NUPL1

Protein-coding gene in the species Homo sapiens
NUP58
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

4JO7, 4JO9, 4JQ5, 5IJN, 5IJO

Identifiers
AliasesNUP58, PRO2463, NUPL1, NUP45, nucleoporin 58kDa, nucleoporin 58
External IDsOMIM: 607615; MGI: 1919094; HomoloGene: 40924; GeneCards: NUP58; OMA:NUP58 - orthologs
Gene location (Human)
Chromosome 13 (human)
Chr.Chromosome 13 (human)[1]
Chromosome 13 (human)
Genomic location for NUP58
Genomic location for NUP58
Band13q12.13Start25,301,152 bp[1]
End25,365,390 bp[1]
Gene location (Mouse)
Chromosome 14 (mouse)
Chr.Chromosome 14 (mouse)[2]
Chromosome 14 (mouse)
Genomic location for NUP58
Genomic location for NUP58
Band14|14 D1Start60,442,731 bp[2]
End60,488,956 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • gonad

  • Achilles tendon

  • right testis

  • testicle

  • left testis

  • ganglionic eminence

  • ventricular zone

  • monocyte

  • anterior pituitary

  • cartilage tissue
Top expressed in
  • cumulus cell

  • condyle

  • primitive streak

  • hair follicle

  • conjunctival fornix

  • fossa

  • Gonadal ridge

  • ureter

  • trigeminal ganglion

  • Paneth cell
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
  • nuclear localization sequence binding
  • structural constituent of nuclear pore
Cellular component
  • nuclear membrane
  • nuclear envelope
  • membrane
  • nucleus
  • nuclear pore
  • protein-containing complex
  • host cell
Biological process
  • mRNA transport
  • protein heterotetramerization
  • protein heterooligomerization
  • nucleocytoplasmic transport
  • regulation of protein import into nucleus
  • protein transport
  • viral process
  • protein homooligomerization
  • mRNA export from nucleus
  • protein import into nucleus
  • protein heterotrimerization
  • regulation of glycolytic process
  • tRNA export from nucleus
  • protein sumoylation
  • viral transcription
  • regulation of gene silencing by miRNA
  • intracellular transport of virus
  • regulation of cellular response to heat
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

9818

71844

Ensembl

ENSG00000139496

ENSMUSG00000114797

UniProt

Q9BVL2

Q8R332

RefSeq (mRNA)

NM_001008564
NM_001008565
NM_014089
NM_014778

NM_170591
NM_001362439
NM_001362440

RefSeq (protein)

NP_001008564
NP_054808

NP_733479
NP_001349368
NP_001349369

Location (UCSC)Chr 13: 25.3 – 25.37 MbChr 14: 60.44 – 60.49 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Nucleoporin p58/p45 is a protein that in humans is encoded by the NUPL1 gene.[5][6]

This gene encodes a member of the nucleoporin family that shares 87% sequence identity with rat nucleoporin p58. The protein is localized to the nuclear rim and is a component of the nuclear pore complex (NPC).

All molecules entering or leaving the nucleus either diffuse through or are actively transported by the NPC. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000139496 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000114797 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ishikawa K, Nagase T, Nakajima D, Seki N, Ohira M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Feb 1998). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 4 (5): 307–13. doi:10.1093/dnares/4.5.307. PMID 9455477.
  6. ^ a b "Entrez Gene: NUPL1 nucleoporin like 1".

Further reading

  • Buss F, Stewart M (1995). "Macromolecular interactions in the nucleoporin p62 complex of rat nuclear pores: binding of nucleoporin p54 to the rod domain of p62". J. Cell Biol. 128 (3): 251–61. doi:10.1083/jcb.128.3.251. PMC 2120351. PMID 7531196.
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Ben-Efraim I, Gerace L (2001). "Gradient of Increasing Affinity of Importin β for Nucleoporins along the Pathway of Nuclear Import". J. Cell Biol. 152 (2): 411–7. doi:10.1083/jcb.152.2.411. PMC 2199621. PMID 11266456.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
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  • 2osz: Structure of Nup58/45 suggests flexible nuclear pore diameter by intermolecular sliding
    2osz: Structure of Nup58/45 suggests flexible nuclear pore diameter by intermolecular sliding


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