Phosphomolybdic acid
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Other names Molybdophosphoric acid; dodecamolybdophosphoric acid | |
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ECHA InfoCard | 100.031.544 ![]() |
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MeSH | Phosphomolybdic+acid |
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Properties | |
Chemical formula | H3[PMo12O40] |
Molar mass | 1825.25 g/mol |
Density | 1.62 g/ml[1] (hydrate) |
Melting point | 79-90 °C[1] |
Solubility in water | soluble |
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Occupational safety and health (OHS/OSH): | |
Main hazards | Oxidiser[1] (hydrate) |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). ![]() ![]() ![]() Infobox references |
Phosphomolybdic acid is the heteropolymetalate with the formula H3[Mo12PO40]·12H2O. It is a yellow solid, although even slightly impure samples have a greenish coloration. It is also known as dodeca molybdophosphoric acid or PMA, is a yellow-green chemical compound that is freely soluble in water and polar organic solvents such as ethanol. It is used as a stain in histology and in organic synthesis.[2]
Histology
Phosphomolybdic acid is a component of Masson's trichrome stain.[3]
Organic synthesis
Phosphomolybdic is used as a stain for developing thin-layer chromatography plates,[4] staining phenolics, hydrocarbon waxes, alkaloids, and steroids. Conjugated unsaturated compounds reduce PMA to molybdenum blue. The color intensifies with increasing number of double bonds in the molecule being stained.[5]
Phosphomolybdic acid is also occasionally used in acid-catalyzed reactions in organic synthesis. It has been shown to be a good catalyst for the Skraup reaction for the synthesis of substituted quinolines.[6]
Bismuth phosphomolybdate catalyzes ammoxidation in the Sohio process.[7]
See also
References
- ^ a b c "Phosphomolybdic acid hydrate - Safety data sheet" (PDF). www.sigmaaldrich.com. 2016-07-18. Retrieved 2018-10-06.
- ^ Dias, J. A.; Dias, S. C. L.; Caliman, E. (2014). "Keggin Structure Polyoxometalates". Inorganic Syntheses: Volume 36. Inorganic Syntheses. Vol. 36. p. 210-217. doi:10.1002/9781118744994.ch39. ISBN 9781118744994.
- ^ "Masson's Trichrome for Muscle and Collagen". StainsFile. Archived from the original on 2013-07-02. Retrieved 2018-10-06.
- ^ "Stains for Developing TLC Plates" (PDF). McMaster University.
- ^ Burstein, Shlomo (1953). "Reduction of Phosphomolybdic Acid by Compounds Possessing Conjugated Double Bonds". Analytical Chemistry. 25 (3): 422–424. doi:10.1021/ac60075a012. ISSN 0003-2700 – via ACS Publications.
- ^ Chaskar, Atul; Padalkar, Vikas; Phatangare, Kiran; et al. (2010). "Miceller-Mediated Phosphomolybdic Acid: Highly Effective Reusable Catalyst for Synthesis of Quinoline and Its Derivatives". Synthetic Communications. 40 (15): 2336–2340. doi:10.1080/00397910903245141. ISSN 0039-7911. S2CID 94978408 – via Taylor & Francis Online.
- ^ "Sohio Acrylonitrile process". ACS Chemical Landmarks. Washington, DC: American Chemical Society. 2007. Retrieved 1 Aug 2024.