HNRPA3

Protein-coding gene in the species Homo sapiens

HNRNPA3
Identifiers
AliasesHNRNPA3, 2610510D13Rik, D10S102, FBRNP, HNRPA3, heterogeneous nuclear ribonucleoprotein A3
External IDsOMIM: 605372; MGI: 1917171; GeneCards: HNRNPA3; OMA:HNRNPA3 - orthologs
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for HNRNPA3
Genomic location for HNRNPA3
Band2q31.2Start177,212,563 bp[1]
End177,223,958 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for HNRNPA3
Genomic location for HNRNPA3
Band2|2 C3Start75,489,605 bp[2]
End75,499,751 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • ganglionic eminence

  • ventricular zone

  • right testis

  • left testis

  • monocyte

  • Brodmann area 23

  • left ovary

  • left lobe of thyroid gland

  • right lobe of thyroid gland

  • epithelium of colon
Top expressed in
  • tail of embryo

  • neural layer of retina

  • ventricular zone

  • habenula

  • dentate gyrus of hippocampal formation granule cell

  • lobe of cerebellum

  • cerebellar vermis

  • superior cervical ganglion

  • ureter

  • substantia nigra
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
  • RNA transmembrane transporter activity
  • protein binding
  • mRNA binding
  • nucleic acid binding
  • RNA binding
Cellular component
  • cytoplasm
  • messenger ribonucleoprotein complex
  • neuron projection
  • ribonucleoprotein granule
  • catalytic step 2 spliceosome
  • spliceosomal complex
  • nucleus
  • nucleoplasm
  • postsynaptic density
  • ribonucleoprotein complex
Biological process
  • mRNA splicing, via spliceosome
  • mRNA processing
  • mRNA transport
  • RNA splicing
  • RNA metabolic process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

220988

229279

Ensembl

ENSG00000170144

ENSMUSG00000059005

UniProt

P51991

Q8BG05

RefSeq (mRNA)
NM_001330247
NM_001330248
NM_001330249
NM_001330250
NM_001330251

NM_194247
NM_001395170

NM_053263
NM_146130
NM_198090
NM_001359971

RefSeq (protein)
NP_001317176
NP_001317177
NP_001317178
NP_001317179
NP_001317180

NP_919223

NP_444493
NP_666242
NP_932758
NP_001346900

Location (UCSC)Chr 2: 177.21 – 177.22 MbChr 2: 75.49 – 75.5 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Heterogeneous nuclear ribonucleoprotein A3 is a protein that in humans is encoded by the HNRNPA3 gene.[5][6][7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000170144 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000059005 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ma AS, Moran-Jones K, Shan J, Munro TP, Snee MJ, Hoek KS, Smith R (May 2002). "Heterogeneous nuclear ribonucleoprotein A3, a novel RNA trafficking response element-binding protein". J Biol Chem. 277 (20): 18010–20. doi:10.1074/jbc.M200050200. PMID 11886857.
  6. ^ Makeyev AV, Kim CB, Ruddle FH, Enkhmandakh B, Erdenechimeg L, Bayarsaihan D (Mar 2005). "HnRNP A3 genes and pseudogenes in the vertebrate genomes". J Exp Zool A. 303 (4): 259–71. Bibcode:2005JEZA..303..259M. doi:10.1002/jez.a.164. PMID 15776420.
  7. ^ "Entrez Gene: HNRPA3 heterogeneous nuclear ribonucleoprotein A3".

Further reading

  • Lairmore TC, Dou S, Howe JR, et al. (1993). "A 1.5-megabase yeast artificial chromosome contig from human chromosome 10q11.2 connecting three genetic loci (RET, D10S94, and D10S102) closely linked to the MEN2A locus". Proc. Natl. Acad. Sci. U.S.A. 90 (2): 492–6. Bibcode:1993PNAS...90..492L. doi:10.1073/pnas.90.2.492. PMC 45689. PMID 8093642.
  • Takiguchi S, Tokino T, Imai T, et al. (1993). "Identification and characterization of a cDNA, which is highly homologous to the ribonucleoprotein gene, from a locus (D10S102) closely linked to MEN2 (multiple endocrine neoplasia type 2)". Cytogenet. Cell Genet. 64 (2): 128–30. doi:10.1159/000133568. PMID 8101480.
  • Jurica MS, Licklider LJ, Gygi SR, et al. (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA. 8 (4): 426–39. doi:10.1017/S1355838202021088. PMC 1370266. PMID 11991638.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621.
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.


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