Integrin alpha D

Protein-coding gene in the species Homo sapiens

ITGAD
Identifiers
AliasesITGAD, ADB2, CD11D, integrin subunit alpha D
External IDsOMIM: 602453; MGI: 3578624; HomoloGene: 56919; GeneCards: ITGAD; OMA:ITGAD - orthologs
Gene location (Human)
Chromosome 16 (human)
Chr.Chromosome 16 (human)[1]
Chromosome 16 (human)
Genomic location for ITGAD
Genomic location for ITGAD
Band16p11.2Start31,393,335 bp[1]
End31,426,505 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for ITGAD
Genomic location for ITGAD
Band7|7 F3Start127,753,548 bp[2]
End127,822,988 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • granulocyte

  • spleen

  • gastrocnemius muscle

  • lymph node

  • muscle of thigh

  • appendix

  • blood

  • decidua

  • right lobe of liver

  • gallbladder
Top expressed in
  • spleen

  • spermatid

  • testicle

  • spermatocyte

  • islet of Langerhans

  • bone marrow

  • embryo

  • granulocyte

  • thymus

  • primary oocyte
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • metal ion binding
  • protein heterodimerization activity
Cellular component
  • integral component of membrane
  • cell surface
  • integrin complex
  • plasma membrane
  • membrane
Biological process
  • integrin-mediated signaling pathway
  • heterotypic cell-cell adhesion
  • extracellular matrix organization
  • cell adhesion
  • immune response
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

3681

381924

Ensembl

ENSG00000156886

ENSMUSG00000070369

UniProt

Q13349

Q3V0T4

RefSeq (mRNA)

NM_005353
NM_001318185

NM_001029872
NM_001177632

RefSeq (protein)

NP_001305114
NP_005344

NP_001025043

Location (UCSC)Chr 16: 31.39 – 31.43 MbChr 7: 127.75 – 127.82 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Integrin alpha-D is a protein that in humans is encoded by the ITGAD gene.[5][6][7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000156886 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000070369 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Wong DA, Davis EM, LeBeau M, Springer TA (Aug 1996). "Cloning and chromosomal localization of a novel gene-encoding a human beta 2-integrin alpha subunit". Gene. 171 (2): 291–4. doi:10.1016/0378-1119(95)00869-1. PMID 8666289.
  6. ^ Shelley CS, Da Silva N, Georgakis A, Chomienne C, Arnaout MA (Aug 1998). "Mapping of the human CD11c (ITGAX) and CD11d (ITGAD) genes demonstrates that they are arranged in tandem separated by no more than 11.5 kb". Genomics. 49 (2): 334–6. doi:10.1006/geno.1998.5232. PMID 9598326.
  7. ^ "Entrez Gene: ITGAD integrin, alpha D".

Further reading

  • Van der Vieren M, Le Trong H, Wood CL, et al. (1996). "A novel leukointegrin, alpha d beta 2, binds preferentially to ICAM-3". Immunity. 3 (6): 683–90. doi:10.1016/1074-7613(95)90058-6. PMID 8777714.
  • Grayson MH, Van der Vieren M, Sterbinsky SA, et al. (1999). "alphadbeta2 integrin is expressed on human eosinophils and functions as an alternative ligand for vascular cell adhesion molecule 1 (VCAM-1)". J. Exp. Med. 188 (11): 2187–91. doi:10.1084/jem.188.11.2187. PMC 2212388. PMID 9841932.
  • Van der Vieren M, Crowe DT, Hoekstra D, et al. (1999). "The leukocyte integrin alpha D beta 2 binds VCAM-1: evidence for a binding interface between I domain and VCAM-1". J. Immunol. 163 (4): 1984–90. doi:10.4049/jimmunol.163.4.1984. PMID 10438935.
  • Noti JD, Johnson AK, Dillon JD (2000). "Structural and functional characterization of the leukocyte integrin gene CD11d. Essential role of Sp1 and Sp3". J. Biol. Chem. 275 (12): 8959–69. doi:10.1074/jbc.275.12.8959. PMID 10722744.
  • Noti JD (2003). "Expression of the myeloid-specific leukocyte integrin gene CD11d during macrophage foam cell differentiation and exposure to lipoproteins". Int. J. Mol. Med. 10 (6): 721–7. doi:10.3892/ijmm.10.6.721. PMID 12429998.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Noti JD, Johnson AK, Dillon JD (2005). "The leukocyte integrin gene CD11d is repressed by gut-enriched Kruppel-like factor 4 in myeloid cells". J. Biol. Chem. 280 (5): 3449–57. doi:10.1074/jbc.M412627200. PMID 15561714.
  • ITGAD Info with links in the Cell Migration Gateway Archived 2014-12-11 at the Wayback Machine
  • v
  • t
  • e
AlphaBetaDimers
Cytoadhesin receptor:
Fibrinogen receptor:
Fibronectin receptor:
Leukocyte-adhesion receptor:
Very late antigen receptor:
Vitronectin receptor:
see also cell surface receptor deficiencies
  • v
  • t
  • e
1–50
51–100
101–150
151–200
201–250
251–300
301–350


Stub icon

This article on a gene on human chromosome 16 is a stub. You can help Wikipedia by expanding it.

  • v
  • t
  • e