ITGA3 |
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Identifiers |
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Aliases | ITGA3, CD49C, GAP-B3, GAPB3, ILNEB, MSK18, VCA-2, VL3A, VLA3a, FRP-2, integrin subunit alpha 3, JEB7 |
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External IDs | OMIM: 605025; MGI: 96602; HomoloGene: 21129; GeneCards: ITGA3; OMA:ITGA3 - orthologs |
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Gene location (Human) |
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![Chromosome 17 (human)](//upload.wikimedia.org/wikipedia/commons/thumb/0/00/Ideogram_human_chromosome_17.svg/300px-Ideogram_human_chromosome_17.svg.png) | Chr. | Chromosome 17 (human)[1] |
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| Band | 17q21.33 | Start | 50,055,968 bp[1] |
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End | 50,090,481 bp[1] |
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Gene location (Mouse) |
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![Chromosome 11 (mouse)](//upload.wikimedia.org/wikipedia/commons/thumb/a/a5/Ideogram_house_mouse_chromosome_11.svg/260px-Ideogram_house_mouse_chromosome_11.svg.png) | Chr. | Chromosome 11 (mouse)[2] |
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| Band | 11 D|11 59.01 cM | Start | 94,935,300 bp[2] |
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End | 94,967,627 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - metanephric glomerulus
- right coronary artery
- upper lobe of left lung
- Descending thoracic aorta
- popliteal artery
- tibial arteries
- right lung
- right lobe of thyroid gland
- ascending aorta
- left lobe of thyroid gland
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| Top expressed in | - genital tubercle
- lumbar spinal ganglion
- decidua
- tail of embryo
- corneal stroma
- yolk sac
- crypt of lieberkuhn of small intestine
- right lung lobe
- epithelium of lens
- ileum
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| More reference expression data |
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BioGPS | ![](//upload.wikimedia.org/wikipedia/commons/thumb/0/06/PBB_GE_ITGA3_201474_s_at_fs.png/250px-PBB_GE_ITGA3_201474_s_at_fs.png) | More reference expression data |
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Gene ontology |
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Molecular function | - metal ion binding
- protein domain specific binding
- laminin binding
- collagen binding
- protease binding
- protein heterodimerization activity
- integrin binding
- fibronectin binding
- protein binding
| Cellular component | - extracellular exosome
- synapse
- integral component of membrane
- cell projection
- cell periphery
- cell junction
- growth cone
- membrane
- focal adhesion
- cell surface
- receptor complex
- synaptic membrane
- perinuclear region of cytoplasm
- excitatory synapse
- integrin complex
- basolateral plasma membrane
- filopodium membrane
- external side of plasma membrane
- integrin alpha3-beta1 complex
- plasma membrane
- growth cone filopodium
| Biological process | - positive regulation of neuron projection development
- extracellular matrix organization
- lung development
- mesodermal cell differentiation
- skin development
- maternal process involved in female pregnancy
- cell-matrix adhesion
- negative regulation of cell projection organization
- positive regulation of cell-substrate adhesion
- heart development
- dendritic spine maintenance
- positive regulation of gene expression
- nephron development
- memory
- integrin-mediated signaling pathway
- response to gonadotropin
- leukocyte migration
- renal filtration
- regulation of transforming growth factor beta receptor signaling pathway
- regulation of Wnt signaling pathway
- regulation of BMP signaling pathway
- negative regulation of Rho protein signal transduction
- exploration behavior
- positive regulation of epithelial cell migration
- neuron migration
- cell adhesion
- positive regulation of protein localization to plasma membrane
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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NM_013565 NM_001306071 NM_001306162 |
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RefSeq (protein) | | |
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NP_001293000 NP_001293091 NP_038593 |
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Location (UCSC) | Chr 17: 50.06 – 50.09 Mb | Chr 11: 94.94 – 94.97 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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