PSENEN |
---|
|
Available structures |
---|
PDB | Ortholog search: PDBe RCSB |
---|
List of PDB id codes |
---|
5A63, 5FN3, 5FN4, 5FN5, 5FN2 |
|
|
Identifiers |
---|
Aliases | PSENEN, MSTP064, PEN-2, PEN2, MDS033, presenilin enhancer gamma-secretase subunit, ACNINV2, presenilin enhancer, gamma-secretase subunit |
---|
External IDs | OMIM: 607632; MGI: 1913590; HomoloGene: 11952; GeneCards: PSENEN; OMA:PSENEN - orthologs |
---|
Gene location (Human) |
---|
| Chr. | Chromosome 19 (human)[1] |
---|
| Band | 19q13.12 | Start | 35,745,600 bp[1] |
---|
End | 35,747,519 bp[1] |
---|
|
Gene location (Mouse) |
---|
| Chr. | Chromosome 7 (mouse)[2] |
---|
| Band | 7|7 B1 | Start | 30,261,288 bp[2] |
---|
End | 30,263,052 bp[2] |
---|
|
RNA expression pattern |
---|
Bgee | Human | Mouse (ortholog) |
---|
Top expressed in | - right uterine tube
- olfactory zone of nasal mucosa
- right testis
- left testis
- granulocyte
- mucosa of transverse colon
- C1 segment
- blood
- hypothalamus
- apex of heart
|
| Top expressed in | - primary oocyte
- secondary oocyte
- zygote
- thymus
- urinary bladder
- adrenal gland
- white adipose tissue
- granulocyte
- islet of Langerhans
- spleen
|
| More reference expression data |
|
---|
BioGPS | |
---|
|
Gene ontology |
---|
Molecular function | | Cellular component | - Golgi apparatus
- endoplasmic reticulum membrane
- membrane
- integral component of plasma membrane
- Golgi cisterna membrane
- endoplasmic reticulum
- integral component of membrane
- plasma membrane
- gamma-secretase complex
- endosome membrane
- mitochondrion
- integral component of presynaptic membrane
| Biological process | - Notch signaling pathway
- protein processing
- positive regulation of catalytic activity
- membrane protein ectodomain proteolysis
- Notch receptor processing
- amyloid precursor protein catabolic process
- amyloid-beta formation
- amyloid precursor protein metabolic process
- Notch receptor processing, ligand-dependent
- membrane protein intracellular domain proteolysis
- positive regulation of apoptotic process
- ephrin receptor signaling pathway
| Sources:Amigo / QuickGO |
|
Orthologs |
---|
Species | Human | Mouse |
---|
Entrez | | |
---|
Ensembl | | |
---|
UniProt | | |
---|
RefSeq (mRNA) | |
---|
NM_172341 NM_001281532 NM_018468 |
| |
---|
NM_025498 NM_001364016 NM_001364017 |
|
---|
RefSeq (protein) | | |
---|
NP_079774 NP_001350945 NP_001350946 |
|
---|
Location (UCSC) | Chr 19: 35.75 – 35.75 Mb | Chr 7: 30.26 – 30.26 Mb |
---|
PubMed search | [3] | [4] |
---|
|
Wikidata |
View/Edit Human | View/Edit Mouse |
|