Pappalysin-2

Protein-coding gene in the species Homo sapiens
PAPPA2
Identifiers
AliasesPAPPA2, PAPP-A2, PAPP-E, PAPPE, PLAC3, pappalysin 2, SSDA
External IDsMGI: 3051647; HomoloGene: 10661; GeneCards: PAPPA2; OMA:PAPPA2 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for PAPPA2
Genomic location for PAPPA2
Band1q25.2Start176,463,171 bp[1]
End176,845,601 bp[1]
Gene location (Mouse)
Chromosome 1 (mouse)
Chr.Chromosome 1 (mouse)[2]
Chromosome 1 (mouse)
Genomic location for PAPPA2
Genomic location for PAPPA2
Band1|1 H1Start158,539,297 bp[2]
End158,808,060 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • decidua

  • islet of Langerhans

  • cartilage tissue

  • ventricular zone

  • buccal mucosa cell

  • testicle

  • ganglionic eminence

  • human kidney

  • pancreatic ductal cell

  • stromal cell of endometrium
Top expressed in
  • calvaria

  • islet of Langerhans

  • lumbar spinal ganglion

  • pituitary gland

  • pontine nuclei

  • trigeminal ganglion

  • dermis

  • lobe of prostate

  • efferent ductule

  • condyle
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • zinc ion binding
  • peptidase activity
  • hydrolase activity
  • metallopeptidase activity
  • metal ion binding
  • metalloendopeptidase activity
Cellular component
  • extracellular region
  • extracellular exosome
  • intracellular anatomical structure
  • cytosol
  • apical plasma membrane
Biological process
  • bone morphogenesis
  • regulation of cell growth
  • proteolysis
  • response to salt stress
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

60676

23850

Ensembl

ENSG00000116183

ENSMUSG00000073530

UniProt

Q9BXP8

n/a

RefSeq (mRNA)

NM_020318
NM_021936

NM_001085376

RefSeq (protein)

NP_064714
NP_068755

n/a

Location (UCSC)Chr 1: 176.46 – 176.85 MbChr 1: 158.54 – 158.81 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Pappalysin-2 also known as pregnancy-associated plasma protein A2 (PAPP-A2) is a protein that in humans is encoded by the PAPPA2 gene.[5][6][7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000116183 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000073530 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Farr M, Strube J, Geppert HG, Kocourek A, Mahne M, Tschesche H (Nov 2000). "Pregnancy-associated plasma protein-E (PAPP-E)". Biochim Biophys Acta. 1493 (3): 356–62. doi:10.1016/s0167-4781(00)00195-0. PMID 11018262.
  6. ^ Overgaard MT, Boldt HB, Laursen LS, Sottrup-Jensen L, Conover CA, Oxvig C (Jun 2001). "Pregnancy-associated plasma protein-A2 (PAPP-A2), a novel insulin-like growth factor-binding protein-5 proteinase". J Biol Chem. 276 (24): 21849–53. doi:10.1074/jbc.M102191200. PMID 11264294.
  7. ^ "Entrez Gene: PAPPA2 pappalysin 2".

Further reading

  • Firth SM, Baxter RC (2003). "Cellular actions of the insulin-like growth factor binding proteins". Endocr. Rev. 23 (6): 824–54. doi:10.1210/er.2001-0033. PMID 12466191.
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
  • Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Page NM, Butlin DJ, Lomthaisong K, Lowry PJ (2001). "The characterization of pregnancy associated plasma protein-E and the identification of an alternative splice variant". Placenta. 22 (8–9): 681–7. doi:10.1053/plac.2001.0709. PMID 11597188.
  • Ständker L, Wobst P, Mark S, Forssmann WG (1999). "Isolation and characterization of circulating 13-kDa C-terminal fragments of human insulin-like growth factor binding protein-5". FEBS Lett. 441 (2): 281–6. doi:10.1016/S0014-5793(98)01497-5. PMID 9883900.


  • v
  • t
  • e