ITGA5 |
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Available structures |
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PDB | Ortholog search: PDBe RCSB |
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List of PDB id codes |
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3VI3, 3VI4, 4WJK, 4WK0, 4WK2, 4WK4 |
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Identifiers |
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Aliases | ITGA5, CD49e, FNRA, VLA5A, VLA-5, integrin subunit alpha 5 |
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External IDs | OMIM: 135620; MGI: 96604; HomoloGene: 20508; GeneCards: ITGA5; OMA:ITGA5 - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 12 (human)[1] |
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| Band | 12q13.13 | Start | 54,395,261 bp[1] |
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End | 54,419,266 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 15 (mouse)[2] |
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| Band | 15 F3|15 58.9 cM | Start | 103,252,713 bp[2] |
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End | 103,275,190 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - tibial arteries
- saphenous vein
- muscle layer of sigmoid colon
- Descending thoracic aorta
- stromal cell of endometrium
- ascending aorta
- smooth muscle tissue
- left uterine tube
- upper lobe of left lung
- right lung
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| Top expressed in | - tail of embryo
- decidua
- ascending aorta
- aortic valve
- gastrula
- stroma of bone marrow
- yolk sac
- genital tubercle
- atrium
- urinary bladder
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| More reference expression data |
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BioGPS | | More reference expression data |
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Gene ontology |
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Molecular function | - vascular endothelial growth factor receptor 2 binding
- virus receptor activity
- epidermal growth factor receptor binding
- metal ion binding
- platelet-derived growth factor receptor binding
- integrin binding
- protein binding
- cell adhesion molecule binding
| Cellular component | - cytoplasm
- integral component of membrane
- Golgi apparatus
- alphav-beta3 integrin-vitronectin complex
- membrane
- cell-cell junction
- ruffle
- plasma membrane
- synapse
- ruffle membrane
- cell surface
- integrin complex
- endoplasmic reticulum
- cytoplasmic vesicle
- external side of plasma membrane
- focal adhesion
- cell junction
| Biological process | - leukocyte cell-cell adhesion
- positive regulation of vascular endothelial growth factor receptor signaling pathway
- heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
- endodermal cell differentiation
- positive regulation of cell migration
- heterotypic cell-cell adhesion
- wound healing, spreading of epidermal cells
- extracellular matrix organization
- memory
- cell-cell adhesion mediated by integrin
- positive regulation of sprouting angiogenesis
- cell-substrate adhesion
- cell adhesion
- angiogenesis
- positive regulation of peptidyl-tyrosine phosphorylation
- cell-substrate junction assembly
- integrin-mediated signaling pathway
- viral entry into host cell
- viral process
- negative regulation of anoikis
- leukocyte migration
- positive regulation of cell-substrate adhesion
- regulation of angiogenesis
- cell adhesion mediated by integrin
- female pregnancy
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Location (UCSC) | Chr 12: 54.4 – 54.42 Mb | Chr 15: 103.25 – 103.28 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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