PCLKC

Protein-coding gene in the species Homo sapiens
CDHR2
Identifiers
AliasesCDHR2, PCDH24, PCLKC, cadherin related family member 2, PCLCK
External IDsMGI: 2687323; HomoloGene: 134510; GeneCards: CDHR2; OMA:CDHR2 - orthologs
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for CDHR2
Genomic location for CDHR2
Band5q35.2Start176,542,511 bp[1]
End176,595,974 bp[1]
Gene location (Mouse)
Chromosome 13 (mouse)
Chr.Chromosome 13 (mouse)[2]
Chromosome 13 (mouse)
Genomic location for CDHR2
Genomic location for CDHR2
Band13|13 B1Start54,849,274 bp[2]
End54,884,475 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • jejunal mucosa

  • mucosa of ileum

  • duodenum

  • mucosa of transverse colon

  • rectum

  • left testis

  • right lobe of liver

  • sperm

  • right testis

  • mucosa of sigmoid colon
Top expressed in
  • jejunum

  • ileum

  • duodenum

  • epithelium of small intestine

  • colon

  • left colon

  • Paneth cell

  • yolk sac

  • right kidney

  • human kidney
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • calcium ion binding
  • protein binding
  • cell adhesion molecule binding
Cellular component
  • integral component of membrane
  • spanning component of plasma membrane
  • brush border membrane
  • cell junction
  • plasma membrane
  • extracellular exosome
  • apical plasma membrane
  • brush border
  • membrane
  • cell projection
  • microvillus membrane
Biological process
  • cell adhesion
  • epithelial cell differentiation
  • regulation of microvillus length
  • negative regulation of cell growth involved in contact inhibition
  • homophilic cell adhesion via plasma membrane adhesion molecules
  • cell-cell adhesion mediated by cadherin
  • intermicrovillar adhesion
  • cell differentiation
  • cell-cell adhesion
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

54825

268663

Ensembl

ENSG00000074276

ENSMUSG00000034918

UniProt

Q9BYE9

E9Q7P9

RefSeq (mRNA)

NM_001171976
NM_017675

NM_001033364

RefSeq (protein)

NP_001165447
NP_060145

NP_001028536

Location (UCSC)Chr 5: 176.54 – 176.6 MbChr 13: 54.85 – 54.88 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protocadherin-24 is a protein that in humans is encoded by the PCDH24 gene.[5][6][7]

Interactions

PCLKC has been shown to interact with MAST2.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000074276 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034918 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Suzuki ST (Dec 2000). "Recent progress in protocadherin research". Exp Cell Res. 261 (1): 13–8. doi:10.1006/excr.2000.5039. PMID 11082270.
  6. ^ a b Okazaki N, Takahashi N, Kojima S, Masuho Y, Koga H (Jul 2002). "Protocadherin LKC, a new candidate for a tumor suppressor of colon and liver cancers, its association with contact inhibition of cell proliferation". Carcinogenesis. 23 (7): 1139–48. doi:10.1093/carcin/23.7.1139. PMID 12117771.
  7. ^ "Entrez Gene: PCLKC protocadherin LKC".

Further reading

  • Yang LY, Wang W, Peng JX, et al. (2005). "Differentially expressed genes between solitary large hepatocellular carcinoma and nodular hepatocellular carcinoma". World J. Gastroenterol. 10 (24): 3569–73. doi:10.3748/wjg.v10.i24.3569. PMC 4611994. PMID 15534908.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.


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