Major facilitator superfamily domain containing 14a

Protein-coding gene in the species Homo sapiens
MFSD14A
Identifiers
AliasesMFSD14A, HIAT1, major facilitator superfamily domain containing 14A
External IDsMGI: 1201609; HomoloGene: 22456; GeneCards: MFSD14A; OMA:MFSD14A - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for MFSD14A
Genomic location for MFSD14A
Band1p21.2Start100,038,095 bp[1]
End100,083,377 bp[1]
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)[2]
Chromosome 3 (mouse)
Genomic location for MFSD14A
Genomic location for MFSD14A
Band3|3 G1Start116,424,813 bp[2]
End116,456,326 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • smooth muscle tissue

  • islet of Langerhans

  • endometrium

  • corpus callosum

  • monocyte

  • tibial arteries

  • gonad

  • right lung

  • placenta

  • C1 segment
Top expressed in
  • spermatocyte

  • spermatid

  • genital tubercle

  • parotid gland

  • seminal vesicula

  • Epithelium of choroid plexus

  • granulocyte

  • lacrimal gland

  • tail of embryo

  • retinal pigment epithelium
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • transporter activity
Cellular component
  • membrane
  • integral component of membrane
Biological process
  • transmembrane transport
  • acrosome assembly
  • spermatogenesis
  • spermatid development
  • spermatid nucleus differentiation
  • sperm mitochondrion organization
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

64645

15247

Ensembl

ENSG00000156875

ENSMUSG00000089911

UniProt

Q96MC6

P70187

RefSeq (mRNA)

NM_033055

NM_008246

RefSeq (protein)

NP_149044

NP_032272

Location (UCSC)Chr 1: 100.04 – 100.08 MbChr 3: 116.42 – 116.46 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Major facilitator superfamily domain containing 14A (MFSD14A, HIAT1) is a protein that in humans is encoded by the MFSD14A gene.[5][6] MFSD14A is an atypical solute carrier of MFS type.[7] HGNC:23363

MFSD14A cluster to AMTF1, together with MFSD9, MFSD10 and MFSD14B.[8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000156875 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000089911 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Major facilitator superfamily domain containing 14A".
  6. ^ Lekholm E, Perland E, Eriksson MM, Hellsten SV, Lindberg FA, Rostami J, Fredriksson R (2017-01-01). "Putative Membrane-Bound Transporters MFSD14A and MFSD14B Are Neuronal and Affected by Nutrient Availability". Frontiers in Molecular Neuroscience. 10: 11. doi:10.3389/fnmol.2017.00011. PMC 5263138. PMID 28179877.
  7. ^ Perland E, Fredriksson R (March 2017). "Classification Systems of Secondary Active Transporters". Trends in Pharmacological Sciences. 38 (3): 305–315. doi:10.1016/j.tips.2016.11.008. PMID 27939446.
  8. ^ Perland E, Bagchi S, Klaesson A, Fredriksson R (September 2017). "Characteristics of 29 novel atypical solute carriers of major facilitator superfamily type: evolutionary conservation, predicted structure and neuronal co-expression". Open Biology. 7 (9): 170142. doi:10.1098/rsob.170142. PMC 5627054. PMID 28878041.
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