PHLDA1

Protein-coding gene in the species Homo sapiens
PHLDA1
Identifiers
AliasesPHLDA1, DT1P1B11, PHRIP, TDAG51, pleckstrin homology like domain family A member 1
External IDsOMIM: 605335; MGI: 1096880; HomoloGene: 7203; GeneCards: PHLDA1; OMA:PHLDA1 - orthologs
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for PHLDA1
Genomic location for PHLDA1
Band12q21.2Start76,025,447 bp[1]
End76,031,776 bp[1]
Gene location (Mouse)
Chromosome 10 (mouse)
Chr.Chromosome 10 (mouse)[2]
Chromosome 10 (mouse)
Genomic location for PHLDA1
Genomic location for PHLDA1
Band10|10 D1Start111,342,147 bp[2]
End111,344,506 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • ventricular zone

  • stromal cell of endometrium

  • ganglionic eminence

  • salivary gland

  • minor salivary glands

  • gallbladder

  • vagina

  • right lung

  • tibial nerve

  • upper lobe of left lung
Top expressed in
  • parotid gland

  • submandibular gland

  • lacrimal gland

  • left lobe of liver

  • otic placode

  • lactiferous gland

  • crypt of lieberkuhn of small intestine

  • epithelium of stomach

  • granulocyte

  • stria vascularis
More reference expression data
BioGPS




More reference expression data
Gene ontology
Molecular function
  • protein binding
Cellular component
  • cytoplasm
  • cytoplasmic vesicle
  • cytosol
  • nucleus
  • nucleolus
Biological process
  • apoptotic process
  • FasL biosynthetic process
  • G2/M transition of mitotic cell cycle
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

22822

21664

Ensembl

ENSG00000139289

ENSMUSG00000020205

UniProt

Q8WV24

Q62392

RefSeq (mRNA)

NM_007350

NM_009344

RefSeq (protein)

NP_031376

NP_033370

Location (UCSC)Chr 12: 76.03 – 76.03 MbChr 10: 111.34 – 111.34 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Pleckstrin homology-like domain family A member 1 (PHLDA1) is a protein that in humans is encoded by the PHLDA1 gene.[5][6][7]

This gene encodes an evolutionarily conserved proline-histidine rich nuclear protein. The encoded protein may play an important role in the anti-apoptotic effects of insulin-like growth factor-1.[7]

Interactions

PHLDA1 has been shown to interact with RPL14,[8] EIF3D[8] and PABPC4.[8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000139289 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020205 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Neef R, Kuske MA, Prols E, Johnson JP (Oct 2002). "Identification of the human PHLDA1/TDAG51 gene: down-regulation in metastatic melanoma contributes to apoptosis resistance and growth deregulation". Cancer Res. 62 (20): 5920–9. PMID 12384558.
  6. ^ Toyoshima Y; Karas M; Yakar S; Dupont J; Lee Helman; LeRoith D (Jun 2004). "TDAG51 mediates the effects of insulin-like growth factor I (IGF-I) on cell survival". J Biol Chem. 279 (24): 25898–904. doi:10.1074/jbc.M400661200. PMID 15037619.
  7. ^ a b "Entrez Gene: PHLDA1 pleckstrin homology-like domain, family A, member 1".
  8. ^ a b c Hinz, T; Flindt S; Marx A; Janssen O; Kabelitz D (May 2001). "Inhibition of protein synthesis by the T cell receptor-inducible human TDAG51 gene product". Cell. Signal. 13 (5). England: 345–52. doi:10.1016/S0898-6568(01)00141-3. ISSN 0898-6568. PMID 11369516.

Further reading

  • Reddy PH, Stockburger E, Gillevet P, Tagle DA (1998). "Mapping and characterization of novel (CAG)n repeat cDNAs from adult human brain derived by the oligo capture method". Genomics. 46 (2): 174–82. doi:10.1006/geno.1997.5044. PMID 9417904.
  • Kuske MD, Johnson JP (2000). "Assignment of the human PHLDA1 gene to chromosome 12q15 by radiation hybrid mapping". Cytogenet. Cell Genet. 89 (1–2): 1. doi:10.1159/000015575. PMID 10894922. S2CID 84103198.
  • Hinz T, Flindt S, Marx A, et al. (2001). "Inhibition of protein synthesis by the T cell receptor-inducible human TDAG51 gene product". Cell. Signal. 13 (5): 345–52. doi:10.1016/S0898-6568(01)00141-3. PMID 11369516.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Hossain GS, van Thienen JV, Werstuck GH, et al. (2003). "TDAG51 Is Induced by Homocysteine, Promotes Detachment-mediated Programmed Cell Death, and Contributes to the Development of Atherosclerosis in Hyperhomocysteinemia". J. Biol. Chem. 278 (32): 30317–27. doi:10.1074/jbc.M212897200. PMID 12738777.
  • Oberg HH, Sipos B, Kalthoff H, et al. (2005). "Regulation of T-cell death-associated gene 51 (TDAG51) expression in human T-cells". Cell Death Differ. 11 (6): 674–84. doi:10.1038/sj.cdd.4401407. PMID 15002043.
  • Meier-Noorden M, Flindt S, Kalinke U, Hinz T (2004). "A CpG-rich bidirectional promoter induces the T-cell death-associated gene 51 and downregulates an inversely oriented transcript during early T-cell activation". Gene. 338 (2): 197–207. doi:10.1016/j.gene.2004.05.006. PMID 15315823.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.


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