Protein-coding gene in the species Homo sapiens
MAB21L2 |
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Identifiers |
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Aliases | MAB21L2, MCOPS14, Mab-21-like 2 (C. elegans), mab-21 like 2, MCSKS14 |
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External IDs | OMIM: 604357; MGI: 1346022; HomoloGene: 7824; GeneCards: MAB21L2; OMA:MAB21L2 - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 4 (human)[1] |
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| Band | 4q31.3 | Start | 150,582,151 bp[1] |
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End | 150,584,693 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 3 (mouse)[2] |
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| Band | 3|3 F1 | Start | 86,452,888 bp[2] |
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End | 86,455,936 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - muscle layer of sigmoid colon
- pons
- retinal pigment epithelium
- dorsal motor nucleus of vagus nerve
- synovial joint
- superior vestibular nucleus
- transverse colon
- Achilles tendon
- cecum
- optic nerve
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| Top expressed in | - maxillary prominence
- mandibular prominence
- abdominal wall
- superior cervical ganglion
- hand
- lens
- medial vestibular nucleus
- neural layer of retina
- iris
- embryonic cell
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| More reference expression data |
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BioGPS | |
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Gene ontology |
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Molecular function | | Cellular component | | Biological process | - eye development
- multicellular organism development
- camera-type eye development
- nervous system development
- positive regulation of cell population proliferation
- embryonic body morphogenesis
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Location (UCSC) | Chr 4: 150.58 – 150.58 Mb | Chr 3: 86.45 – 86.46 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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Mab-21-like 2 (C. elegans) is a protein that in humans is encoded by the MAB21L2 gene.[5]
Function
This gene is similar to the C. elegans MAB-21 cell fate-determining gene, a downstream target of transforming growth factor-beta signaling. It is thought that this gene may be involved in neural development. The protein encoded by this gene is primarily nuclear, although some cytoplasmic localization has been observed. [provided by RefSeq, Jul 2008].
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000181541 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000057777 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: Mab-21-like 2 (C. elegans)".
Further reading
- Mariani M, Baldessari D, Francisconi S, Viggiano L, Rocchi M, Zappavigna V, Malgaretti N, Consalez GG (December 1999). "Two murine and human homologs of mab-21, a cell fate determination gene involved in Caenorhabditis elegans neural development". Human Molecular Genetics. 8 (13): 2397–406. doi:10.1093/hmg/8.13.2397. PMID 10556287.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.