MCT-1

Protein-coding gene in humans
MCTS1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

3R90

Identifiers
AliasesMCTS1, MCT-1, MCT1, malignant T-cell amplified sequence 1, re-initiation and release factor, MCTS1 re-initiation and release factor
External IDsOMIM: 300587; MGI: 1916245; HomoloGene: 5803; GeneCards: MCTS1; OMA:MCTS1 - orthologs
Gene location (Human)
X chromosome (human)
Chr.X chromosome (human)[1]
X chromosome (human)
Genomic location for MCTS1
Genomic location for MCTS1
BandXq24Start120,594,010 bp[1]
End120,621,159 bp[1]
Gene location (Mouse)
X chromosome (mouse)
Chr.X chromosome (mouse)[2]
X chromosome (mouse)
Genomic location for MCTS1
Genomic location for MCTS1
BandX|X A3.3Start37,689,455 bp[2]
End37,702,303 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • mucosa of transverse colon

  • islet of Langerhans

  • body of pancreas

  • prefrontal cortex

  • ganglionic eminence

  • stromal cell of endometrium

  • pituitary gland

  • anterior pituitary

  • tonsil

  • right adrenal gland
Top expressed in
  • facial motor nucleus

  • barrel cortex

  • superior cervical ganglion

  • anterior horn of spinal cord

  • medial ganglionic eminence

  • sternocleidomastoid muscle

  • soleus muscle

  • dermis

  • endothelial cell of lymphatic vessel

  • triceps brachii muscle
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • translation initiation factor activity
  • RNA binding
  • protein binding
Cellular component
  • plasma membrane
  • cytosolic small ribosomal subunit
  • cytoplasm
  • cytosol
Biological process
  • translational initiation
  • cell cycle
  • regulation of growth
  • regulation of transcription, DNA-templated
  • ribosome disassembly
  • protein biosynthesis
  • formation of translation preinitiation complex
  • transcription, DNA-templated
  • positive regulation of cell population proliferation
  • cellular response to DNA damage stimulus
  • translation reinitiation
  • IRES-dependent viral translational initiation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

28985

68995

Ensembl

ENSG00000232119
ENSG00000288295

ENSMUSG00000000355

UniProt

Q9ULC4

Q9DB27

RefSeq (mRNA)

NM_001137554
NM_014060

NM_026902
NM_001356359
NM_001356360
NM_001361381
NM_001361382

RefSeq (protein)

NP_001131026
NP_054779

NP_081178
NP_001343288
NP_001343289
NP_001348310
NP_001348311

Location (UCSC)Chr X: 120.59 – 120.62 MbChr X: 37.69 – 37.7 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

MCTS1, re-initiation and release factor, otherwise known as MCT-1, is a protein that in humans is encoded by the MCTS1 gene. [5]

See also

References

  1. ^ a b c ENSG00000288295 GRCh38: Ensembl release 89: ENSG00000232119, ENSG00000288295 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000000355 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: MCTS1, re-initiation and release factor". Retrieved 2018-01-01.

Further reading

  • Shi B, Hsu HL, Evens AM, Gordon LI, Gartenhaus RB (2003). "Expression of the candidate MCT-1 oncogene in B- and T-cell lymphoid malignancies". Blood. 102 (1): 297–302. doi:10.1182/blood-2002-11-3486. PMID 12637315.
  • Shi B, Levenson V, Gartenhaus RB (2003). "Identification and characterization of a novel enhancer for the human MCT-1 oncogene promoter". J. Cell. Biochem. 90 (1): 68–79. doi:10.1002/jcb.10609. PMID 12938157. S2CID 31678534.
  • Mazan-Mamczarz K, Hagner P, Dai B, Corl S, Liu Z, Gartenhaus RB (2009). "Targeted suppression of MCT-1 attenuates the malignant phenotype through a translational mechanism". Leuk. Res. 33 (3): 474–82. doi:10.1016/j.leukres.2008.08.012. PMID 18824261.
  • Kasiappan R, Shih HJ, Chu KL, Chen WT, Liu HP, Huang SF, Choy CO, Shu CL, Din R, Chu JS, Hsu HL (2009). "Loss of p53 and MCT-1 overexpression synergistically promote chromosome instability and tumorigenicity". Mol. Cancer Res. 7 (4): 536–48. doi:10.1158/1541-7786.MCR-08-0422. PMID 19372582.
  • Pérez-Arellano I, Gozalbo-Rovira R, Martínez AI, Cervera J (2010). "Expression and purification of recombinant human MCT-1 oncogene in insect cells". Protein J. 29 (2): 69–74. doi:10.1007/s10930-009-9223-y. PMID 20076993. S2CID 5299658.
  • Chen H, Wang L, Beretov J, Hao J, Xiao W, Li Y (2010). "Co-expression of CD147/EMMPRIN with monocarboxylate transporters and multiple drug resistance proteins is associated with epithelial ovarian cancer progression". Clin. Exp. Metastasis. 27 (8): 557–69. doi:10.1007/s10585-010-9345-9. PMID 20658178. S2CID 26525740.
  • Narumi K, Furugen A, Kobayashi M, Otake S, Itagaki S, Iseki K (2010). "Regulation of monocarboxylate transporter 1 in skeletal muscle cells by intracellular signaling pathways". Biol. Pharm. Bull. 33 (9): 1568–73. doi:10.1248/bpb.33.1568. PMID 20823576.
  • Kasiappan R, Shih HJ, Wu MH, Choy C, Lin TD, Chen L, Hsu HL (2010). "The antagonism between MCT-1 and p53 affects the tumorigenic outcomes". Mol. Cancer. 9: 311. doi:10.1186/1476-4598-9-311. PMC 3019166. PMID 21138557.
  • Shih HJ, Chu KL, Wu MH, Wu PH, Chang WW, Chu JS, Wang LH, Takeuchi H, Ouchi T, Hsu HL (2012). "The involvement of MCT-1 oncoprotein in inducing mitotic catastrophe and nuclear abnormalities". Cell Cycle. 11 (5): 934–52. doi:10.4161/cc.11.5.19452. PMID 22336915.


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