PASD1

Protein-coding gene in the species Homo sapiens

PASD1
Identifiers
AliasesPASD1, CT63, OXTES1, PAS domain containing 1, PAS domain containing repressor 1, CT64
External IDsOMIM: 300993; HomoloGene: 131196; GeneCards: PASD1; OMA:PASD1 - orthologs
Gene location (Human)
X chromosome (human)
Chr.X chromosome (human)[1]
X chromosome (human)
Genomic location for PASD1
Genomic location for PASD1
BandXq28Start151,563,675 bp[1]
End151,676,739 bp[1]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • testicle

  • right testis

  • left testis

  • gonad

  • human musculoskeletal system

  • muscular system

  • muscle

  • skeletal muscle

  • muscle of lower limb

  • muscle of leg
    n/a
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • transcription coactivator binding
Cellular component
  • Cry-Per complex
  • nucleus
  • nuclear speck
Biological process
  • negative regulation of circadian rhythm
  • negative regulation of transcription, DNA-templated
  • rhythmic process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

139135

n/a

Ensembl

ENSG00000166049

n/a

UniProt

Q8IV76

n/a

RefSeq (mRNA)

NM_173493

n/a

RefSeq (protein)

NP_775764

n/a

Location (UCSC)Chr X: 151.56 – 151.68 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

PAS domain-containing protein 1 is a protein that in humans is encoded by the PASD1 gene.[3][4][5]

PASD1 has been shown to inhibit the transcriptional activity between CLOCK and BMAL1 which appears to be co-opted in cancer cells to attenuate clock function.[6][7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000166049 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Liggins AP, Guinn BA, Hatton CS, Pulford K, Banham AH (July 2004). "Serologic detection of diffuse large B-cell lymphoma-associated antigens". International Journal of Cancer. 110 (4): 563–569. doi:10.1002/ijc.20170. PMID 15122589.
  4. ^ Liggins AP, Brown PJ, Asker K, Pulford K, Banham AH (July 2004). "A novel diffuse large B-cell lymphoma-associated cancer testis antigen encoding a PAS domain protein". British Journal of Cancer. 91 (1): 141–149. doi:10.1038/sj.bjc.6601875. PMC 2364759. PMID 15162151.
  5. ^ "Entrez Gene: PASD1 PAS domain containing 1".
  6. ^ Michael AK, Harvey SL, Sammons PJ, Anderson AP, Kopalle HM, Banham AH, Partch CL (June 2015). "Cancer/Testis Antigen PASD1 Silences the Circadian Clock". Molecular Cell. 58 (5): 743–754. doi:10.1016/j.molcel.2015.03.031. PMC 4458219. PMID 25936801.
  7. ^ Greenwood V (15 September 2015). "How the Body's Trillions of Clocks Keep Time". Quanta Magazine.

Further reading

  • Hartley JL, Temple GF, Brasch MA (November 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–1795. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
  • Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (September 2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports. 1 (3): 287–292. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
  • Guinn BA, Bland EA, Lodi U, Liggins AP, Tobal K, Petters S, et al. (October 2005). "Humoral detection of leukaemia-associated antigens in presentation acute myeloid leukaemia". Biochemical and Biophysical Research Communications. 335 (4): 1293–1304. doi:10.1016/j.bbrc.2005.08.024. PMID 16112646.
  • Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, et al. (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.


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