LAS1L

Protein-coding gene in the species Homo sapiens
LAS1L
Identifiers
AliasesLAS1L, Las1-like, dJ475B7.2, LAS1-like, ribosome biogenesis factor, LAS1 like, ribosome biogenesis factor, WTS, Las1, LAS1 like ribosome biogenesis factor, MRXSWTS
External IDsOMIM: 300964; MGI: 1923380; HomoloGene: 32746; GeneCards: LAS1L; OMA:LAS1L - orthologs
Gene location (Human)
X chromosome (human)
Chr.X chromosome (human)[1]
X chromosome (human)
Genomic location for LAS1L
Genomic location for LAS1L
BandXq12Start65,438,549 bp[1]
End65,534,810 bp[1]
Gene location (Mouse)
X chromosome (mouse)
Chr.X chromosome (mouse)[2]
X chromosome (mouse)
Genomic location for LAS1L
Genomic location for LAS1L
BandX|X C3Start94,978,941 bp[2]
End95,000,568 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right hemisphere of cerebellum

  • right frontal lobe

  • C1 segment

  • sural nerve

  • right testis

  • left testis

  • putamen

  • cingulate gyrus

  • amygdala

  • nucleus accumbens
Top expressed in
  • neural layer of retina

  • primitive streak

  • epiblast

  • muscle of thigh

  • supraoptic nucleus

  • yolk sac

  • tail of embryo

  • superior frontal gyrus

  • vas deferens

  • transitional epithelium of urinary bladder
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • RNA binding
  • endonuclease activity
Cellular component
  • MLL1 complex
  • nucleolus
  • membrane
  • nucleus
  • nucleoplasm
  • cytoplasm
  • preribosome, large subunit precursor
  • Las1 complex
Biological process
  • rRNA processing
  • maturation of 5.8S rRNA
  • maturation of LSU-rRNA
  • endonucleolytic cleavage involved in rRNA processing
  • chromatin organization
  • nucleic acid phosphodiester bond hydrolysis
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

81887

76130

Ensembl

ENSG00000001497

ENSMUSG00000057421

UniProt

Q9Y4W2

A2BE28

RefSeq (mRNA)
NM_001170649
NM_001170650
NM_031206
NM_001375328
NM_001375329

NM_001375330
NM_001375331
NM_001375332
NM_001375333
NM_001375334
NM_001375335
NM_001375336
NM_001375337

NM_152822
NM_001374717

RefSeq (protein)
NP_001164120
NP_001164121
NP_112483
NP_001362257
NP_001362258

NP_001362259
NP_001362260
NP_001362261
NP_001362262
NP_001362263
NP_001362264
NP_001362265
NP_001362266

NP_690035
NP_001361646

Location (UCSC)Chr X: 65.44 – 65.53 MbChr X: 94.98 – 95 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

LAS1-like protein is a protein that in humans is encoded by the LAS1L gene.[5][6]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000001497 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000057421 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA (Dec 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc Natl Acad Sci U S A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  6. ^ "Entrez Gene: LAS1L LAS1-like (S. cerevisiae)".

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Scherl A, Couté Y, Déon C, et al. (2003). "Functional proteomic analysis of human nucleolus". Mol. Biol. Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
  • Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. Bibcode:2005Natur.434..325R. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
  • Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.


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