Oberdoerffer S, Moita LF, Neems D, Freitas RP, Hacohen N, Rao A (August 2008). "Regulation of CD45 alternative splicing by heterogeneous ribonucleoprotein, hnRNPLL". Science. 321 (5889): 686–91. Bibcode:2008Sci...321..686O. doi:10.1126/science.1157610. PMC 2791692. PMID 18669861.

Further reading

  • Lai Y, Song M, Hakala K, Weintraub ST, Shiio Y (November 2011). "Proteomic dissection of the von Hippel-Lindau (VHL) interactome". Journal of Proteome Research. 10 (11): 5175–82. doi:10.1021/pr200642c. PMC 3208728. PMID 21942715.
  • Topp JD, Jackson J, Melton AA, Lynch KW (October 2008). "A cell-based screen for splicing regulators identifies hnRNP LL as a distinct signal-induced repressor of CD45 variable exon 4". RNA. 14 (10): 2038–49. doi:10.1261/rna.1212008. PMC 2553740. PMID 18719244.
  • Wu Z, Yates AL, Hoyne GF, Goodnow CC (July 2010). "Consequences of increased CD45RA and RC isoforms for TCR signaling and peripheral T cell deficiency resulting from heterogeneous nuclear ribonucleoprotein L-like mutation". Journal of Immunology. 185 (1): 231–8. doi:10.4049/jimmunol.0903625. PMID 20505149.
  • Fedorova OA, Moiseeva TN, Nikiforov AA, Tsimokha AS, Livinskaya VA, Hodson M, Bottrill A, Evteeva IN, Ermolayeva JB, Kuznetzova IM, Turoverov KK, Eperon I, Barlev NA (December 2011). "Proteomic analysis of the 20S proteasome (PSMA3)-interacting proteins reveals a functional link between the proteasome and mRNA metabolism". Biochemical and Biophysical Research Communications. 416 (3–4): 258–65. doi:10.1016/j.bbrc.2011.10.126. PMID 22079093.
  • Shur I, Ben-Avraham D, Benayahu D (June 2004). "Alternatively spliced isoforms of a novel stromal RNA regulating factor". Gene. 334: 113–21. doi:10.1016/j.gene.2004.03.012. PMID 15256261.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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