KLC1

KLC1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3NF1
Identifiers
Aliases	KLC1, KLC, KNS2, KNS2A, kinesin light chain 1
External IDs	OMIM: 600025; MGI: 107978; HomoloGene: 4056; GeneCards: KLC1; OMA:KLC1 - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q32.33 Start 103,561,896 bp[1] End 103,714,249 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12 F1|12 61.13 cM Start 111,725,283 bp[2] End 111,774,278 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum right frontal lobe C1 segment Brodmann area 9 ganglionic eminence tibial nerve anterior pituitary prefrontal cortex olfactory bulb sural nerve Top expressed in facial motor nucleus pontine nuclei dorsal tegmental nucleus medial vestibular nucleus medial dorsal nucleus habenula anterior horn of spinal cord ventral tegmental area cerebellar vermis subiculum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cytoskeletal motor activity microtubule motor activity protein binding Cellular component cell projection growth cone cytoplasmic vesicle cytoplasm microtubule cytoskeleton cytosol kinesin complex membrane Biological process microtubule-based movement antigen processing and presentation of exogenous peptide antigen via MHC class II viral process stress granule disassembly retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3831 16593 Ensembl ENSG00000126214 ENSMUSG00000021288 UniProt Q07866 O88447 RefSeq (mRNA) NM_182923 NM_001130107 NM_005552 NM_001025358 NM_001025359 NM_001025360 NM_001025361 NM_001025362 NM_001025363 NM_001081959 NM_008450 NM_001361605 NM_001361609 NM_001361610 NM_001361611 NM_001361612 NM_001361613 NM_001361614 RefSeq (protein) NP_001123579 NP_005543 NP_891553 n/a Location (UCSC) Chr 14: 103.56 – 103.71 Mb Chr 12: 111.73 – 111.77 Mb PubMed search [3] [4]
Wikidata
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Kinesin light chain 1 is a protein that in humans is encoded by the KLC1 gene.^[5][6][7]

Conventional kinesin is a tetrameric molecule composed of two heavy chains and two light chains, and transports various cargos along microtubules toward their plus ends. The heavy chains provide the motor activity, while the light chains bind to various cargos. This gene encodes a member of the kinesin light chain family. It associates with kinesin heavy chain through an N-terminal domain, and six tetratricopeptide repeat (TPR) motifs are thought to be involved in binding of cargos such as vesicles, mitochondria, and the Golgi complex. Thus, kinesin light chains function as adapter molecules and not motors per se. Although previously named "kinesin 2", this gene is not a member of the kinesin-2 / kinesin heavy chain subfamily of kinesin motor proteins. Extensive alternative splicing produces isoforms with different C-termini that are proposed to bind to different cargos; however, the full-length nature of some of these variants has not been determined.^[7]

Interactions

KLC1 has been shown to interact with MAPK8IP3,^[6] KIF5B^[8][9][10] and KIF5A.^[9][10]

References

Further reading