KBTBD10

Protein-coding gene in the species Homo sapiens
KLHL41
Identifiers
AliasesKLHL41, KBTBD10, Krp1, NEM9, SARCOSIN, kelch like family member 41
External IDsOMIM: 607701; MGI: 2683854; HomoloGene: 4421; GeneCards: KLHL41; OMA:KLHL41 - orthologs
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for KLHL41
Genomic location for KLHL41
Band2q31.1Start169,509,702 bp[1]
End169,526,258 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for KLHL41
Genomic location for KLHL41
Band2|2 C2Start69,500,464 bp[2]
End69,514,574 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • tibialis anterior muscle

  • gastrocnemius muscle

  • muscle of thigh

  • biceps brachii

  • Skeletal muscle tissue of biceps brachii

  • Skeletal muscle tissue of rectus abdominis

  • quadriceps femoris muscle

  • body of tongue

  • vastus lateralis muscle

  • deltoid muscle
Top expressed in
  • knee joint

  • ankle

  • soleus muscle

  • muscle of thigh

  • medial head of gastrocnemius muscle

  • tibialis anterior muscle

  • skeletal muscle tissue

  • extraocular muscle

  • temporal muscle

  • sternocleidomastoid muscle
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • ubiquitin-protein transferase activity
  • protein binding
Cellular component
  • cytoplasm
  • M band
  • cell projection
  • pseudopodium
  • endoplasmic reticulum membrane
  • membrane
  • ruffle
  • Cul3-RING ubiquitin ligase complex
  • plasma membrane
  • sarcoplasmic reticulum
  • endoplasmic reticulum
  • sarcoplasmic reticulum membrane
  • cytoskeleton
  • nucleus
  • cytosol
Biological process
  • regulation of skeletal muscle cell differentiation
  • myofibril assembly
  • regulation of myoblast differentiation
  • protein ubiquitination
  • skeletal muscle cell differentiation
  • striated muscle contraction
  • regulation of myoblast proliferation
  • sarcomere organization
  • skeletal muscle fiber development
  • post-translational protein modification
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10324

228003

Ensembl

ENSG00000239474

ENSMUSG00000075307

UniProt

O60662

A2AUC9

RefSeq (mRNA)

NM_006063

NM_001081087

RefSeq (protein)

NP_006054

NP_001074556

Location (UCSC)Chr 2: 169.51 – 169.53 MbChr 2: 69.5 – 69.51 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Kelch repeat and BTB domain-containing protein 10 is a protein that in humans is encoded by the KBTBD10 gene.[5][6]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000239474 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000075307 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Taylor A, Obholz K, Linden G, Sadiev S, Klaus S, Carlson KD (Apr 1999). "DNA sequence and muscle-specific expression of human sarcosin transcripts". Mol Cell Biochem. 183 (1–2): 105–12. doi:10.1023/A:1006824331819. PMID 9655184. S2CID 22774237.
  6. ^ "Entrez Gene: KBTBD10 kelch repeat and BTB (POZ) domain containing 10".

Further reading

  • Foster LJ, Rudich A, Talior I, et al. (2006). "Insulin-dependent interactions of proteins with GLUT4 revealed through stable isotope labeling by amino acids in cell culture (SILAC)". J. Proteome Res. 5 (1): 64–75. doi:10.1021/pr0502626. PMID 16396496.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Lim DS, Roberts R, Marian AJ (2001). "Expression Profiling of Cardiac Genes in Human Hypertrophic Cardiomyopathy: Insight Into the Pathogenesis of Phenotypes". J. Am. Coll. Cardiol. 38 (4): 1175–80. doi:10.1016/S0735-1097(01)01509-1. PMC 2776821. PMID 11583900.
  • Spence HJ, Johnston I, Ewart K, et al. (2000). "Krp1, a novel kelch related protein that is involved in pseudopod elongation in transformed cells". Oncogene. 19 (10): 1266–76. doi:10.1038/sj.onc.1203433. PMID 10713668.
  • Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.


  • v
  • t
  • e