NS-398
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Preferred IUPAC name N-[2-(Cyclohexyloxy)-4-nitrophenyl]methanesulfonamide | |
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Properties | |
Chemical formula | C13H18N2O5S |
Molar mass | 314.36 g·mol−1 |
Appearance | Off-white solid |
Solubility in water | Insoluble |
Solubility in DMSO | 5 mg/mL |
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Hazard statements | H302, H312, H332 |
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Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N verify (what is YN ?) Infobox references |
Chemical compound
NS-398 is a COX-2 inhibitor used in the study of the function of cyclooxygenases.[2]
See also
- Celecoxib
- Tilmacoxib (JTE-522)
References
- ^ "N194 NS-398". Sigma-Aldrich. Retrieved 13 December 2021.
- ^ Wei Shen; Yong Li; Ying Tang; James Cummins; Johnny Huard (2005). "NS-398, a Cyclooxygenase-2-Specific Inhibitor, Delays Skeletal Muscle Healing by Decreasing Regeneration and Promoting Fibrosis". American Journal of Pathology. 167 (4): 1105–1117. doi:10.1016/S0002-9440(10)61199-6. PMC 1603662. PMID 16192645.
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(ligands)
DP (D2)Tooltip Prostaglandin D2 receptor |
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EP (E2)Tooltip Prostaglandin E2 receptor |
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FP (F2α)Tooltip Prostaglandin F receptor |
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IP (I2)Tooltip Prostacyclin receptor |
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TP (TXA2)Tooltip Thromboxane receptor |
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Unsorted |
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(inhibitors)
- Precursors: Linoleic acid
- γ-Linolenic acid (gamolenic acid)
- Dihomo-γ-linolenic acid
- Diacylglycerol
- Arachidonic acid
- Prostaglandin G2
- Prostaglandin H2
- See also
- Receptor/signaling modulators
- Leukotriene signaling modulators
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