PPFIA4

Protein-coding gene in the species Homo sapiens
PPFIA4
Identifiers
AliasesPPFIA4, PTPRF interacting protein alpha 4
External IDsOMIM: 603145; GeneCards: PPFIA4; OMA:PPFIA4 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for PPFIA4
Genomic location for PPFIA4
Band1q32.1Start203,026,491 bp[1]
End203,078,740 bp[1]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • cerebellar hemisphere

  • right hemisphere of cerebellum

  • cerebellar vermis

  • paraflocculus of cerebellum

  • right frontal lobe

  • primary visual cortex

  • Brodmann area 9

  • middle temporal gyrus

  • apex of heart

  • cingulate gyrus
    n/a
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
Cellular component
  • cytoplasm
  • presynaptic active zone
  • cell surface
  • cytosol
  • synapse
  • intracellular anatomical structure
Biological process
  • glutamate secretion
  • neurotransmitter secretion
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

8497

n/a

Ensembl

ENSG00000143847

n/a

UniProt

O75335

n/a

RefSeq (mRNA)
NM_001304331
NM_001304332
NM_015053
NM_001393950
NM_001393951

NM_001393952
NM_001393953
NM_001393954
NM_001393955
NM_001393956
NM_001393957

n/a

RefSeq (protein)

NP_001291260
NP_001291261

n/a

Location (UCSC)Chr 1: 203.03 – 203.08 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Liprin-alpha-4 is a protein that in humans is encoded by the PPFIA4 gene.[3][4]

Interactions

PPFIA4 has been shown to interact with:

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000143847 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Serra-Pagès C, Medley QG, Tang M, Hart A, Streuli M (Jul 1998). "Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins". J Biol Chem. 273 (25): 15611–20. doi:10.1074/jbc.273.25.15611. PMID 9624153.
  4. ^ "Entrez Gene: PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4".
  5. ^ a b Ko J, Na M, Kim S, Lee JR, Kim E (Oct 2003). "Interaction of the ERC family of RIM-binding proteins with the liprin-alpha family of multidomain proteins". J. Biol. Chem. 278 (43): 42377–85. doi:10.1074/jbc.M307561200. PMID 12923177.
  6. ^ Ko J, Kim S, Valtschanoff JG, Shin H, Lee JR, Sheng M, Premont RT, Weinberg RJ, Kim E (Mar 2003). "Interaction between liprin-alpha and GIT1 is required for AMPA receptor targeting". J. Neurosci. 23 (5): 1667–77. doi:10.1523/JNEUROSCI.23-05-01667.2003. PMC 6741975. PMID 12629171.
  7. ^ Wyszynski M, Kim E, Dunah AW, Passafaro M, Valtschanoff JG, Serra-Pagès C, Streuli M, Weinberg RJ, Sheng M (Mar 2002). "Interaction between GRIP and liprin-alpha/SYD2 is required for AMPA receptor targeting". Neuron. 34 (1): 39–52. doi:10.1016/s0896-6273(02)00640-2. PMID 11931740. S2CID 16142847.

Further reading

  • Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
  • Millar JK, Christie S, Porteous DJ (2004). "Yeast two-hybrid screens implicate DISC1 in brain development and function". Biochem. Biophys. Res. Commun. 311 (4): 1019–25. doi:10.1016/j.bbrc.2003.10.101. PMID 14623284.
  • Katoh M, Katoh M (2004). "Identification and characterization of human PPFIA4 gene in silico". Int. J. Mol. Med. 12 (6): 1009–14. doi:10.3892/ijmm.12.6.1009. PMID 14612982.
  • Ko J, Na M, Kim S, Lee JR, Kim E (2004). "Interaction of the ERC family of RIM-binding proteins with the liprin-alpha family of multidomain proteins". J. Biol. Chem. 278 (43): 42377–85. doi:10.1074/jbc.M307561200. PMID 12923177.
  • Ko J, Kim S, Valtschanoff JG, Shin H, Lee JR, Sheng M, Premont RT, Weinberg RJ, Kim E (2003). "Interaction between liprin-alpha and GIT1 is required for AMPA receptor targeting". J. Neurosci. 23 (5): 1667–77. doi:10.1523/JNEUROSCI.23-05-01667.2003. PMC 6741975. PMID 12629171.
  • Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.


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